{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:48:49Z","timestamp":1768506529568,"version":"3.49.0"},"posted":{"date-parts":[[2023,6,9]]},"group-title":"Genomics","reference-count":60,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Meiotic recombination is crucial for human genetic diversity and chromosome segregation accuracy. Understanding its variation across individuals and the processes by which it goes awry are long-standing goals in human genetics. Current approaches for inferring recombination landscapes either rely on population genetic patterns of linkage disequilibrium (LD)\u2014capturing a time-averaged view\u2014or direct detection of crossovers in gametes or multi-generation pedigrees, which limits dataset scale and availability. Here, we introduce an approach for inferring sex-specific recombination landscapes using data from preimplantation genetic testing for aneuploidy (PGT-A). This method relies on low-coverage (&lt;0.05\n                  <jats:italic>\u00d7<\/jats:italic>\n                  ) whole-genome sequencing of\n                  <jats:italic>in vitro<\/jats:italic>\n                  fertilized (IVF) embryo biopsies. To overcome the data sparsity, our method exploits its inherent relatedness structure, knowledge of haplotypes from external population reference panels, as well as the frequent occurrence of monosomies in embryos, whereby the remaining chromosome is phased by default. Extensive simulations demonstrate our method\u2019s high accuracy, even at coverages as low as 0.02\n                  <jats:italic>\u00d7<\/jats:italic>\n                  . Applying this method to PGT-A data from 18,967 embryos, we mapped 70,660 recombination events with\n                  <jats:italic>\u223c<\/jats:italic>\n                  150 kbp resolution, replicating established sex-specific recombination patterns. We observed a reduced total length of the female genetic map in trisomies compared to disomies, as well as chromosome-specific alterations in crossover distributions. Based on haplotype configurations in pericentromeric regions, our data indicate chromosome-specific propensities for different mechanisms of meiotic error. Our results provide a comprehensive view of the role of aberrant meiotic recombination in the origins of human aneuploidies and offer a versatile tool for mapping crossovers in low-coverage sequencing data from multiple siblings.\n                <\/jats:p>","DOI":"10.1101\/2023.06.07.543910","type":"posted-content","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T21:00:16Z","timestamp":1686344416000},"source":"Crossref","is-referenced-by-count":3,"title":["Aberrant landscapes of maternal meiotic crossovers contribute to aneuploidies in human 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