{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:24:49Z","timestamp":1768562689932,"version":"3.49.0"},"posted":{"date-parts":[[2023,2,8]]},"group-title":"Public and Global Health","reference-count":34,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,2,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  After three years with no confirmed cholera cases in Haiti, an outbreak of\n                  <jats:italic>Vibrio cholerae<\/jats:italic>\n                  O1 emerged in October 2022. Levels of pre-existing antibodies provide an estimate of prior immunologic exposure, reveal potentially relevant immune responses, and set a baseline for future serosurveillance. We analyzed dried blood spots collected in 2021 from a population-weighted representative cross-sectional serosurvey in two communes in the Ouest Department of Haiti. We found lower levels of circulating IgG and IgA antibodies against\n                  <jats:italic>V. cholerae<\/jats:italic>\n                  lipopolysaccharide (LPS, IgG and IgA p&lt;0.0001) in those below 5 years of age compared to those five years and older. Among a subset of patients with higher titers of antibodies, we were unable to detect any functional (vibriocidal) antibodies. In conclusion, the lack of detectable functional antibodies, and age-discordant levels of\n                  <jats:italic>V. cholerae<\/jats:italic>\n                  LPS IgG, suggest that populations in Haiti may be highly susceptible to cholera disease, especially among young children.\n                <\/jats:p>","DOI":"10.1101\/2023.02.06.23285537","type":"posted-content","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T15:20:34Z","timestamp":1675869634000},"source":"Crossref","is-referenced-by-count":0,"title":["A population-based serological survey of\n                  <i>Vibrio cholerae<\/i>\n                  antibody titers in Ouest Department, Haiti in the year prior to the 2022 cholera outbreak"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6236-5636","authenticated-orcid":false,"given":"Christy H.","family":"Clutter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly B.","family":"Klarman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youseline","family":"Cajusma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie T.","family":"Cato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Abu","family":"Sayeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Brinkley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6670-4743","authenticated-orcid":false,"given":"Owen","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantale","family":"Baril","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. Madsen","family":"Beau De Rochars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-9077","authenticated-orcid":false,"given":"Andrew S.","family":"Azman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5337-9024","authenticated-orcid":false,"given":"Maureen T.","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9437-1907","authenticated-orcid":false,"given":"Derek","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8401-0801","authenticated-orcid":false,"given":"Daniel T.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-2624","authenticated-orcid":false,"given":"Eric J.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023021101401116000_2023.02.06.23285537v1.1","doi-asserted-by":"crossref","unstructured":"Lantagne D , Balakrish Nair G , Lanata CF , Cravioto A. 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