{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:22:34Z","timestamp":1768566154494,"version":"3.49.0"},"posted":{"date-parts":[[2023,4,11]]},"group-title":"Neurology","reference-count":70,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Diffusion MRI (dMRI) can be used to probe microstructural properties of brain tissue and holds great promise as a means to non-invasively map Alzheimer\u2019s disease (AD) pathology. Few studies have evaluated multi-shell dMRI models, such as neurite orientation dispersion and density imaging (NODDI) and mean apparent propagator (MAP)-MRI, in cortical gray matter where many of the earliest histopathological changes occur in AD. Here, we investigated the relationship between CSF pTau\n                  <jats:sub>181<\/jats:sub>\n                  and A\u03b2\n                  <jats:sub>1\u201342<\/jats:sub>\n                  burden and regional cortical NODDI and MAP-MRI indices in 46 cognitively unimpaired individuals, 18 with mild cognitive impairment, and two with dementia (mean age: 71.8\u00b16.2 years) from the Alzheimer\u2019s Disease Neuroimaging Initiative. We compared findings to more conventional cortical thickness measures. Lower CSF A\u03b2\n                  <jats:sub>1\u201342<\/jats:sub>\n                  and higher pTau\n                  <jats:sub>181<\/jats:sub>\n                  were associated with cortical dMRI measures reflecting less hindered or restricted diffusion and greater diffusivity. Cortical dMRI measures were more widely associated with A\u03b2\n                  <jats:sub>1\u201342<\/jats:sub>\n                  than pTau\n                  <jats:sub>181<\/jats:sub>\n                  and better distinguished A\u03b2+ from A\u03b2-participants than pTau+\/- participants. Conversely, cortical thickness was more tightly linked with pTau\n                  <jats:sub>181<\/jats:sub>\n                  . dMRI associations mediated the relationship between CSF markers and delayed logical memory performance, commonly impaired in early AD. dMRI measures sensitive to early AD pathogenesis and microstructural damage may elucidate mechanisms underlying cognitive decline.\n                <\/jats:p>","DOI":"10.1101\/2023.04.10.23288366","type":"posted-content","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T23:45:13Z","timestamp":1681256713000},"source":"Crossref","is-referenced-by-count":1,"title":["Cortical microstructural associations with CSF amyloid and pTau"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-7443","authenticated-orcid":false,"given":"Talia M.","family":"Nir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio E.","family":"Villal\u00f3n-Reina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Salminen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia I.","family":"Thomopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Jahanshad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023041622400932000_2023.04.10.23288366v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"2023041622400932000_2023.04.10.23288366v1.2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"2023041622400932000_2023.04.10.23288366v1.3","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6467-9_11"},{"key":"2023041622400932000_2023.04.10.23288366v1.4","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-015-0132-3"},{"key":"2023041622400932000_2023.04.10.23288366v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.072"},{"key":"2023041622400932000_2023.04.10.23288366v1.6","doi-asserted-by":"crossref","unstructured":"Jelescu IO , Budde MD . 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