{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:11:54Z","timestamp":1785431514936,"version":"3.56.0"},"posted":{"date-parts":[[2023,5,14]]},"group-title":"Neuroscience","reference-count":135,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,8,19]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>Sexual stimulation triggers changes in female physiology and behavior, including sexual satiety and preparing the uterus for pregnancy. Serotonin is an important regulator of reproductive physiology and sexual receptivity, but the relationship between sexual stimulation and serotonin neural activity in females is poorly understood. Here, we investigated dorsal raphe serotonin neural activity in females during sexual behavior. We found that serotonin neural activity in mating females peaked specifically upon male ejaculation, and remained elevated above baseline until disengagement. Artificial intravaginal mechanical stimulation was sufficient to elicit increased 5-HT neural activity but the delivery of ejaculatory fluids was not. Distal penis erectile enlargement (\u201cpenile cupping\u201d) at ejaculation and forceful expulsion of ejaculatory fluid each provided sufficient mechanical stimulation to elicit serotonin neuron activation. Our study identifies a female ejaculation-specific signal in a major neuromodulatory system and shows that intravaginal mechanosensory stimulation is necessary and sufficient to drive this signal.<\/jats:p>","DOI":"10.1101\/2023.05.14.540716","type":"posted-content","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T12:03:36Z","timestamp":1684152216000},"source":"Crossref","is-referenced-by-count":1,"title":["Serotonin neurons in mating female mice are activated by male ejaculation"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-1290","authenticated-orcid":false,"given":"Eileen L.","family":"Troconis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3903-7452","authenticated-orcid":false,"given":"Changwoo","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1915-3165","authenticated-orcid":false,"given":"Akash","family":"Guru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2240-3997","authenticated-orcid":false,"given":"Melissa R.","family":"Warden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2023082208350602000_2023.05.14.540716v2.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1986.tb27995.x"},{"key":"2023082208350602000_2023.05.14.540716v2.2","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1016\/j.cub.2019.10.012","article-title":"Coordinated Behavioral and Physiological Responses to a Social Signal Are Regulated by a Shared Neuronal Circuit","volume":"29","year":"2019","journal-title":"Current Biology"},{"key":"2023082208350602000_2023.05.14.540716v2.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2016.01.004"},{"key":"2023082208350602000_2023.05.14.540716v2.4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ento-120709-144823"},{"key":"2023082208350602000_2023.05.14.540716v2.5","doi-asserted-by":"publisher","DOI":"10.1006\/frne.2000.0198"},{"key":"2023082208350602000_2023.05.14.540716v2.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.041"},{"key":"2023082208350602000_2023.05.14.540716v2.7","first-page":"1","article-title":"Characteristics of masculine sex drive","volume":"4","year":"1956","journal-title":"Nebraska Symposium on Motivation"},{"key":"2023082208350602000_2023.05.14.540716v2.8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1152\/jn.1988.59.1.142","article-title":"Afferent fibers supplying the uterus in the rat","volume":"59","year":"1988","journal-title":"Journal of Neurophysiology"},{"key":"2023082208350602000_2023.05.14.540716v2.9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1152\/jn.1990.63.2.256","article-title":"Functional properties of afferent fibers supplying reproductive and other pelvic organs in pelvic nerve of female rat","volume":"63","year":"1990","journal-title":"Journal of Neurophysiology"},{"key":"2023082208350602000_2023.05.14.540716v2.10","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.2.533"},{"key":"2023082208350602000_2023.05.14.540716v2.11","doi-asserted-by":"publisher","DOI":"10.1126\/science.133.3466.1771"},{"key":"2023082208350602000_2023.05.14.540716v2.12","doi-asserted-by":"publisher","DOI":"10.1037\/h0023152"},{"key":"2023082208350602000_2023.05.14.540716v2.13","doi-asserted-by":"publisher","DOI":"10.1038\/184105a0"},{"key":"2023082208350602000_2023.05.14.540716v2.14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.brainres.2004.07.022","article-title":"Medullary