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Using high spatiotemporal resolution, we mapped and quantified the neurophysiological effects of sensory flicker in human subjects undergoing presurgical intracranial seizure monitoring. We found that flicker modulates both local field potential and single neurons in higher cognitive regions, including the medial temporal lobe and prefrontal cortex, and that local field potential modulation is likely mediated via resonance of involved circuits. We then assessed how flicker affects pathological neural activity, specifically interictal epileptiform discharges, a biomarker of epilepsy also implicated in Alzheimer\u2019s and other diseases. In our patient population with focal seizure onsets, sensory flicker decreased the rate interictal epileptiform discharges. Our findings support the use of sensory flicker to modulate deeper cortical structures and mitigate pathological activity in humans.<\/jats:p>","DOI":"10.1101\/2023.03.14.23286691","type":"posted-content","created":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T03:49:50Z","timestamp":1679197790000},"source":"Crossref","is-referenced-by-count":2,"title":["Multisensory Flicker Modulates Widespread Brain Networks and Reduces Interictal Epileptiform Discharges in Humans"],"prefix":"10.64898","author":[{"given":"Lou T.","family":"Blanpain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Y.","family":"Walelign","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian T.","family":"Cabaniss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon T.","family":"Willie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabelle C.","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023032010451143000_2023.03.14.23286691v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.08.004"},{"key":"2023032010451143000_2023.03.14.23286691v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2003.10.012"},{"key":"2023032010451143000_2023.03.14.23286691v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.020"},{"key":"2023032010451143000_2023.03.14.23286691v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.046"},{"key":"2023032010451143000_2023.03.14.23286691v1.5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuron.2018.02.029","article-title":"Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer\u2019s Disease","volume":"98","year":"2018","journal-title":"Neuron"},{"key":"2023032010451143000_2023.03.14.23286691v1.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408741111"},{"key":"2023032010451143000_2023.03.14.23286691v1.7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0349-18.2018"},{"key":"2023032010451143000_2023.03.14.23286691v1.8","first-page":"109","article-title":"Acoustic Enhancement of Sleep Slow Oscillations and Concomitant Memory Improvement in Older Adults","volume":"11","year":"2017","journal-title":"Front. 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