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Our results show that vitamin D deficiency is associated with changes in the metabolic networks of tryptophan, linoleic, and fatty acid metabolism. These changes correlate with distinct ASD-related phenotypes, including delayed communication skills and respiratory dysfunctions. Additionally, our analysis suggests the kynurenine and serotonin sub-pathways may mediate the effect of vitamin D on early childhood communication development. Altogether, our findings provide metabolome-wide insights into the potential of vitamin D as a therapeutic option for ASD and other communication disorders.<\/jats:p>","DOI":"10.1101\/2023.06.23.546277","type":"posted-content","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T18:05:13Z","timestamp":1687802713000},"source":"Crossref","is-referenced-by-count":2,"title":["The metabolic role of vitamin D in children\u2019s neurodevelopment: a network study"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1821-208X","authenticated-orcid":false,"given":"Margherita De","family":"Marzio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Lasky-Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su H.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Prince","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto A.","family":"Litonjua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7196-303X","authenticated-orcid":false,"given":"Scott T.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel S.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly R.","family":"Glass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023071910151062000_2023.06.23.546277v2.1","unstructured":"Data, C. statistics on autism spectrum disorder| CDC. 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