noradrenergic neurons release norepinephrine in the medial amygdala in females in response to mating stimulation sufficient for pseudopregnancy","volume":"1022","year":"2004","journal-title":"Brain Research"},{"key":"2023082208350602000_2023.05.14.540716v2.15","doi-asserted-by":"publisher","DOI":"10.1210\/endo-77-6-1014"},{"key":"2023082208350602000_2023.05.14.540716v2.16","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.cub.2020.09.090","article-title":"Phasic activation of dorsal raphe serotonergic neurons increases pupil size","volume":"31","year":"2021","journal-title":"Current Biology"},{"key":"2023082208350602000_2023.05.14.540716v2.17","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90192-4"},{"key":"2023082208350602000_2023.05.14.540716v2.18","doi-asserted-by":"publisher","DOI":"10.1038\/nature12354"},{"key":"2023082208350602000_2023.05.14.540716v2.19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094987"},{"key":"2023082208350602000_2023.05.14.540716v2.20","doi-asserted-by":"publisher","DOI":"10.1038\/nature13131"},{"key":"2023082208350602000_2023.05.14.540716v2.21","doi-asserted-by":"crossref","unstructured":"Cohen, J.Y. , Amoroso, M.W. , Uchida, N . Serotonergic neurons signal reward and punishment on multiple timescales. eLife 4, 06346.","DOI":"10.7554\/eLife.06346"},{"key":"2023082208350602000_2023.05.14.540716v2.22","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod23.1.111"},{"key":"2023082208350602000_2023.05.14.540716v2.23","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1999.0705"},{"key":"2023082208350602000_2023.05.14.540716v2.24","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193270"},{"key":"2023082208350602000_2023.05.14.540716v2.25","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90021-M"},{"key":"2023082208350602000_2023.05.14.540716v2.26","first-page":"222446","article-title":"Responses and functions of dopamine in nucleus accumbens core during social behaviors","volume":"40","year":"2022","journal-title":"Cell Reports"},{"key":"2023082208350602000_2023.05.14.540716v2.27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1152\/ajprenal.00214.2019","article-title":"Expression and distribution of PIEZO1 in the mouse urinary tract","volume":"317","year":"2019","journal-title":"American Journal of Physiology-Renal Physiology"},{"key":"2023082208350602000_2023.05.14.540716v2.28","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1371\/journal.pcbi.0040004","article-title":"Serotonin, inhibition, and negative mood","volume":"4","year":"2008","journal-title":"PLoS Computational Biology"},{"key":"2023082208350602000_2023.05.14.540716v2.29","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135607"},{"key":"2023082208350602000_2023.05.14.540716v2.30","doi-asserted-by":"publisher","DOI":"10.1177\/026988119100500414"},{"key":"2023082208350602000_2023.05.14.540716v2.31","doi-asserted-by":"crossref","first-page":"1003185","DOI":"10.1371\/journal.pgen.1003185","article-title":"Genetic disruption of the copulatory plug in mice leads to severely reduced fertility","volume":"9","year":"2013","journal-title":"PLoS Genetics"},{"key":"2023082208350602000_2023.05.14.540716v2.32","doi-asserted-by":"publisher","DOI":"10.1038\/nature12518"},{"key":"2023082208350602000_2023.05.14.540716v2.33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105941"},{"key":"2023082208350602000_2023.05.14.540716v2.34","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(72)90354-X"},{"key":"2023082208350602000_2023.05.14.540716v2.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.12.009"},{"key":"2023082208350602000_2023.05.14.540716v2.36","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(88)90355-1"},{"key":"2023082208350602000_2023.05.14.540716v2.37","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.99.1.151"},{"key":"2023082208350602000_2023.05.14.540716v2.38","first-page":"690","article-title":"Pelvic and pudendal nerves influence the display of paced mating behavior in response to estrogen and progesterone in the female rat","volume":"4","year":"1992","journal-title":"Behavioral Neuroscience"},{"key":"2023082208350602000_2023.05.14.540716v2.39","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-16-4-508"},{"key":"2023082208350602000_2023.05.14.540716v2.