{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T15:42:28Z","timestamp":1780933348248,"version":"3.54.1"},"posted":{"date-parts":[[2023,7,3]]},"group-title":"Neuroscience","reference-count":19,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Adipocyte-derived leptin enters the brain to exert its anorexigenic action, yet its transport mechanism is poorly understood. Here we report that LRP1 (low-density lipoprotein receptor-related protein-1) mediates the transport of leptin across the blood-CSF barrier in\n                  <jats:italic>Foxj1<\/jats:italic>\n                  expressing cells highly enriched at the choroid plexus (ChP), coupled with the short-form leptin receptor, and LRP1 deletion from ependymocytes and ChP cells leads to leptin resistance and hyperphagia, causing obesity. Thus, LRP1 in epithelial cells is a principal regulator of leptin transport in the brain.\n                <\/jats:p>","DOI":"10.1101\/2023.07.03.547520","type":"posted-content","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T20:00:35Z","timestamp":1688414435000},"source":"Crossref","is-referenced-by-count":2,"title":["LRP1 mediates leptin transport by coupling with the short-form leptin receptor in the choroid plexus"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9242-8279","authenticated-orcid":false,"given":"Aaron Aykut","family":"Uner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Mo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Cheol","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellen Cristina da Cruz","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Aydogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji A","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia F.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Seon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Ezzahra","family":"Timzoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lehtinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Prevot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9471-6330","authenticated-orcid":false,"given":"Young-Bum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2023070713050858000_2023.07.03.547520v1.1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.62.1.413"},{"key":"2023070713050858000_2023.07.03.547520v1.2","doi-asserted-by":"crossref","unstructured":"Ahima, R. S. , Saper, C. B. , Flier, J. S. , and Elmquist, J. K. Leptin regulation of neuroendocrine systems. 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