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We describe our methodologies for SV inference resulting in high variant quality and &gt;90% allele concordance compared to long-read de-novo assemblies of well-characterized control samples. We demonstrate utility through significant associations between SVs and important various cardio-metabolic and hemotologic traits. We have identified 690 SV hotspots and deserts and those that potentially impact the regulation of medically relevant genes. This catalog characterizes SVs across multiple populations and will serve as a valuable tool to understand the impact of SV on disease development and progression.<\/jats:p>","DOI":"10.1101\/2023.01.25.525428","type":"posted-content","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T09:50:11Z","timestamp":1674726611000},"source":"Crossref","is-referenced-by-count":19,"title":["Structural variation across 138,134 samples in the TOPMed consortium"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-0204","authenticated-orcid":false,"given":"Goo","family":"Jun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2451-4375","authenticated-orcid":false,"given":"Adam C","family":"English","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8316-0071","authenticated-orcid":false,"given":"Ginger 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