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.01.026"},{"key":"2023082208350602000_2023.05.14.540716v2.41","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1331.2001.00764.x"},{"key":"2023082208350602000_2023.05.14.540716v2.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.12.002"},{"key":"2023082208350602000_2023.05.14.540716v2.43","doi-asserted-by":"publisher","DOI":"10.1159\/000127277"},{"key":"2023082208350602000_2023.05.14.540716v2.44","doi-asserted-by":"publisher","DOI":"10.1038\/1761209a0"},{"key":"2023082208350602000_2023.05.14.540716v2.45","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-39-10204"},{"key":"2023082208350602000_2023.05.14.540716v2.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.017"},{"key":"2023082208350602000_2023.05.14.540716v2.47","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-4-1-44"},{"key":"2023082208350602000_2023.05.14.540716v2.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2016.01.006"},{"key":"2023082208350602000_2023.05.14.540716v2.49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401337101"},{"key":"2023082208350602000_2023.05.14.540716v2.50","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/0031-9384(73)90291-6","article-title":"The role of reinforcement in the sexual behavior of the female rat","volume":"11","year":"1973","journal-title":"Physiology & Behavior"},{"key":"2023082208350602000_2023.05.14.540716v2.51","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01121-8"},{"key":"2023082208350602000_2023.05.14.540716v2.52","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-1047(86)80010-3"},{"key":"2023082208350602000_2023.05.14.540716v2.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.025"},{"key":"2023082208350602000_2023.05.14.540716v2.54","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neuron.2017.05.038","article-title":"A labeled-line neural circuit for pheromone-mediated sexual behaviors in mice","volume":"95","year":"2017","journal-title":"Neuron"},{"key":"2023082208350602000_2023.05.14.540716v2.55","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0015-0282(16)41962-X","article-title":"Postcoital luteinizing hormone release in male and female rabbits as determind by radioimmunoassay","volume":"27","year":"1976","journal-title":"Fertility and Sterility"},{"key":"2023082208350602000_2023.05.14.540716v2.56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320715111"},{"key":"2023082208350602000_2023.05.14.540716v2.57","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/ar.1091150406","article-title":"Reproduction in the female rat after pelvic nerve neurectomy","volume":"115","year":"1953","journal-title":"The Anatomical Record"},{"key":"2023082208350602000_2023.05.14.540716v2.58","doi-asserted-by":"publisher","DOI":"10.1210\/endo-93-3-548"},{"key":"2023082208350602000_2023.05.14.540716v2.59","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01312-1"},{"key":"2023082208350602000_2023.05.14.540716v2.60","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.celrep.2019.04.096","article-title":"An atlas of vagal sensory neurons and their molecular specialization","volume":"27","year":"2019","journal-title":"Cell Reports"},{"key":"2023082208350602000_2023.05.14.540716v2.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2003.09.011"},{"key":"2023082208350602000_2023.05.14.540716v2.62","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.conb.2019.12.001","article-title":"In the mood for sex: neural circuits for reproduction","volume":"60","year":"2020","journal-title":"Current Opinion in Neurobiology"},{"key":"2023082208350602000_2023.05.14.540716v2.63","doi-asserted-by":"crossref","first-page":"10503","DOI":"10.1038\/ncomms10503","article-title":"Serotonin neurons in the dorsal raphe nucleus encode reward signals","volume":"7","year":"2016","journal-title":"Nature Communications"},{"key":"2023082208350602000_2023.05.14.540716v2.64","doi-asserted-by":"crossref","unstructured":"Lorenz, K . (1981). The foundations of ethology. Springer verlag.","DOI":"10.1007\/978-3-7091-3671-3"},{"key":"2023082208350602000_2023.05.14.540716v2.65","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.mayocp.2016.04.033","article-title":"Antidepressant-induced female sexual dysfunction","volume":"91","year":"2016","journal-title":"Mayo Clinic Proceedings"},{"key":"2023082208350602000_2023.05.14.540716v2.66","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1007\/s12264-022-00908-8","article-title":"Serotonin signaling modulates sexual receptivity of virgin female Drosophila","volume":"38","year":"2022","journal-title":"Neuroscience Bulletin"},{"key":"2023082208350602000_2023.05.14.540716v2.67","doi-asserted-by":"publisher","DOI":"10.1038\/nature19318"},{"key":"2023082208350602000_2023.05.14.540716v2.68","unstructured":"Masters, W.H. , and Johnson, V.E . (1966). Human sexual response. Little, Brown."