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The worldwide scientific community is forging ahead to characterize a wide range of outcomes associated with SARS-CoV-2 infection; however the underlying assumptions in these studies have varied so widely that the resulting data are difficult to compareFormal definitions are needed in order to design robust and consistent studies of Long COVID that consistently capture variation in long-term outcomes. Even the condition itself goes by three terms, most widely \u201cLong COVID\u201d, but also \u201cCOVID-19 syndrome (PACS)\u201d or, \u201cpost-acute sequelae of SARS-CoV-2 infection (PASC)\u201d. In the present study, we investigate the definitions used in the literature published to date and compare them against data available from electronic health records and patient-reported information collected via surveys. Long COVID holds the potential to produce a second public health crisis on the heels of the pandemic itself. Proactive efforts to identify the characteristics of this heterogeneous condition are imperative for a rigorous scientific effort to investigate and mitigate this threat.<\/jats:p>","DOI":"10.1101\/2021.03.20.21253896","type":"posted-content","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T13:30:30Z","timestamp":1616765430000},"source":"Crossref","is-referenced-by-count":101,"title":["Challenges in defining Long COVID: Striking differences across literature, Electronic Health Records, and patient-reported information"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-1770","authenticated-orcid":false,"given":"Halie M.","family":"Rando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1483-4236","authenticated-orcid":false,"given":"Tellen 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