{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T18:37:37Z","timestamp":1768502257289,"version":"3.49.0"},"posted":{"date-parts":[[2023,1,28]]},"group-title":"Immunology","reference-count":61,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,1,28]]},"abstract":"<jats:label>2.<\/jats:label>\n                <jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hidradenitis suppurativa (HS) is a multifactorial, inflammatory skin disease. Increased systemic inflammatory comorbidities and serum cytokines highlight systemic inflammation as a feature of HS. However, the specific immune cell subsets contributing to systemic and cutaneous inflammation have not been resolved.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Identify features of peripheral and cutaneous immune dysregulation.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Here, we generated whole-blood immunomes by mass cytometry. We performed a meta-analysis of RNA-seq data, immunohistochemistry, and imaging mass cytometry to characterize the immunological landscape of skin lesions and perilesions from patients with HS.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Blood from patients with HS exhibited lower frequencies of natural killer cells, dendritic cells, and classical (CD14+CD16-) and nonclassical (CD14-CD16+) monocytes, as well as higher frequencies of Th17 cells and intermediate (CD14+CD16+) monocytes than blood from healthy controls. Classical and intermediate monocytes from patients with HS had increased expression of skin-homing chemokine receptors. Furthermore, we identified a CD38+ intermediate monocyte subpopulation that was more abundant in the immunome of blood from patients with HS. Meta-analysis of RNA-seq data found higher CD38 expression in lesional HS skin than in perilesional skin, and markers of classical monocyte infiltration. Imaging mass cytometry showed that CD38+ classical monocytes and CD38+ monocyte-derived macrophages were more abundant in lesional HS skin.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Overall, we report targeting CD38 may be worth pursuing in clinical trials.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:label>3.<\/jats:label>\n                  <jats:title>Key Messages<\/jats:title>\n                  <jats:list list-type=\"order\">\n                    <jats:list-item>\n                      <jats:p>Monocyte subsets express markers of activation in circulation and HS lesions<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Targeting CD38 may be a viable strategy for treating systemic and cutaneous inflammation in patients with HS<\/jats:p>\n                    <\/jats:list-item>\n                  <\/jats:list>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:label>4.<\/jats:label>\n                  <jats:title>Capsule Summary<\/jats:title>\n                  <jats:p>Dysregulated immune cells in patients with HS express CD38 and may be targeting by anti-CD38 immunotherapy.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2023.01.27.525867","type":"posted-content","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T21:05:10Z","timestamp":1674939910000},"source":"Crossref","is-referenced-by-count":1,"title":["Dysregulated CD38 expression in blood and skin immune cells of patients with hidradenitis 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