{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:56:06Z","timestamp":1790661366588,"version":"4.1.0"},"posted":{"date-parts":[[2023,2,23]]},"group-title":"Microbiology","reference-count":54,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,2,23]]},"abstract":"<jats:title>Summary<\/jats:title>\n                <jats:p>\n                  Fungal invasion of the oral epithelium is central to the pathogenesis of oropharyngeal candidiasis (OPC).\n                  <jats:italic>Candida albicans<\/jats:italic>\n                  invades the oral epithelium by receptor-induced endocytosis but this process is incompletely understood. We found that\n                  <jats:italic>C. albicans<\/jats:italic>\n                  infection of oral epithelial cells induces c-Met to form a multi-protein complex with E-cadherin and the epidermal growth factor receptor (EGFR). E-cadherin is necessary for\n                  <jats:italic>C. albicans<\/jats:italic>\n                  to activate both c-Met and EGFR and to induce the endocytosis of\n                  <jats:italic>C. albicans<\/jats:italic>\n                  . Proteomics analysis revealed that c-Met interacts with\n                  <jats:italic>C. albicans<\/jats:italic>\n                  Hyr1, Als3 and Ssa1. Both Hyr1 and Als3 were required for\n                  <jats:italic>C. albicans<\/jats:italic>\n                  stimulation of c-Met and EGFR in oral epithelial cells in vitro and for full virulence during OPC in mice. Treating mice with small molecule inhibitors of c-Met and EGFR ameliorated OPC, demonstrating the potential therapeutic efficacy of blocking these host receptors for\n                  <jats:italic>C. albicans<\/jats:italic>\n                  .\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Graphical abstract<\/jats:title>\n                  <jats:fig id=\"ufig1\" position=\"float\" fig-type=\"figure\" orientation=\"portrait\">\n                    <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"529756v1_ufig1\" position=\"float\" orientation=\"portrait\"\/>\n                  <\/jats:fig>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:list list-type=\"bullet\">\n                    <jats:list-item>\n                      <jats:p>\n                        c-Met is an oral epithelial cell receptor for\n                        <jats:italic>Candida albicans<\/jats:italic>\n                      <\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>\n                        <jats:italic>C. albicans<\/jats:italic>\n                        infection causes c-Met and the epidermal growth factor receptor (EGFR) to form a complex with E-cadherin, which is required for c-Met and EGFR function\n                      <\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>\n                        <jats:italic>C. albicans<\/jats:italic>\n                        Hyr1 and Als3 interact with c-Met and EGFR, inducing oral epithelial cell endocytosis and virulence during oropharyngeal candidiasis\n                      <\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Dual blockade of c-Met and EGFR ameliorates oropharyngeal candidiasis<\/jats:p>\n                    <\/jats:list-item>\n                  <\/jats:list>\n                <\/jats:sec>","DOI":"10.1101\/2023.02.23.529756","type":"posted-content","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T22:40:20Z","timestamp":1677192020000},"source":"Crossref","is-referenced-by-count":3,"title":["<i>Candida albicans<\/i>\n                  stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection"],"prefix":"10.64898","author":[{"given":"Quynh T.","family":"Phan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma V.","family":"Solis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max 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