},{"key":"2023082208350602000_2023.05.14.540716v2.69","doi-asserted-by":"crossref","first-page":"20552","DOI":"10.7554\/eLife.20552","article-title":"Activity patterns of serotonin neurons underlying cognitive flexibility","volume":"6","year":"2017","journal-title":"eLife"},{"key":"2023082208350602000_2023.05.14.540716v2.70","doi-asserted-by":"publisher","DOI":"10.1037\/h0077364"},{"key":"2023082208350602000_2023.05.14.540716v2.71","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00040-2"},{"key":"2023082208350602000_2023.05.14.540716v2.72","doi-asserted-by":"publisher","DOI":"10.1163\/156853978X00260"},{"key":"2023082208350602000_2023.05.14.540716v2.73","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1037\/h0077872","article-title":"Postejaculatory quiescence in female and male rats: consequences for sperm transport during group mating","volume":"96","year":"1982","journal-title":"Journal of Comparative and Physiological Psychology"},{"key":"2023082208350602000_2023.05.14.540716v2.74","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.celrep.2014.08.037","article-title":"Serotonergic and nonserotonergic dorsal raphe projection neurons: differential participation in reward circuitry","volume":"8","year":"2014","journal-title":"Cell Reports"},{"key":"2023082208350602000_2023.05.14.540716v2.75","doi-asserted-by":"publisher","DOI":"10.1016\/0018-506X(70)90015-2"},{"key":"2023082208350602000_2023.05.14.540716v2.76","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0210215"},{"key":"2023082208350602000_2023.05.14.540716v2.77","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0150149"},{"key":"2023082208350602000_2023.05.14.540716v2.78","doi-asserted-by":"publisher","DOI":"10.1016\/0163-1047(93)90257-I"},{"key":"2023082208350602000_2023.05.14.540716v2.79","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-10-03016.1987"},{"key":"2023082208350602000_2023.05.14.540716v2.80","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.yhbeh.2008.09.003","article-title":"Artificial vaginocervial stimulation induces a conditioned place preference in female rats","volume":"55","year":"2009","journal-title":"Hormones and Behavior"},{"key":"2023082208350602000_2023.05.14.540716v2.81","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.117.1.144"},{"key":"2023082208350602000_2023.05.14.540716v2.82","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8232-6"},{"key":"2023082208350602000_2023.05.14.540716v2.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.07.041"},{"key":"2023082208350602000_2023.05.14.540716v2.84","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00429-014-0924-4","article-title":"Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5\u2013B9) to the forebrain and brainstem","volume":"221","year":"2016","journal-title":"Brain Structure and Function"},{"key":"2023082208350602000_2023.05.14.540716v2.85","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0031-9384(77)90293-1","article-title":"Facilitation of tonic immobility by stimulation of the vaginal cervix in the rat","volume":"19","year":"1977","journal-title":"Physiology & Behavior"},{"key":"2023082208350602000_2023.05.14.540716v2.86","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0021-08.2008"},{"key":"2023082208350602000_2023.05.14.540716v2.87","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(90)90221-K"},{"key":"2023082208350602000_2023.05.14.540716v2.88","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07049-5"},{"key":"2023082208350602000_2023.05.14.540716v2.89","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/j.neuron.2022.05.015","article-title":"Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors","volume":"110","year":"2022","journal-title":"Neuron"},{"key":"2023082208350602000_2023.05.14.540716v2.90","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2009.05.008"},{"key":"2023082208350602000_2023.05.14.540716v2.91","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1037\/0735-7044.111.1.123","article-title":"Sexual