{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:08:52Z","timestamp":1784236132702,"version":"3.55.0"},"posted":{"date-parts":[[2023,3,17]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":13,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Post-exposure prophylaxis with doxycycline (doxyPEP) is being introduced to prevent bacterial sexually transmitted infections (STIs). Pre-existing tetracycline resistance in\n                  <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n                  limits doxyPEP effectiveness against gonorrhea, and selection for tetracycline resistant lineages may influence prevalence of resistance to other antimicrobials via selection for multi-drug resistant strains. Using genomic and antimicrobial susceptibility data from 5,644 clinical isolates of\n                  <jats:italic>N. gonorrhoeae<\/jats:italic>\n                  , we assessed the near-term impact of doxyPEP on\n                  <jats:italic>N. gonorrhoeae<\/jats:italic>\n                  antimicrobial resistance. We found that the impact on antimicrobial resistance is likely to be influenced by the strength of selection for plasmid-encoded and chromosomally-encoded tetracycline resistance, as isolates with high-level, plasmid-encoded resistance had lower minimum inhibitory concentrations to other antimicrobials compared to isolates with low-level tetracycline resistance. The impact of doxyPEP may differ across demographic groups and geographic regions within the United States due to variation in pre-existing tetracycline resistance.\n                <\/jats:p>","DOI":"10.1101\/2023.03.14.23287223","type":"posted-content","created":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T03:49:59Z","timestamp":1679197799000},"source":"Crossref","is-referenced-by-count":5,"title":["A genomic perspective on the near-term impact of doxycycline post-exposure prophylaxis on\n                  <i>Neisseria gonorrhoeae<\/i>\n                  antimicrobial resistance"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6255-690X","authenticated-orcid":false,"given":"Tatum D.","family":"Mortimer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-1314","authenticated-orcid":false,"given":"Yonatan H.","family":"Grad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2023032011350647000_2023.03.14.23287223v1.1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000216"},{"key":"2023032011350647000_2023.03.14.23287223v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30725-9"},{"key":"2023032011350647000_2023.03.14.23287223v1.3","unstructured":"Luetkemeyer A , Dombrowski J , Cohen S , et al. Doxycycline post-exposure prophylaxis for STI prevention among MSM and transgender women on HIV PrEP or living with HIV: high efficacy to reduce incident STI\u2019s in a randomized trial. In: JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. JOHN WILEY & SONS LTD THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W \u2026, 2022: 226\u2013226."},{"key":"2023032011350647000_2023.03.14.23287223v1.4","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001471"},{"key":"2023032011350647000_2023.03.14.23287223v1.5","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/127.4.461"},{"key":"2023032011350647000_2023.03.14.23287223v1.6","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.8.1864"},{"key":"2023032011350647000_2023.03.14.23287223v1.7","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13871"},{"key":"2023032011350647000_2023.03.14.23287223v1.8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00504-16"},{"key":"2023032011350647000_2023.03.14.23287223v1.9","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6950a6"},{"key":"2023032011350647000_2023.03.14.23287223v1.10","unstructured":"Department of Public Health announces first cases of concerning gonorrhea strain | Mass.gov. https:\/\/www.mass.gov\/news\/department-of-public-health-announces-first-cases-of-concerning-gonorrhea-strain (accessed March 8, 2023)."},{"key":"2023032011350647000_2023.03.14.23287223v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30157-8"},{"key":"2023032011350647000_2023.03.14.23287223v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09078-0"},{"key":"2023032011350647000_2023.03.14.23287223v1.13","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001769"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2023.03.14.23287223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:29:56Z","timestamp":1768505396000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2023.03.14.23287223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,17]]},"references-count":13,"URL":"https:\/\/doi.org\/10.1101\/2023.03.14.23287223","relation":{},"subject":[],"published":{"date-parts":[[2023,3,17]]},"subtype":"preprint"}}