{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:15:05Z","timestamp":1774476905531,"version":"3.50.1"},"posted":{"date-parts":[[2023,9,6]]},"group-title":"Neurology","reference-count":64,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,9,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec id=\"s21\">\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Disrupted sleep is common in individuals with Alzheimer\u2019s disease (AD) and may be a marker for AD risk. The timing of sleep or chronotype affects sleep-wake activity and is also associated with AD, but little is known about links between sleep and chronotype in older adults. In this study, we tested if different measures of sleep and chronotype are associated among older adults even after adjusting for multiple potentially confounding variables.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec id=\"s22\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Participants (N=243) with a mean age of 74 underwent standardized cognitive assessments, measurement of CSF AD biomarkers, and sleep monitoring via single-channel EEG, actigraphy, and self-reported sleep logs. Chronotype was defined as the midpoint of sleep measured by actigraphy.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec id=\"s23\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Later mid-point of sleep (i.e., late chronotype) was associated with African American race and greater night-to-night variability in the sleep mid-point. After controlling for age, race, sex, cognitive status, AD biomarkers, and sleep disorders, a later mid-point of sleep was associated with longer rapid eye movement (REM) onset latency, decreased REM sleep time, lower sleep efficiency, increased sleep onset latency, and more awakenings at night. Late chronotype was also associated with increased &lt;2 Hz non-REM slow-wave activity.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec id=\"s24\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>\n                    To identify individuals at risk for cognitive impairment before symptoms onset, non-invasive\n                    <jats:italic>in vivo<\/jats:italic>\n                    markers of brain function, such as sleep, are needed to track both future risk of cognitive impairment and response to interventions. Chronotype is a potential modifiable AD risk factor and should also be taken into account when using sleep as a marker for AD risk.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2023.09.04.23294997","type":"posted-content","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:10:23Z","timestamp":1694049023000},"source":"Crossref","is-referenced-by-count":5,"title":["Chronotype is Associated with Sleep Quality in Older Adults"],"prefix":"10.64898","author":[{"given":"Scott C.","family":"Sauers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina D.","family":"Toedebusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam P.","family":"Spira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-825X","authenticated-orcid":false,"given":"Brendan P.","family":"Lucey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023090905350519000_2023.09.04.23294997v1.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"2023090905350519000_2023.09.04.23294997v1.2","unstructured":"Prince M , Wimo A , Guerchet M , Ali G-C , Wu Y-T , Prina M . 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