{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:15:29Z","timestamp":1768508129734,"version":"3.49.0"},"posted":{"date-parts":[[2023,8,14]]},"group-title":"Bioengineering","reference-count":83,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>There are a growing number of neuroimaging studies motivating joint structural and functional brain connectivity. Brain connectivity of different modalities provides insight into brain functional organization by leveraging complementary information, especially for brain disorders such as schizophrenia. In this paper, we propose a multi-modal independent component analysis (ICA) model that utilizes information from both structural and functional brain connectivity guided by spatial maps to estimate intrinsic connectivity networks (ICNs). Structural connectivity is estimated through whole-brain tractography on diffusion-weighted MRI (dMRI), while functional connectivity is derived from resting-state functional MRI (rs-fMRI). The proposed structural-functional connectivity and spatially constrained ICA (sfCICA) model estimates ICNs at the subject level using a multi-objective optimization framework. We evaluated our model using synthetic and real datasets (including dMRI and rs-fMRI from 149 schizophrenia patients and 162 controls). Multi-modal ICNs revealed enhanced functional coupling between ICNs with higher structural connectivity, improved modularity, and network distinction, particularly in schizophrenia. Statistical analysis of group differences showed more significant differences in the proposed model compared to the unimodal model. In summary, the sfCICA model showed benefits from being jointly informed by structural and functional connectivity. These findings suggest advantages in simultaneously learning effectively and enhancing connectivity estimates using structural connectivity.<\/jats:p>","DOI":"10.1101\/2023.08.13.553101","type":"posted-content","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T04:00:11Z","timestamp":1692072011000},"source":"Crossref","is-referenced-by-count":1,"title":["A spatially constrained independent component analysis jointly informed by structural and functional network connectivity"],"prefix":"10.64898","author":[{"given":"Mahshid","family":"Fouladivanda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Iraji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodorus G.M.","family":"van Erp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysenil","family":"Belger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faris","family":"Hawamdeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godfrey D.","family":"Pearlson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9058-0747","authenticated-orcid":false,"given":"Vince D.","family":"Calhoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024060408250451000_2023.08.13.553101v2.1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.9.1358"},{"key":"2024060408250451000_2023.08.13.553101v2.2","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00002"},{"key":"2024060408250451000_2023.08.13.553101v2.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200327197"},{"key":"2024060408250451000_2023.08.13.553101v2.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.019"},{"issue":"365","key":"2024060408250451000_2023.08.13.553101v2.5","first-page":"1","article-title":"Advanced normalization tools (ANTS)","volume":"2","year":"2009","journal-title":"Insight j"},{"key":"2024060408250451000_2023.08.13.553101v2.6","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.721206"},{"key":"2024060408250451000_2023.08.13.553101v2.7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903641106"},{"key":"2024060408250451000_2023.08.13.553101v2.8","doi-asserted-by":"publisher","DOI":"10.3390\/bs8040039"},{"issue":"2","key":"2024060408250451000_2023.08.13.553101v2.9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.31887\/DCNS.2018.20.2\/vcalhoun","article-title":"Data-driven approaches for identifying links between brain structure and function in health and disease","volume":"20","year":"2018","journal-title":"Dialogues in Clinical Neuroscience"},{"key":"2024060408250451000_2023.08.13.553101v2.10","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2012.2211076"},{"key":"2024060408250451000_2023.08.13.553101v2.11","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20204"},{"key":"2024060408250451000_2023.08.13.553101v2.12","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1048"},{"key":"2024060408250451000_2023.08.13.553101v2.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2017.06.012"},{"key":"2024060408250451000_2023.08.13.553101v2.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2015.12.005"},{"key":"2024060408250451000_2023.08.13.553101v2.15","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0015"},{"key":"2024060408250451000_2023.08.13.553101v2.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.073"},{"key":"2024060408250451000_2023.08.13.553101v2.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23051-9"},{"key":"2024060408250451000_2023.08.13.553101v2.18","doi-asserted-by":"crossref","unstructured":"Cook, P. 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