{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:25:25Z","timestamp":1768505125479,"version":"3.49.0"},"posted":{"date-parts":[[2023,1,18]]},"group-title":"Neuroscience","reference-count":55,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Human cortical responses to natural sounds, measured with fMRI, can be approximated as the weighted sum of a small number of canonical response patterns (components), each having interpretable functional and anatomical properties. Here, we asked whether this organization is preserved in cases where only one temporal lobe is available due to early brain damage by investigating a unique family: one sibling born without a left temporal lobe, another without a right temporal lobe, and a third anatomically neurotypical. We analyzed fMRI responses to diverse natural sounds within the intact hemispheres of these individuals and compared them to 12 neurotypical participants. All siblings manifested the neurotypical auditory responses in their intact hemispheres. These results suggest that the development of the auditory cortex in each hemisphere does not depend on the existence of the other hemisphere, highlighting the redundancy and equipotentiality of the bilateral auditory system.<\/jats:p>","DOI":"10.1101\/2023.01.18.523979","type":"posted-content","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T03:10:12Z","timestamp":1674097812000},"source":"Crossref","is-referenced-by-count":0,"title":["Preserved functional organization of human auditory cortex in individuals missing one temporal lobe from infancy"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0639-0890","authenticated-orcid":false,"given":"Tamar I","family":"Regev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Lipkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-4360","authenticated-orcid":false,"given":"Dana","family":"Boebinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4342-0534","authenticated-orcid":false,"given":"Alexander","family":"Paunov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3684-8225","authenticated-orcid":false,"given":"Hope","family":"Kean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9342-6868","authenticated-orcid":false,"given":"Sam","family":"Norman-Haignere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3823-514X","authenticated-orcid":false,"given":"Evelina","family":"Fedorenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023012019050914000_2023.01.18.523979v1.1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq198"},{"key":"2023012019050914000_2023.01.18.523979v1.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz3468"},{"key":"2023012019050914000_2023.01.18.523979v1.3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cortex.2020.02.006","article-title":"Language development and brain reorganization in a child born without the left hemisphere","volume":"127","year":"2020","journal-title":"Cortex"},{"key":"2023012019050914000_2023.01.18.523979v1.4","first-page":"1707","article-title":"Hearing disorders in stroke, 1st ed. 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