{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:45:22Z","timestamp":1776206722098,"version":"3.50.1"},"posted":{"date-parts":[[2023,3,1]]},"group-title":"Cancer Biology","reference-count":93,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Reduced responsiveness of precursor B-acute lymphoblastic leukemia (BCP-ALL) to chemotherapy can be inferred when leukemia cells persist after 28 days of initial treatment. Survival of these long-term persister (LTP) \/ minimal residual disease (MRD) cells is partly due to bone marrow stromal cells that protect them under conditions of chemotherapy stress. We used RNA-seq to analyse BCP-ALL cells that survived a long-term, 30-day vincristine chemotherapy treatment while in co-culture with bone marrow stromal cells. RNAs of as many as 10% of the protein-encoding genes were differentially expressed. There was substantial overlap with genes associated with MRD cell persistence reported in other studies. The top pathway regulated in the LTP cells was that involving p53, a master regulator of a spectrum of responses relevant to drug resistance and cytotoxic drug exposure including control of autophagy. We tested a select number of genes for contribution to BCP-ALL cell survival using Cas9\/CRISPR in a 2-step selection, initially for overall effect on cell fitness, followed by 21 days of exposure to vincristine. Many genes involved in autophagy and lysosomal function were found to contribute to survival both at steady-state and during drug treatment. We also identified MYH9, NCSTN and KIAA2013 as specific genes contributing to fitness of BCP-ALL cells. CD44 was not essential for growth under steady state conditions but was needed for survival of vincristine treatment. Finally, although the drug transporter ABCC1\/MRP1 is not overexpressed in BCP-ALL, a functional gene was needed for DTP cells to survive treatment with vincristine. This suggests that addition of possible ABCC1 inhibitors during induction therapy could provide benefit in eradication of minimal residual disease in patients treated with a chemotherapy regimen that includes vincristine.<\/jats:p>","DOI":"10.1101\/2023.02.28.530540","type":"posted-content","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T10:20:10Z","timestamp":1677925210000},"source":"Crossref","is-referenced-by-count":4,"title":["Drug-tolerant persister B-cell precursor acute lymphoblastic leukemia cells"],"prefix":"10.64898","author":[{"given":"Mingfeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2769-2273","authenticated-orcid":false,"given":"Nora","family":"Heisterkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023030803301491000_2023.02.28.530540v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.53"},{"key":"2023030803301491000_2023.02.28.530540v1.2","doi-asserted-by":"crossref","unstructured":"Bhm JW , Sia KCS , Jones C , Evans K , Mariana A , Pang I , et al. Combination efficacy of ruxolitinib with standard-of-care drugs in CRLF2-rearranged Ph-like acute lymphoblastic leukemia. Leukemia. 2021.","DOI":"10.1038\/s41375-021-01248-8"},{"key":"2023030803301491000_2023.02.28.530540v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.11.001"},{"key":"2023030803301491000_2023.02.28.530540v1.4","doi-asserted-by":"crossref","unstructured":"Contreras Yametti GP , Ostrow TH , Jasinski S , Raetz EA , Carroll WL , Evensen NA. Minimal Residual Disease in Acute Lymphoblastic Leukemia: Current Practice and Future Directions. Cancers (Basel). 2021;13(8).","DOI":"10.3390\/cancers13081847"},{"key":"2023030803301491000_2023.02.28.530540v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.251"},{"key":"2023030803301491000_2023.02.28.530540v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2714"},{"issue":"3","key":"2023030803301491000_2023.02.28.530540v1.7","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbamcr.2015.08.003","article-title":"The role of microenvironment and immunity in drug response in