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IL-10 upregulated expression and analgesic activity of \u03b4-opioid receptor (\u03b4OR) in the dorsal root ganglion. Genetic or pharmacological inhibition of IL-10 signaling or \u03b4OR triggered relapse to pain in both sexes. These data challenge the widespread assumption that remission of pain is simply a return to the na\u00efve state before pain was induced. Instead, our findings strongly suggest a novel concept that: remission is a state of lasting pain vulnerability that results from a long-lasting neuroimmune interactions in the nociceptive system.<\/jats:p>","DOI":"10.1101\/2023.06.08.544200","type":"posted-content","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T22:40:11Z","timestamp":1686350411000},"source":"Crossref","is-referenced-by-count":2,"title":["Tonic Meningeal Interleukin-10 Upregulates Delta Opioid Receptor to Prevent Relapse to Pain"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0735-6945","authenticated-orcid":false,"given":"Kufreobong E.","family":"Inyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4560-3525","authenticated-orcid":false,"given":"Jaewon","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly 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