{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:00:19Z","timestamp":1768507219163,"version":"3.49.0"},"posted":{"date-parts":[[2023,7,26]]},"group-title":"Neuroscience","reference-count":82,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>A preclinical model of cue exposure therapy, cue extinction, reduces cue-induced cocaine seeking when drug seeking is goal-directed but not habitual. Goal-directed and habitual behaviors differentially rely on the dorsomedial striatum (DMS) and dorsolateral striatum (DLS), but the effects of cue extinction on dorsal striatal responses to cue-induced drug seeking are unknown. We used fiber photometry to examine how dorsal striatal intracellular calcium and extracellular dopamine activity differs between goal-directed and habitual cue-induced cocaine seeking and how it is impacted by cue extinction. Rats trained to self-administer cocaine paired with an audiovisual cue on schedules of reinforcement that promote goal-directed or habitual cocaine seeking had different patterns of dorsal striatal calcium and dopamine responses to cue-reinforced lever presses. Cue extinction reduced calcium and dopamine responses during subsequent drug seeking in the DMS, but not in the DLS. Therefore, cue extinction may reduce goal-directed behavior through its effects on the DMS, whereas habitual behavior and the DLS are unaffected.<\/jats:p>","DOI":"10.1101\/2023.07.24.550364","type":"posted-content","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T19:55:12Z","timestamp":1690401312000},"source":"Crossref","is-referenced-by-count":1,"title":["Changes in dorsomedial striatum activity mediate expression of goal-directed vs. habit-like cue-induced cocaine seeking"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3296-6144","authenticated-orcid":false,"given":"Brooke N.","family":"Bender","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4840-0866","authenticated-orcid":false,"given":"Sierra J.","family":"Stringfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-0231","authenticated-orcid":false,"given":"Mary M.","family":"Torregrossa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023072812301341000_2023.07.24.550364v1.1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1999.9433273.x"},{"key":"2023072812301341000_2023.07.24.550364v1.2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.12040"},{"key":"2023072812301341000_2023.07.24.550364v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.01.002"},{"key":"2023072812301341000_2023.07.24.550364v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00619-5"},{"key":"2023072812301341000_2023.07.24.550364v1.5","doi-asserted-by":"crossref","first-page":"e186466","DOI":"10.1001\/jamanetworkopen.2018.6466","article-title":"Association of Neural Responses to Drug Cues With Subsequent Relapse to Stimulant Use","volume":"1","year":"2018","journal-title":"JAMA Netw. open"},{"key":"2023072812301341000_2023.07.24.550364v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.02.014"},{"key":"2023072812301341000_2023.07.24.550364v1.7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/adb.12534","article-title":"Methamphetamine promotes habitual action and alters the density of striatal glutamate receptor and vesicular proteins in dorsal striatum","volume":"23","year":"2018","journal-title":"Addict. 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