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Using our murine model of maternal schistosomiasis, when immunized, males from infected mothers had a lower frequency of antigen-specific germinal center B cells and downregulation of transcripts downstream of BCR signaling compared to males from uninfected mothers. This is driven by a reduction in developing B cell populations within the bone marrow of pups from infected mothers. Males from infected mothers were impacted to a greater extent than their female littermate counterparts. We found this defect to be caused by aberrant expression of the long non-coding RNA\n                  <jats:italic>Xist<\/jats:italic>\n                  in males leading to dysregulated Ig\u03b1 expression on developing B cells. This, for the first time, links dysfunctional BCR signaling with\n                  <jats:italic>Xist<\/jats:italic>\n                  expression, while also proposing a detrimental function for\n                  <jats:italic>Xist<\/jats:italic>\n                  expression in males.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>One sentence summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Xist<\/jats:italic>\n                    expression in males decreases BCR reactivity.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2023.02.13.528357","type":"posted-content","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:15:16Z","timestamp":1676333716000},"source":"Crossref","is-referenced-by-count":0,"title":["Maternal infection causes dysfunctional BCR signaling in male offspring due to aberrant Xist expression"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4567-6659","authenticated-orcid":false,"given":"Lisa C.","family":"Gibbs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan M.","family":"Oviedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartholomew N.","family":"Ondigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8382-2960","authenticated-orcid":false,"given":"Keke C.","family":"Fairfax","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023021523000756000_2023.02.13.528357v1.1","doi-asserted-by":"crossref","unstructured":"U. 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