{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:11:05Z","timestamp":1768554665221,"version":"3.49.0"},"posted":{"date-parts":[[2022,4,5]]},"group-title":"Respiratory Medicine","reference-count":13,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Patients hospitalized with COVID-19 are at significant risk for superimposed bacterial pneumonia. However, diagnosing superinfection is challenging due to its clinical resemblance to severe COVID-19. We therefore evaluated whether the immune biomarker, procalcitonin, could facilitate the diagnosis of bacterial superinfection. To do so, we identified 185 patients with severe COVID-19 who underwent lower respiratory culture; 85 had superinfection. Receiver operating characteristic curve analysis showed that procalcitonin at the time of culture was incapable of distinguishing patients with bacterial infection (AUC, 0.52). We conclude that static measurement of procalcitonin does not aid in the diagnosis of superinfection in severe COVID-19.<\/jats:p>","DOI":"10.1101\/2022.03.29.22272960","type":"posted-content","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T17:35:20Z","timestamp":1649352920000},"source":"Crossref","is-referenced-by-count":0,"title":["Nonutility of procalcitonin for diagnosing bacterial pneumonia in COVID-19"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-5365","authenticated-orcid":false,"given":"Avi J.","family":"Cohen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura R.","family":"Glick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seohyuk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Kunitomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek A.","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Pitafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Valda","family":"Toro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupak","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Dela Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9443-164X","authenticated-orcid":false,"given":"Samir","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2022040714351011000_2022.03.29.22272960v1.1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1164\/rccm.202106-1354OC","article-title":"Bacterial superinfection pneumonia in patients mechanically ventilated for COVID-19 pneumonia","volume":"204","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2022040714351011000_2022.03.29.22272960v1.2","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1164\/rccm.202101-0030OC","article-title":"Early bacterial identification among intubated patients with COVID-19 or influenza pneumonia: A european multicenter comparative clinical trial","volume":"204","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2022040714351011000_2022.03.29.22272960v1.3","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ccm.2018.08.008","article-title":"Personalizing the Management of Pneumonia","volume":"39","year":"2018","journal-title":"Clin Chest Med"},{"key":"2022040714351011000_2022.03.29.22272960v1.4","doi-asserted-by":"crossref","unstructured":"May M , Chang M , Dietz D , Shoucri S , Laracy J , Sobieszczyk ME , Uhlemann AC , Zucker J , Kubin CJ . 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Bronchoscopy on intubated patients with COVID-19 is associated with low infectious risk to operators. Ann Am Thorac Soc 2021;","DOI":"10.1513\/AnnalsATS.202009-1225RL"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2022.03.29.22272960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:40:25Z","timestamp":1768488025000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2022.03.29.22272960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":13,"URL":"https:\/\/doi.org\/10.1101\/2022.03.29.22272960","relation":{},"subject":[],"published":{"date-parts":[[2022,4,5]]},"subtype":"preprint"}}