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The most dramatic effect on the transcriptome was the upregulation of genes expressed during oogenesis and downregulation of genes associated with male gametogenesis. Among the detrimental effects of ascr#10 on hermaphrodites is the increased risk of persistent infections caused by pathological pharyngeal hypertrophy. Our results reveal a way in which social signals help to resolve the inherent conflict between spermatogenesis and oogenesis in a simultaneous hermaphrodite, presumably to optimally align reproductive function to the presence of potential mating partners. They also show that the beneficial effects of the pheromone are accompanied by harmful consequences that reduce lifespan.\n                <\/jats:p>","DOI":"10.1101\/2023.02.17.528976","type":"posted-content","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T23:25:10Z","timestamp":1676762710000},"source":"Crossref","is-referenced-by-count":1,"title":["A\n                  <i>C. elegans<\/i>\n                  male pheromone feminizes germline gene expression in hermaphrodites and imposes life-history costs"],"prefix":"10.64898","author":[{"given":"David","family":"Angeles-Albores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin Z.","family":"Aprison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Dzitoyeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-3679","authenticated-orcid":false,"given":"Ilya","family":"Ruvinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023022103250724000_2023.02.17.528976v1.1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.117.300080"},{"key":"2023022103250724000_2023.02.17.528976v1.2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1712387115"},{"key":"2023022103250724000_2023.02.17.528976v1.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2015576119"},{"key":"2023022103250724000_2023.02.17.528976v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.07.034"},{"key":"2023022103250724000_2023.02.17.528976v1.5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005729"},{"key":"2023022103250724000_2023.02.17.528976v1.6","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1016\/j.cub.2016.08.024","article-title":"Sexually Antagonistic Male Signals Manipulate Germline and Soma of C. elegans Hermaphrodites","volume":"26","year":"2016","journal-title":"Curr Biol"},{"key":"2023022103250724000_2023.02.17.528976v1.7","doi-asserted-by":"crossref","first-page":"e46418","DOI":"10.7554\/eLife.46418","article-title":"Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes","volume":"8","year":"2019","journal-title":"Elife"},{"key":"2023022103250724000_2023.02.17.528976v1.8","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s43587-022-00276-y","article-title":"Males induce premature demise of the opposite sex by multifaceted strategies","volume":"2","year":"2022","journal-title":"Nature Aging"},{"key":"2023022103250724000_2023.02.17.528976v1.9","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41467-023-36040-y","article-title":"Sex-specificity of the C. elegans metabolome","volume":"14","year":"2023","journal-title":"Nat Commun"},{"key":"2023022103250724000_2023.02.17.528976v1.10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.5.2480"},{"key":"2023022103250724000_2023.02.17.528976v1.11","unstructured":"Charnov EL . 1982. 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