{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:30:34Z","timestamp":1768505434133,"version":"3.49.0"},"posted":{"date-parts":[[2023,1,27]]},"group-title":"Bioinformatics","reference-count":13,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Large scale meta-analyses of genomics and genetics have spurred research in a number of fields, such as cancer, genetics and immunology. Publicly available \u2018omics databases provide valuable hypothesis generating and validation tools. To date, no such initiative has been undertaken for Hidradenitis Suppurativa (HS), an inflammatory skin disease of unknown etiology. We present here, a longitudinal initiative seeking to aggregate publicly available \u2018omics data to enhance research efforts in HS. In its first iteration, we include bulk and single-cell RNA sequencing data from untreated HS patients. Our data, aggregated from publicly available GEO datasets provides a tool to profile gene expression in specific tissue types (i.e. lesional, perilesional, nonlesional and healthy skin) as well as map cell-specific gene expression on single-cell data from HS lesions.<\/jats:p>","DOI":"10.1101\/2023.01.26.524600","type":"posted-content","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T20:01:01Z","timestamp":1674849661000},"source":"Crossref","is-referenced-by-count":0,"title":["The Hidradenitis Suppurativa \u2018Omics Database (HS-OmicsDB)"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-5962","authenticated-orcid":false,"given":"Peter","family":"Dimitrion","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4645-6559","authenticated-orcid":false,"given":"Ian","family":"Loveless","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1411-6827","authenticated-orcid":false,"given":"Qing-Sheng","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9973-3057","authenticated-orcid":false,"given":"Indra","family":"Adrianto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023013112500904000_2023.01.26.524600v1.1","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.3389\/fimmu.2018.02262","article-title":"Macrophage Migration Inhibitory Factor (MIF) Drives Murine Psoriasiform Dermatitis","volume":"9","year":"2018","journal-title":"Front Immunol"},{"key":"2023013112500904000_2023.01.26.524600v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0292-x"},{"key":"2023013112500904000_2023.01.26.524600v1.3","doi-asserted-by":"crossref","unstructured":"Gudjonsson JE , Tsoi LC , Ma F , Billi AC , van Straalen KR , Vossen ARJV , et al. Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis. JCI Insight 2020;5(19).","DOI":"10.1172\/jci.insight.139930"},{"key":"2023013112500904000_2023.01.26.524600v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4"},{"issue":"12","key":"2023013112500904000_2023.01.26.524600v1.5","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","year":"2019","journal-title":"Nat Methods"},{"key":"2023013112500904000_2023.01.26.524600v1.6","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKZ114"},{"key":"2023013112500904000_2023.01.26.524600v1.7","first-page":"665873","article-title":"Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa","volume":"8","year":"2021","journal-title":"Front Med (Lausanne)"},{"issue":"17","key":"2023013112500904000_2023.01.26.524600v1.8","doi-asserted-by":"crossref","first-page":"eabn4776","DOI":"10.1126\/sciadv.abn4776","article-title":"Machine learning reveals distinct gene signature profiles in lesional and nonlesional regions of inflammatory skin diseases","volume":"8","year":"2022","journal-title":"Sci Adv"},{"key":"2023013112500904000_2023.01.26.524600v1.9","doi-asserted-by":"crossref","unstructured":"Reynolds G , Vegh P , Fletcher J , Poyner EFM , Stephenson E , Goh I , et al. Developmental cell programs are co-opted in inflammatory skin disease. Science 2021;371(6527).","DOI":"10.1126\/science.aba6500"},{"issue":"1","key":"2023013112500904000_2023.01.26.524600v1.10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-020-0149-1","article-title":"Hidradenitis suppurativa","volume":"6","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"2023013112500904000_2023.01.26.524600v1.11","doi-asserted-by":"publisher","DOI":"10.1177\/1203475420972348"},{"key":"2023013112500904000_2023.01.26.524600v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"issue":"4","key":"2023013112500904000_2023.01.26.524600v1.13","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jaci.2022.02.003","article-title":"Insights into hidradenitis suppurativa","volume":"149","year":"2022","journal-title":"J Allergy Clin Immunol"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2023.01.26.524600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:12:08Z","timestamp":1768450328000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2023.01.26.524600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":13,"URL":"https:\/\/doi.org\/10.1101\/2023.01.26.524600","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1016\/j.jid.2023.05.013","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2023,1,27]]},"subtype":"preprint"}}