behavior regulated (paced) by the female induces conditioned place preference","volume":"111","year":"1997","journal-title":"Behavioral Neuroscience"},{"key":"2023082208350602000_2023.05.14.540716v2.92","doi-asserted-by":"publisher","DOI":"10.1037\/h0040740"},{"key":"2023082208350602000_2023.05.14.540716v2.93","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90372-6"},{"key":"2023082208350602000_2023.05.14.540716v2.94","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2335"},{"key":"2023082208350602000_2023.05.14.540716v2.95","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199008000-00008"},{"key":"2023082208350602000_2023.05.14.540716v2.96","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.020"},{"key":"2023082208350602000_2023.05.14.540716v2.97","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-578"},{"key":"2023082208350602000_2023.05.14.540716v2.98","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0897.2011.01033.x","article-title":"Seminal plasma proteins: What role do they play?","volume":"66","year":"2011","journal-title":"American Journal of Reproductive Immunology"},{"key":"2023082208350602000_2023.05.14.540716v2.99","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90294-W"},{"key":"2023082208350602000_2023.05.14.540716v2.100","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(80)90242-5"},{"key":"2023082208350602000_2023.05.14.540716v2.101","first-page":"425","article-title":"Evidence for the involvement of serotonergic system in the male-induced ova-implantation failure (Bruce effect) in mice","volume":"41","year":"1980","journal-title":"Annales D\u2019Endocrinologie (Paris"},{"key":"2023082208350602000_2023.05.14.540716v2.102","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/mrd.22689","article-title":"The molecular basis and reproductive function(s) of copulatory plugs","volume":"83","year":"2016","journal-title":"Molecular Reproduction and Development"},{"key":"2023082208350602000_2023.05.14.540716v2.103","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau8722"},{"key":"2023082208350602000_2023.05.14.540716v2.104","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.neuron.2019.04.009","article-title":"A neural circuit encoding the experience of copulation in female Drosophila","volume":"102","year":"2019","journal-title":"Neuron"},{"key":"2023082208350602000_2023.05.14.540716v2.105","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6773(76)91486-3"},{"key":"2023082208350602000_2023.05.14.540716v2.106","doi-asserted-by":"publisher","DOI":"10.1210\/endo-98-6-1370"},{"key":"2023082208350602000_2023.05.14.540716v2.107","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X00022871"},{"key":"2023082208350602000_2023.05.14.540716v2.108","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.04.016"},{"key":"2023082208350602000_2023.05.14.540716v2.109","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90418-9"},{"key":"2023082208350602000_2023.05.14.540716v2.110","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.celrep.2015.10.061","article-title":"Activity of raph\u00e9 serotonergic neurons controls emotional behaviors","volume":"13","year":"2015","journal-title":"Cell Reports"},{"key":"2023082208350602000_2023.05.14.540716v2.111","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.dcn.2011.05.007","article-title":"Evaluating the rewarding nature of social interactions in laboratory animals","volume":"1","year":"2011","journal-title":"Developmental Cognitive Neuroscience"},{"key":"2023082208350602000_2023.05.14.540716v2.112","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pbb.2013.11.008","article-title":"Pharmacology of serotonin and female sexual behavior","volume":"121","year":"2014","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"2023082208350602000_2023.05.14.540716v2.113","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0028-3908(92)90097-9","article-title":"Intracerebral actions of the 5-HT1A agonists, 8-OH-DPAT and buspirone and of the 5-HT1A partial agonist\/antagonist, NAN-190, on female sexual