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We use tactile stimulation and electrical activation of parallel fibers to probe intrinsic and synaptic contributions to receptive field (RF) plasticity in awake mice during two-photon calcium imaging of cerebellar Purkinje cells. Repetitive activation of both stimuli induced response potentiation that is impaired in mice with selective deficits in either intrinsic plasticity (SK2 KO) or LTP (CaMKII TT305\/6VA). Intrinsic, but not synaptic, plasticity expands the local, dendritic RF representation. Simultaneous dendrite and axon initial segment recordings confirm that these dendritic events affect axonal output. Our findings support the hypothesis that intrinsic plasticity provides an amplification mechanism that exerts a permissive control over the impact of LTP on neuronal responsiveness.<\/jats:p>","DOI":"10.1101\/2023.07.19.549760","type":"posted-content","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T17:40:10Z","timestamp":1689961210000},"source":"Crossref","is-referenced-by-count":1,"title":["Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0261-8309","authenticated-orcid":false,"given":"Ting-Feng","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-1921","authenticated-orcid":false,"given":"Silas E.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-7097","authenticated-orcid":false,"given":"Christian","family":"Hansel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023082308301962000_2023.07.19.549760v2.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000596"},{"key":"2023082308301962000_2023.07.19.549760v2.2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3226-10.2010"},{"key":"2023082308301962000_2023.07.19.549760v2.3","doi-asserted-by":"crossref","unstructured":"Gill DF , Hansel C . 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