{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T07:38:11Z","timestamp":1768549091070,"version":"3.49.0"},"posted":{"date-parts":[[2021,3,5]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":13,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>As highlighted by the ongoing COVID-19 pandemic, vaccination is critical for infectious disease prevention and control. Obesity is associated with increased morbidity and mortality from respiratory virus infections. While obese individuals respond to influenza vaccination, what is considered a seroprotective response may not fully protect the global obese population. In a cohort vaccinated with the 2010-2011 trivalent inactivated influenza vaccine, baseline immune history and vaccination responses were found to significantly differ in obese individuals compared to healthy controls, especially towards the 2009 pandemic strain of A\/H1N1 influenza virus. Young, obese individuals displayed responses skewed towards linear peptides versus conformational antigens, suggesting aberrant obese immune response. Overall, these data have vital implications for the next generation of influenza vaccines, and towards the current SARS-CoV-2 vaccination campaign.<\/jats:p>\n                <jats:sec>\n                  <jats:title>One Sentence Summary<\/jats:title>\n                  <jats:p>Obese individuals have altered baseline and post-vaccination influenza antibody repertoires.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2021.03.02.21252785","type":"posted-content","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T15:46:52Z","timestamp":1614959212000},"source":"Crossref","is-referenced-by-count":0,"title":["Obesity is associated with an altered baseline and post-vaccination influenza antibody repertoire"],"prefix":"10.64898","author":[{"given":"Marwa Abd","family":"Alhadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilach M.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6004-5671","authenticated-orcid":false,"given":"Erik A","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liel","family":"Cohen-Lavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat","family":"Burkovitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey","family":"Schultz-Cherry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry L","family":"Noah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel S","family":"Weir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester M.","family":"Shulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda A","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-1578","authenticated-orcid":false,"given":"Tomer","family":"Hertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2021030800350877000_2021.03.02.21252785v1.1","doi-asserted-by":"crossref","first-page":"S406","DOI":"10.1513\/AnnalsATS.201706-447AW","article-title":"Obesity Impairs the Adaptive Immune Response to Influenza Virus","volume":"14","year":"2017","journal-title":"Annals of the American Thoracic Society"},{"key":"2021030800350877000_2021.03.02.21252785v1.2","unstructured":"S. Seidu et al., The impact of obesity on severe disease and mortality in people with SARS-CoV-2: A systematic review and meta-analysis. Endocrinology, diabetes & metabolism, e00176 (2020)."},{"key":"2021030800350877000_2021.03.02.21252785v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2521-4"},{"key":"2021030800350877000_2021.03.02.21252785v1.4","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/ijo.2017.131","article-title":"Increased risk of influenza among vaccinated adults who are obese","volume":"41","year":"2017","journal-title":"International journal of obesity"},{"key":"2021030800350877000_2021.03.02.21252785v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.208"},{"key":"2021030800350877000_2021.03.02.21252785v1.6","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq152"},{"key":"2021030800350877000_2021.03.02.21252785v1.7","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2711-0"},{"key":"2021030800350877000_2021.03.02.21252785v1.8","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/ajcn\/59.4.810","article-title":"The predictive value of childhood body mass index values for overweight at age 35 y","volume":"59","year":"1994","journal-title":"The American journal of clinical nutrition"},{"key":"2021030800350877000_2021.03.02.21252785v1.9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.e29"},{"key":"2021030800350877000_2021.03.02.21252785v1.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709253371301"},{"key":"2021030800350877000_2021.03.02.21252785v1.11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061627"},{"key":"2021030800350877000_2021.03.02.21252785v1.12","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1002\/oby.20383","article-title":"Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus","volume":"21","year":"2013","journal-title":"Obesity"},{"key":"2021030800350877000_2021.03.02.21252785v1.13","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1038\/nprot.2014.180","article-title":"Influenza A virus isolation, culture and identification","volume":"9","year":"2014","journal-title":"Nature protocols"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2021.03.02.21252785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:09:08Z","timestamp":1768486148000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2021.03.02.21252785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":13,"URL":"https:\/\/doi.org\/10.1101\/2021.03.02.21252785","relation":{},"subject":[],"published":{"date-parts":[[2021,3,5]]},"subtype":"preprint"}}