behavior","volume":"31","year":"1992","journal-title":"Neuropharmacology"},{"key":"2023082208350602000_2023.05.14.540716v2.114","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(93)90077-G"},{"key":"2023082208350602000_2023.05.14.540716v2.115","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00196-4"},{"key":"2023082208350602000_2023.05.14.540716v2.116","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.brainres.2005.12.033","article-title":"Fluoxetine disrupts food intake and estrous cyclicity in Fischer female rats","volume":"1072","year":"2006","journal-title":"Brain Research"},{"key":"2023082208350602000_2023.05.14.540716v2.117","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3881"},{"key":"2023082208350602000_2023.05.14.540716v2.118","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903130409"},{"key":"2023082208350602000_2023.05.14.540716v2.119","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41586-020-2055-9","article-title":"Neural circuitry linking mating and egg laying in Drosophila females","volume":"579","year":"2020","journal-title":"Nature"},{"key":"2023082208350602000_2023.05.14.540716v2.120","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.neuron.2021.02.012","article-title":"Neural circuits of social behaviors: innate yet flexible","volume":"109","year":"2021","journal-title":"Neuron"},{"key":"2023082208350602000_2023.05.14.540716v2.121","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01082-2"},{"key":"2023082208350602000_2023.05.14.540716v2.122","doi-asserted-by":"publisher","DOI":"10.1210\/en.131.5.2045"},{"key":"2023082208350602000_2023.05.14.540716v2.123","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0031-9384(97)00523-4","article-title":"Influence of male-related stimuli on female postejaculatory refractory period in rats","volume":"63","year":"1998","journal-title":"Physiology & Behavior"},{"key":"2023082208350602000_2023.05.14.540716v2.124","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01803.x"},{"key":"2023082208350602000_2023.05.14.540716v2.125","doi-asserted-by":"publisher","DOI":"10.1038\/nature06483"},{"key":"2023082208350602000_2023.05.14.540716v2.126","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1016\/j.neuron.2022.06.026","article-title":"VMHvllCckar cells dynamically control female sexual behaviors over the reproductive cycle","volume":"110","year":"2022","journal-title":"Neuron"},{"key":"2023082208350602000_2023.05.14.540716v2.127","doi-asserted-by":"crossref","first-page":"105339","DOI":"10.1016\/j.yhbeh.2023.105339","article-title":"Neural control of female sexual behaviors","volume":"151","year":"2023","journal-title":"Hormones and Behavior"},{"key":"2023082208350602000_2023.05.14.540716v2.128","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220712110"},{"key":"2023082208350602000_2023.05.14.540716v2.129","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2004.09.020"},{"key":"2023082208350602000_2023.05.14.540716v2.130","doi-asserted-by":"publisher","DOI":"10.1177\/0192623315570339"},{"key":"2023082208350602000_2023.05.14.540716v2.131","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msp094"},{"key":"2023082208350602000_2023.05.14.540716v2.132","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-1"},{"key":"2023082208350602000_2023.05.14.540716v2.133","doi-asserted-by":"publisher","DOI":"10.1016\/0018-506X(70)90015-2"},{"key":"2023082208350602000_2023.05.14.540716v2.134","first-page":"e63720","article-title":"The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice","volume":"10","year":"2020","journal-title":"eLife"},{"key":"2023082208350602000_2023.05.14.540716v2.135","doi-asserted-by":"crossref","unstructured":"Souza, V.R. , Mendes, E. , Casaro, M. , Antiorio, A.T.F. , Oliveira, F.A. , and Ferreira, C.M . (2019). Description of ovariectomy protocol in mice. In Pre-Clinical Models (pp. 303-309). Humana Press.","DOI":"10.1007\/978-1-4939-8994-2_29"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2023.05.14.540716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:39:44Z","timestamp":1768451984000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2023.05.14.540716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,14]]},"references-count":135,"URL":"https:\/\/doi.org\/10.1101\/2023.05.14.540716","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1016\/j.cub.2023.09.071","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2023,5,14]]},"subtype":"preprint"}}