{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:06:24Z","timestamp":1768565184132,"version":"3.49.0"},"posted":{"date-parts":[[2023,8,15]]},"group-title":"Neurology","reference-count":33,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>\n                    Cerebral cavernous malformations (CCMs) are abnormal clusters of capillaries in the nervous system. This pilot study analyzed the cardiometabolic health status of individuals with familial CCMs caused by a rare mutation in the\n                    <jats:italic>CCM1<\/jats:italic>\n                    gene (fCCM1). The aim was to compare plasma water T\n                    <jats:sub>2<\/jats:sub>\n                    values from individuals with fCCM1 with values from metabolically unhealthy and healthy individuals with no known CCM mutations.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>\n                    This observational, cross-sectional study included 75 participants: 11 fCCM1 patients, 24 metabolically unhealthy and 40 metabolically healthy individuals. Plasma water T\n                    <jats:sub>2<\/jats:sub>\n                    , an early, global and practical marker of cardiometabolic health, was measured in the time domain using benchtop magnetic resonance relaxometry. The results were stratified by age (\u2264 45 vs. &gt;45 years). Group means were compared using Welch\u2019s one-way ANOVA and\n                    <jats:italic>post hoc<\/jats:italic>\n                    Tukey-Kramer tests. Multivariable linear regression, with T\n                    <jats:sub>2<\/jats:sub>\n                    as the outcome variable, was used to explore associations with age, gender, Hispanic ethnicity and fCCM1 status.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    In the younger age stratum, the fCCM1 group had a mean plasma water T\n                    <jats:sub>2<\/jats:sub>\n                    value comparable to the metabolically healthy group (p=0.6388), but higher than the unhealthy group (p&lt;0.0001). By contrast, in the older stratum, the mean plasma water T\n                    <jats:sub>2<\/jats:sub>\n                    value for the fCCM1 group was comparable to the metabolically\n                    <jats:italic>un<\/jats:italic>\n                    healthy group (p=0.7819) and lower than the healthy group (p=0.0005). Multivariable linear regression revealed that age and the\n                    <jats:italic>interaction<\/jats:italic>\n                    between age and fCCM1 status were significant predictors of T\n                    <jats:sub>2<\/jats:sub>\n                    , even after adjusting for gender and Hispanic ethnicity.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>\n                    Plasma water T\n                    <jats:sub>2<\/jats:sub>\n                    shows potential as a biomarker for assessing the health status of individuals with fCCM1. Further research is needed to validate these preliminary observations and elucidate the association between CCMs and cardiometabolic health.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2023.08.10.23293944","type":"posted-content","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T01:20:11Z","timestamp":1692148811000},"source":"Crossref","is-referenced-by-count":0,"title":["Plasma water T\n                  <sub>2<\/sub>\n                  detects age-stratified differences in cardiometabolic health among familial CCM patients with Hispanic CCM1 mutation"],"prefix":"10.64898","author":[{"given":"Jacob","family":"Croft","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana F.","family":"Sandoval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cistola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4379-3616","authenticated-orcid":false,"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023081814400424000_2023.08.10.23293944v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.177"},{"key":"2023081814400424000_2023.08.10.23293944v1.2","doi-asserted-by":"crossref","unstructured":"Zhang J : Molecular biology of cerebral cavernous malformation. 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