{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:24:53Z","timestamp":1768562693046,"version":"3.49.0"},"posted":{"date-parts":[[2023,2,7]]},"group-title":"Epidemiology","reference-count":14,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,12,21]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to\n                  <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                  antigens. In a three-year longitudinal cohort in a high transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 (95% CI: 1.6, 3.5) per 100 person-years.\n                <\/jats:p>","DOI":"10.1101\/2023.02.04.23285360","type":"posted-content","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T21:40:16Z","timestamp":1675806016000},"source":"Crossref","is-referenced-by-count":2,"title":["Seroreversion to\n                  <i>Chlamydia trachomatis<\/i>\n                  Pgp3 antigen among children in a hyperendemic region of Amhara, Ethiopia"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-5765","authenticated-orcid":false,"given":"Christine","family":"Tedijanto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4967-9627","authenticated-orcid":false,"given":"Solomon","family":"Aragie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1856-3165","authenticated-orcid":false,"given":"Sarah","family":"Gwyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9887-5993","authenticated-orcid":false,"given":"Dionna M.","family":"Wittberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0736-2955","authenticated-orcid":false,"given":"Taye","family":"Zeru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zerihun","family":"Tadesse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambahun","family":"Chernet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel J.B.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5741-8537","authenticated-orcid":false,"given":"Scott D.","family":"Nash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8216-0240","authenticated-orcid":false,"given":"Thomas M.","family":"Lietman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana L.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7118-1457","authenticated-orcid":false,"given":"Jeremy D.","family":"Keenan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6105-7295","authenticated-orcid":false,"given":"Benjamin F.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023122523300649000_2023.02.04.23285360v2.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005080"},{"issue":"9","key":"2023122523300649000_2023.02.04.23285360v2.2","doi-asserted-by":"crossref","first-page":"e0008316","DOI":"10.1371\/journal.pntd.0008316","article-title":"The use of serology for trachoma surveillance: Current status and priorities for future investigation","volume":"14","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"2023122523300649000_2023.02.04.23285360v2.3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001873"},{"key":"2023122523300649000_2023.02.04.23285360v2.4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003555"},{"issue":"1","key":"2023122523300649000_2023.02.04.23285360v2.5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4269\/ajtmh.20-0777","article-title":"Population-Based Prevalence of Chlamydia trachomatis Infection and Antibodies in Four Districts with Varying Levels of Trachoma Endemicity in Amhara, Ethiopia","volume":"104","year":"2021","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"2023122523300649000_2023.02.04.23285360v2.6","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1038\/s41467-023-38940-5","article-title":"Monitoring transmission intensity of trachoma with serology","volume":"14","year":"2023","journal-title":"Nat Commun"},{"key":"2023122523300649000_2023.02.04.23285360v2.7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/1471-2334-14-216","article-title":"Longitudinal analysis of antibody responses to trachoma antigens before and after mass drug administration","volume":"14","year":"2014","journal-title":"BMC Infect Dis"},{"issue":"7","key":"2023122523300649000_2023.02.04.23285360v2.8","doi-asserted-by":"crossref","first-page":"e0010629","DOI":"10.1371\/journal.pntd.0010629","article-title":"Risk of seroconversion and seroreversion of antibodies to Chlamydia trachomatis pgp3 in a longitudinal cohort of children in a low trachoma prevalence district in Tanzania","volume":"16","year":"2022","journal-title":"PLoS Negl Trop Dis"},{"key":"2023122523300649000_2023.02.04.23285360v2.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21127-0"},{"issue":"1","key":"2023122523300649000_2023.02.04.23285360v2.10","doi-asserted-by":"crossref","first-page":"15225","DOI":"10.1038\/s41598-020-71833-x","article-title":"The effect of Mass Drug Administration for trachoma on antibodies to Chlamydia trachomatis pgp3 in children","volume":"10","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"2023122523300649000_2023.02.04.23285360v2.11","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1016\/S2214-109X(21)00409-5","article-title":"Water, sanitation, and hygiene for control of trachoma in Ethiopia (WUHA): a two-arm, parallel-group, cluster-randomised trial","volume":"10","year":"2022","journal-title":"Lancet Glob Health"},{"key":"2023122523300649000_2023.02.04.23285360v2.12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005230"},{"issue":"6","key":"2023122523300649000_2023.02.04.23285360v2.13","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.4269\/ajtmh.19-0450","article-title":"Progress to Eliminate Trachoma as a Public Health Problem in Amhara National Regional State, Ethiopia: Results of 152 Population-Based Surveys","volume":"101","year":"2019","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"2023122523300649000_2023.02.04.23285360v2.14","doi-asserted-by":"crossref","first-page":"e0010273","DOI":"10.1371\/journal.pntd.0010273","article-title":"Predicting future community-level ocular Chlamydia trachomatis infection prevalence using serological, clinical, molecular, and geospatial data","volume":"16","year":"2022","journal-title":"PLoS Negl Trop Dis"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2023.02.04.23285360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:26:30Z","timestamp":1768505190000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2023.02.04.23285360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,7]]},"references-count":14,"URL":"https:\/\/doi.org\/10.1101\/2023.02.04.23285360","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1093\/infdis\/jiad602","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2023,2,7]]},"subtype":"preprint"}}