leukemia","volume":"1863","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"2023030803301491000_2023.02.28.530540v1.8","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.175"},{"key":"2023030803301491000_2023.02.28.530540v1.9","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3409"},{"issue":"1","key":"2023030803301491000_2023.02.28.530540v1.10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13046-018-0721-7","article-title":"Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008","volume":"37","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"2023030803301491000_2023.02.28.530540v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.02.003"},{"key":"2023030803301491000_2023.02.28.530540v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/nature14231"},{"issue":"19","key":"2023030803301491000_2023.02.28.530540v1.13","doi-asserted-by":"crossref","first-page":"9519","DOI":"10.7150\/thno.65398","article-title":"Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemia","volume":"11","year":"2021","journal-title":"Theranostics"},{"key":"2023030803301491000_2023.02.28.530540v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.11.002"},{"key":"2023030803301491000_2023.02.28.530540v1.15","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0843-6"},{"key":"2023030803301491000_2023.02.28.530540v1.16","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0554-4"},{"key":"2023030803301491000_2023.02.28.530540v1.17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-406272"},{"issue":"18","key":"2023030803301491000_2023.02.28.530540v1.18","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1182\/bloodadvances.2020001592","article-title":"CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia","volume":"4","year":"2020","journal-title":"Blood Adv"},{"issue":"6","key":"2023030803301491000_2023.02.28.530540v1.19","first-page":"5039","article-title":"Support of acute lymphoblastic leukemia cells by nonmalignant bone marrow stromal cells","volume":"17","year":"2019","journal-title":"Oncol Lett"},{"key":"2023030803301491000_2023.02.28.530540v1.20","doi-asserted-by":"publisher","DOI":"10.4161\/onci.20249"},{"key":"2023030803301491000_2023.02.28.530540v1.21","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121482"},{"issue":"5","key":"2023030803301491000_2023.02.28.530540v1.22","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/bjh.15252","article-title":"Effective Response Metric: a novel tool to predict relapse in childhood acute lymphoblastic leukaemia using time-series gene expression profiling","volume":"181","year":"2018","journal-title":"Br J Haematol"},{"key":"2023030803301491000_2023.02.28.530540v1.23","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2558"},{"key":"2023030803301491000_2023.02.28.530540v1.24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"2023030803301491000_2023.02.28.530540v1.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2004.06.006"},{"issue":"1","key":"2023030803301491000_2023.02.28.530540v1.26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.trecan.2020.08.007","article-title":"Mice Are Not Humans: The Case of p53","volume":"7","year":"2021","journal-title":"Trends Cancer"},{"key":"2023030803301491000_2023.02.28.530540v1.27","doi-asserted-by":"publisher","DOI":"10.1021\/mp200261n"},{"key":"2023030803301491000_2023.02.28.530540v1.28","doi-asserted-by":"crossref","unstructured":"de Klerk DJ , Honeywell RJ , Jansen G , Peters GJ. Transporter and Lysosomal Mediated (Multi)drug Resistance to Tyrosine Kinase Inhibitors and Potential Strategies to Overcome Resistance. Cancers (Basel). 2018;10(12).","DOI":"10.3390\/cancers10120503"},{"key":"2023030803301491000_2023.02.28.530540v1.29","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3520"},{"key":"2023030803301491000_2023.02.28.530540v1.30","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.349"},{"key":"2023030803301491000_2023.02.28.530540v1.31","doi-asserted-by":"publisher","DOI":"10.1002\/path.5222"},{"key":"2023030803301491000_2023.02.28.530540v1.32","doi-asserted-by":"crossref","unstructured":"Khoo XH , Paterson IC , Goh BH , Lee WL. Cisplatin-Resistance in Oral Squamous Cell Carcinoma: Regulation by Tumor Cell-Derived Extracellular Vesicles. Cancers (Basel). 