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Using RNA sequencing of FACS sorted retro-labeled sensory neurons innervating tongue tissue, we determined changes in transcriptomic profiles in males and female mice under na\u00efve as well as tongue-tumor bearing conditions Our data revealed the following interesting findings: 1) Tongue tissue of female mice was innervated with higher number of trigeminal neurons compared to males; 2) Na\u00efve female neurons innervating the tongue exclusively expressed immune cell markers such as Csf1R, C1qa and others, that weren\u2019t expressed in males. This was validated by Immunohistochemistry. 4) Accordingly, immune cell markers such as Csf1 exclusively sensitized TRPV1 responses in female TG neurons. 3) Male neurons were more tightly regulated than female neurons upon tumor growth and very few differentially expressed genes (DEGs) overlapped between the sexes, 5) Male DEGs contained higher number of transcription factors whereas female DEGs contained higher number of enzymes, cytokines and chemokines. Collectively, this is the first study to characterize the effect of sex as well as of tongue-tumor on global gene expression, pathways and molecular function of tongue-innervating sensory neurons.<\/jats:p>","DOI":"10.1101\/2023.01.14.524011","type":"posted-content","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T04:33:59Z","timestamp":1674016439000},"source":"Crossref","is-referenced-by-count":2,"title":["Sex-dependent Differences in the Genomic Profile of Lingual Sensory Neurons in Na\u00efve and Tongue-Tumor Bearing Mice"],"prefix":"10.64898","author":[{"given":"Tarek","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ju","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Fang-Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josue","family":"Murillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaclyn","family":"Merlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei","family":"Tumanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korri","family":"Weldon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Ruparel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023051800401029000_2023.01.14.524011v2.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00708.x"},{"key":"2023051800401029000_2023.01.14.524011v2.2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001872"},{"key":"2023051800401029000_2023.01.14.524011v2.3","doi-asserted-by":"crossref","first-page":"599580","DOI":"10.3389\/fnint.2021.599580","article-title":"Editorial: Mechanisms of Orofacial Pain and Sex Differences","volume":"15","year":"2021","journal-title":"Front Integr Neurosci"},{"key":"2023051800401029000_2023.01.14.524011v2.4","first-page":"1744806919900725","article-title":"Apical periodontitis-induced mechanical allodynia: A mouse model to study infection-induced chronic pain conditions","volume":"16","year":"2020","journal-title":"Mol Pain"},{"key":"2023051800401029000_2023.01.14.524011v2.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00408-5"},{"key":"2023051800401029000_2023.01.14.524011v2.6","doi-asserted-by":"crossref","unstructured":"Sessle, B. 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