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Using long sequence reads from haploid clones from a mutation accumulation experiment, we detect\n                  <jats:italic>var<\/jats:italic>\n                  diversity inconsistent with simple chromosomal inheritance. We discover putatively circular DNA that is strongly enriched for\n                  <jats:italic>var<\/jats:italic>\n                  genes, which exist in multiple alleles per locus separated by recombination and indel events. Extrachromosomal DNA likely contributes to rapid antigenic diversification in\n                  <jats:italic>P. falciparum<\/jats:italic>\n                  .\n                <\/jats:p>","DOI":"10.1101\/2023.02.02.526885","type":"posted-content","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T22:50:14Z","timestamp":1675378214000},"source":"Crossref","is-referenced-by-count":3,"title":["Antigenic diversity in malaria parasites is maintained on extrachromosomal DNA"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3244-4250","authenticated-orcid":false,"given":"Emily R.","family":"Ebel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5025-1292","authenticated-orcid":false,"given":"Bernard Y.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7821-260X","authenticated-orcid":false,"given":"Marina","family":"McDew-White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-7700","authenticated-orcid":false,"given":"Elizabeth S.","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0191-0204","authenticated-orcid":false,"given":"Timothy J.C.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-9130","authenticated-orcid":false,"given":"Dmitri A.","family":"Petrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2023020502250581000_2023.02.02.526885v1.1","unstructured":"World Health Organization. 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