2019;11(8).","DOI":"10.3390\/cancers11081166"},{"key":"2023030803301491000_2023.02.28.530540v1.33","doi-asserted-by":"publisher","DOI":"10.1126\/science.1257132"},{"key":"2023030803301491000_2023.02.28.530540v1.34","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/1471-2407-12-469","article-title":"Vincristine enhances amoeboid-like motility via GEF-H1\/RhoA\/ROCK\/Myosin light chain signaling in MKN45 cells","volume":"12","year":"2012","journal-title":"BMC Cancer"},{"issue":"24","key":"2023030803301491000_2023.02.28.530540v1.35","doi-asserted-by":"crossref","first-page":"e112677","DOI":"10.15252\/embj.2022112677","article-title":"Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair","volume":"41","year":"2022","journal-title":"EMBO J"},{"key":"2023030803301491000_2023.02.28.530540v1.36","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.80"},{"key":"2023030803301491000_2023.02.28.530540v1.37","doi-asserted-by":"crossref","first-page":"606370","DOI":"10.3389\/fonc.2021.606370","article-title":"Prognostic Relevance of Expression of EMP1, CASP1, and NLRP3 Genes in Pediatric B-Lineage Acute Lymphoblastic Leukemia","volume":"11","year":"2021","journal-title":"Front Oncol"},{"key":"2023030803301491000_2023.02.28.530540v1.38","first-page":"e7","article-title":"Structure, regulation and related diseases of the actin-binding protein gelsolin","volume":"20","year":"2019","journal-title":"Expert Rev Mol Med"},{"key":"2023030803301491000_2023.02.28.530540v1.39","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200500417"},{"key":"2023030803301491000_2023.02.28.530540v1.40","doi-asserted-by":"crossref","first-page":"795838","DOI":"10.3389\/fcell.2021.795838","article-title":"Regulation of Mitochondrial Function by the Actin Cytoskeleton","volume":"9","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2023030803301491000_2023.02.28.530540v1.41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203868"},{"key":"2023030803301491000_2023.02.28.530540v1.42","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1540"},{"key":"2023030803301491000_2023.02.28.530540v1.43","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-00914-5"},{"issue":"5","key":"2023030803301491000_2023.02.28.530540v1.44","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/febs.15844","article-title":"The duality of PRDM proteins: epigenetic and structural perspectives","volume":"289","year":"2022","journal-title":"FEBS J"},{"issue":"1","key":"2023030803301491000_2023.02.28.530540v1.45","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ygyno.2020.01.013","article-title":"Quantitative proteomic analysis identifies novel regulators of methotrexate resistance in choriocarcinoma","volume":"157","year":"2020","journal-title":"Gynecol Oncol"},{"issue":"1","key":"2023030803301491000_2023.02.28.530540v1.46","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41420-021-00555-4","article-title":"Methyltransferase-like protein 7A (METTL7A) promotes cell survival and osteogenic differentiation under metabolic stress","volume":"7","year":"2021","journal-title":"Cell Death Discov"},{"key":"2023030803301491000_2023.02.28.530540v1.47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06739.x"},{"issue":"35","key":"2023030803301491000_2023.02.28.530540v1.48","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1038\/onc.2015.525","article-title":"High expression of connective tissue growth factor accelerates dissemination of leukaemia","volume":"35","year":"2016","journal-title":"Oncogene"},{"key":"2023030803301491000_2023.02.28.530540v1.49","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.007112"},{"key":"2023030803301491000_2023.02.28.530540v1.50","doi-asserted-by":"crossref","unstructured":"Fei F , Zhang M , Tarighat SS , Joo EJ , Yang L , Heisterkamp N. Galectin-1 and Galectin-3 in B-Cell Precursor Acute Lymphoblastic Leukemia. Int J Mol Sci. 2022;23(22).","DOI":"10.3390\/ijms232214359"},{"key":"2023030803301491000_2023.02.28.530540v1.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.053"},{"key":"2023030803301491000_2023.02.28.530540v1.52","doi-asserted-by":"crossref","unstructured":"An Q , Dong Y , Cao Y , Pan X , Xue Y , Zhou Y , et al. Myh9 Plays an Essential Role in the Survival and Maintenance of Hematopoietic Stem\/Progenitor Cells. Cells. 2022;11(12).","DOI":"10.3390\/cells11121865"},{"issue":"8","key":"2023030803301491000_2023.02.28.530540v1.53","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/j.celrep.2018.04.087","article-title":"Myosin IIa Promotes Antibody Responses by Regulating B Cell Activation, Acquisition of Antigen, and Proliferation","volume":"23","year":"2018","journal-title":"Cell Rep"},{"key":"2023030803301491000_2023.02.28.530540v1.54","doi-asserted-by":"crossref","unstructured":"Chang F , Kong SJ , Wang L , Choi BK , Lee H , Kim C , et al. Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells. Int J Mol Sci. 2020;21(10).","DOI":"10.3390\/ijms21103460"},{"key":"2023030803301491000_2023.02.28.530540v1.55","doi-asserted-by":"publisher","DOI":"10.1038\/79063"},{"key":"2023030803301491000_2023.02.28.530540v1.56","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1A0815-342R"},{"issue":"1","key":"2023030803301491000_2023.02.28.530540v1.57","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1053\/j.seminoncol.2022.01.005","article-title":"Pathogenic signaling in multiple myeloma","volume":"49","year":"2022","journal-title":"Semin Oncol"},{"key":"2023030803301491000_2023.02.28.530540v1.58","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.338"},{"issue":"12","key":"2023030803301491000_2023.02.28.530540v1.59","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1038\/leu.2017.160","article-title":"Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy","volume":"31","year":"2017","journal-title":"Leukemia"},{"key":"2023030803301491000_2023.02.28.530540v1.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.10.003"},{"key":"2023030803301491000_2023.02.28.530540v1.61","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2572"},{"issue":"1","key":"2023030803301491000_2023.02.28.530540v1.62","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1038\/s41467-022-33142-x","article-title":"Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma","volume":"13","year":"2022","journal-title":"Nat Commun"},{"key":"2023030803301491000_2023.02.28.530540v1.63","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2188-x"},{"key":"2023030803301491000_2023.02.28.530540v1.64","doi-asserted-by":"publisher","DOI":"10.1038\/nature21076"},{"issue":"1","key":"2023030803301491000_2023.02.28.530540v1.65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jms.1696","article-title":"Defining the membrane proteome of NK cells","volume":"45","year":"2010","journal-title":"J Mass Spectrom"},{"key":"2023030803301491000_2023.02.28.530540v1.66","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar2663"},{"key":"2023030803301491000_2023.02.28.530540v1.67","unstructured":"Summary KDG. [Available from: KIAA2013 DepMap Gene Summary"},{"key":"2023030803301491000_2023.02.28.530540v1.68","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fnmol.2019.00224","article-title":"Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome","volume":"12","year":"2019","journal-title":"Front Mol Neurosci"},{"issue":"3","key":"2023030803301491000_2023.02.28.530540v1.69","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s43018-020-0037-3","article-title":"Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia","volume":"1","year":"2020","journal-title":"Nat Cancer"},{"key":"2023030803301491000_2023.02.28.530540v1.70","doi-asserted-by":"crossref","unstructured":"Moore G , Annett S , McClements L , Robson T. Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives. Cells. 2020;9(6).","DOI":"10.3390\/cells9061503"},{"key":"2023030803301491000_2023.02.28.530540v1.71","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03272.2003"},{"key":"2023030803301491000_2023.02.28.530540v1.72","doi-asserted-by":"publisher","DOI":"10.1038\/nature09999"},{"key":"2023030803301491000_2023.02.28.530540v1.73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1916645117"},{"issue":"2","key":"2023030803301491000_2023.02.28.530540v1.74","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/path.5510","article-title":"The choroid plexus stroma constitutes a sanctuary for paediatric B-cell precursor acute lymphoblastic leukaemia in the central nervous system","volume":"252","year":"2020","journal-title":"J Pathol"},{"key":"2023030803301491000_2023.02.28.530540v1.75","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1617"},{"key":"2023030803301491000_2023.02.28.530540v1.76","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-324004"},{"issue":"12","key":"2023030803301491000_2023.02.28.530540v1.77","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1182\/blood.2020006343","article-title":"CD44 