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We recorded single neurons in the human medial temporal and frontal lobe while patients maintained multiple items in WM. In the hippocampus, TG-PAC was indicative of WM load and quality. We identified cells that selectively spiked during nonlinear interactions of theta phase and gamma amplitude. These PAC neurons were more strongly coordinated with frontal theta activity when cognitive control demand was high, and they introduced information-enhancing and behaviorally relevant noise correlations with persistently active neurons in the hippocampus. We show that TG-PAC integrates cognitive control and WM storage to improve the fidelity of WM representations and facilitate behavior.<\/jats:p>","DOI":"10.1101\/2023.04.05.535772","type":"posted-content","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T13:55:15Z","timestamp":1680789315000},"source":"Crossref","is-referenced-by-count":12,"title":["Control of working memory maintenance by theta-gamma phase amplitude coupling of human hippocampal neurons"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6516-7288","authenticated-orcid":false,"given":"Jonathan","family":"Daume","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-7314","authenticated-orcid":false,"given":"Jan","family":"Kaminski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-7689","authenticated-orcid":false,"given":"Andrea G. 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