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For a model for inflammation elicited by various pathogens, the endotoxin lipopolysaccharide (LPS) was used to compare genome-wide transcription in blood by\n                  <jats:italic>P. leucopus<\/jats:italic>\n                  ,\n                  <jats:italic>Mus musculus<\/jats:italic>\n                  and\n                  <jats:italic>Rattus norvegicus<\/jats:italic>\n                  and adjusted for white cell concentrations. Deermice were distinguished from the mice and rats by LPS response profiles consistent with non-classical monocytes and alternatively-activated macrophages. LPS-treated\n                  <jats:italic>P. leucopus<\/jats:italic>\n                  , in contrast to mice and rats, also displayed little transcription of interferon-gamma and lower magnitude fold-changes in type 1 interferon-stimulated genes. This was associated with comparatively reduced transcription of endogenous retrovirus sequences and cytoplasmic pattern recognition receptors in the deermice. The results reveal a mechanism for infection tolerance in this species and perhaps other animal reservoirs for agents of human disease.\n                <\/jats:p>","DOI":"10.1101\/2023.06.06.543964","type":"posted-content","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T10:15:29Z","timestamp":1686132929000},"source":"Crossref","is-referenced-by-count":1,"title":["The white-footed deermouse, an infection-tolerant reservoir for several zoonotic agents, tempers interferon responses to endotoxin in comparison to the mouse and rat"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6218-0452","authenticated-orcid":false,"given":"Ana","family":"Milovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan V.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-5248","authenticated-orcid":false,"given":"Alan G.","family":"Barbour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023101709150594000_2023.06.06.543964v3.1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119038109"},{"key":"2023101709150594000_2023.06.06.543964v3.2","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"2023101709150594000_2023.06.06.543964v3.3","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00588-21"},{"key":"2023101709150594000_2023.06.06.543964v3.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.07.002"},{"key":"2023101709150594000_2023.06.06.543964v3.5","unstructured":"Barbour AG . 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