loss of function sensitizes AML cells to the BCL-2 inhibitor venetoclax by decreasing CXCL12-driven survival cues","volume":"138","year":"2021","journal-title":"Blood"},{"issue":"3","key":"2023030803301491000_2023.02.28.530540v1.78","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.exphem.2015.12.001","article-title":"CD44 promotes chemoresistance in T-ALL by increased drug efflux","volume":"44","year":"2016","journal-title":"Exp Hematol"},{"key":"2023030803301491000_2023.02.28.530540v1.79","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.2147\/OTT.S140488","article-title":"The translational expression of ABCA2 and ABCA3 is a strong prognostic biomarker for multidrug resistance in pediatric acute lymphoblastic leukemia","volume":"10","year":"2017","journal-title":"Onco Targets Ther"},{"issue":"1","key":"2023030803301491000_2023.02.28.530540v1.80","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4161\/cbt.26603","article-title":"mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2","volume":"15","year":"2014","journal-title":"Cancer Biol Ther"},{"issue":"1","key":"2023030803301491000_2023.02.28.530540v1.81","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/MPH.0000000000001613","article-title":"Characterizing Iranian Pediatric Patients With Relapsed Acute Lymphoblastic Leukemia Through Gene Expression Profiling of Common ATP Binding Cassette Transporters Subfamily C","volume":"42","year":"2020","journal-title":"J Pediatr Hematol Oncol"},{"key":"2023030803301491000_2023.02.28.530540v1.82","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0005-8"},{"issue":"9","key":"2023030803301491000_2023.02.28.530540v1.83","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1021\/acs.jmedchem.8b01821","article-title":"Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach","volume":"62","year":"2019","journal-title":"J Med Chem"},{"key":"2023030803301491000_2023.02.28.530540v1.84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exphem.2018.09.006","article-title":"A rare subgroup of leukemia stem cells harbors relapse-inducing potential in acute lymphoblastic leukemia","volume":"69","year":"2019","journal-title":"Exp Hematol"},{"key":"2023030803301491000_2023.02.28.530540v1.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.12.002"},{"issue":"8","key":"2023030803301491000_2023.02.28.530540v1.86","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/s43018-021-00219-3","article-title":"Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia","volume":"2","year":"2021","journal-title":"Nat Cancer"},{"key":"2023030803301491000_2023.02.28.530540v1.87","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11568-0"},{"issue":"12","key":"2023030803301491000_2023.02.28.530540v1.88","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41568-019-0210-0","article-title":"Context-dependent roles of complement in cancer","volume":"19","year":"2019","journal-title":"Nat Rev Cancer"},{"issue":"6611","key":"2023030803301491000_2023.02.28.530540v1.89","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1126\/science.abn0478","article-title":"Lineage plasticity in prostate cancer depends on JAK\/STAT inflammatory signaling","volume":"377","year":"2022","journal-title":"Science"},{"issue":"4","key":"2023030803301491000_2023.02.28.530540v1.90","first-page":"1164","article-title":"The bone marrow microenvironment as a mediator of chemoresistance in acute lymphoblastic leukemia","volume":"2","year":"2019","journal-title":"Cancer Drug Resist"},{"key":"2023030803301491000_2023.02.28.530540v1.91","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1154"},{"key":"2023030803301491000_2023.02.28.530540v1.92","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.02.020"},{"key":"2023030803301491000_2023.02.28.530540v1.93","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.04.026"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2023.02.28.530540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:20:06Z","timestamp":1768450806000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2023.02.28.530540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":93,"URL":"https:\/\/doi.org\/10.1101\/2023.02.28.530540","relation":{},"subject":[],"published":{"date-parts":[[2023,3,1]]},"subtype":"preprint"}}