{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:06:42Z","timestamp":1768504002324,"version":"3.49.0"},"posted":{"date-parts":[[2023,5,9]]},"group-title":"Neuroscience","reference-count":90,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Traumatic brain injury (TBI) is a major public health concern particularly in adolescents who have a higher mortality and incidence of visual pathway injury compared to adult patients. Likewise, we have found disparities between adult and adolescent TBI outcomes in rodents. Most interestingly, adolescents suffer a prolonged apneic period immediately post injury leading to higher mortality; so, we implemented a brief oxygen exposure paradigm to circumvent this increased mortality. Adolescent male mice experienced a closed-head weight-drop TBI then were exposed to 100% O\n                  <jats:sub>2<\/jats:sub>\n                  until normal breathing returned or recovered in room air. We followed mice for 7- and 30-days and assessed their optokinetic response; retinal ganglion cell loss; axonal degeneration; glial reactivity; and retinal ER stress protein levels. O\n                  <jats:sub>2<\/jats:sub>\n                  reduced adolescent mortality by 40%, improved post-injury visual acuity, and reduced axonal degeneration and gliosis in optic projection regions. ER stress protein expression was altered in injured mice, and mice given O\n                  <jats:sub>2<\/jats:sub>\n                  utilized different ER-stress pathways in a time dependent manner. Finally, O\n                  <jats:sub>2<\/jats:sub>\n                  exposure may be mediating these ER stress responses through regulation of the redox-sensitive ER folding protein ERO1\u03b1, which has been linked to a reduction in the toxic effects of free radicals in other animal models of ER stress.\n                <\/jats:p>","DOI":"10.1101\/2023.05.09.540060","type":"posted-content","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T13:33:10Z","timestamp":1683725590000},"source":"Crossref","is-referenced-by-count":0,"title":["Brief oxygen exposure after traumatic brain injury speeds recovery and promotes adaptive chronic endoplasmic reticulum stress responses"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3502-0680","authenticated-orcid":false,"given":"Jordyn N.","family":"Torrens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6497-378X","authenticated-orcid":false,"given":"Shelby M.","family":"Hetzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-9764","authenticated-orcid":false,"given":"Nathan K.","family":"Evanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"issue":"4","key":"2023051103450738000_2023.05.09.540060v1.1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1089\/neu.1995.12.579","article-title":"The effect of associated injuries, blood loss, and oxygen debt on death and disability in blunt traumatic brain injury: the need for early physiologic predictors of severity","volume":"12","year":"1995","journal-title":"J Neurotrauma"},{"key":"2023051103450738000_2023.05.09.540060v1.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000037876.37236.D6"},{"key":"2023051103450738000_2023.05.09.540060v1.3","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318192fbd7"},{"issue":"5","key":"2023051103450738000_2023.05.09.540060v1.4","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1227\/NEU.0b013e3182287ca7","article-title":"Brain hypoxia is associated with short-term outcome after severe traumatic brain injury independently of intracranial hypertension and low cerebral perfusion pressure","volume":"69","year":"2011","journal-title":"Neurosurgery"},{"key":"2023051103450738000_2023.05.09.540060v1.5","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-973756"},{"issue":"4","key":"2023051103450738000_2023.05.09.540060v1.6","first-page":"281","article-title":"Brain tissue oxygen monitoring in pediatric patients with severe traumatic brain injury","volume":"105","year":"2006","journal-title":"Journal of Neurosurgery: Pediatrics PED"},{"issue":"6","key":"2023051103450738000_2023.05.09.540060v1.7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1159\/000121057","article-title":"The Prognostic Value of the Glasgow Coma Scale, Hypoxia and Computerised Tomography in Outcome Prediction of Pediatric Head Injury","volume":"24","year":"1996","journal-title":"Pediatric Neurosurgery"},{"key":"2023051103450738000_2023.05.09.540060v1.8","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31823f435c"},{"issue":"1","key":"2023051103450738000_2023.05.09.540060v1.9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/jcbfm.2012.130","article-title":"Alterations in cerebral oxygen metabolism after traumatic brain injury in children","volume":"33","year":"2013","journal-title":"Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"9","key":"2023051103450738000_2023.05.09.540060v1.10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1177\/0885066620944097","article-title":"Arterial Oxygenation in Traumatic Brain Injury-Relation to Cerebral Energy Metabolism, Autoregulation, and Clinical Outcome","volume":"36","year":"2021","journal-title":"Journal of intensive care medicine"},{"issue":"1","key":"2023051103450738000_2023.05.09.540060v1.11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/PCC.0000000000000001","article-title":"Age-specific cerebral perfusion pressure thresholds*","volume":"15","year":"2014","journal-title":"Pediatr Crit Care Med"},{"issue":"2","key":"2023051103450738000_2023.05.09.540060v1.12","first-page":"239","article-title":"Invasive brain tissue oxygen and intracranial pressure (ICP) monitoring versus ICP-only monitoring in pediatric severe traumatic brain injury","volume":"30","year":"2022","journal-title":"Journal of Neurosurgery: Pediatrics"},{"issue":"10","key":"2023051103450738000_2023.05.09.540060v1.13","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00381-009-0821-y","article-title":"Brain tissue oxygen tension monitoring in pediatric severe traumatic brain injury. 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