{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:54:54Z","timestamp":1790816094761,"version":"4.1.0"},"posted":{"date-parts":[[2023,9,13]]},"group-title":"Neuroscience","reference-count":128,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>The lifespan growth of the functional connectome remains unknown. Here, we assemble task-free functional and structural magnetic resonance imaging data from 33,250 individuals aged 32 postmenstrual weeks to 80 years from 132 global sites. We report critical inflection points in the nonlinear growth curves of the global mean and variance of the connectome, peaking in the late fourth and late third decades of life, respectively. After constructing a fine-grained, lifespan-wide suite of system-level brain atlases, we show distinct maturation timelines for functional segregation within different systems. Lifespan growth of regional connectivity is organized along a primary-to-association cortical axis. These connectome-based normative models reveal substantial individual heterogeneities in functional brain networks in patients with autism spectrum disorder, major depressive disorder, and Alzheimer\u2019s disease. These findings elucidate the lifespan evolution of the functional connectome and can serve as a normative reference for quantifying individual variation in development, aging, and neuropsychiatric disorders.<\/jats:p>","DOI":"10.1101\/2023.09.12.557193","type":"posted-content","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T20:30:18Z","timestamp":1694637018000},"source":"Crossref","is-referenced-by-count":32,"title":["Functional connectome through the human life span"],"prefix":"10.64898","author":[{"given":"Lianglong","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengda","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingrui","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaolang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxuan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchao","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pindong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taolin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingliang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaixu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjia","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingna","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-4871","authenticated-orcid":false,"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0377-7424","authenticated-orcid":false,"given":"Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaizhu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9096-9610","authenticated-orcid":false,"given":"Chu-Chung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiwang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Po","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Men","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozheng","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianmei","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanpei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongtao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0081-6048","authenticated-orcid":false,"given":"Peng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Cam-CAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Developing Human Connectome Project","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"DIDA-MDD Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"MCADI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"NSPN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024061301000538000_2023.09.12.557193v3.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0010042"},{"key":"2024061301000538000_2023.09.12.557193v3.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.09.016"},{"key":"2024061301000538000_2023.09.12.557193v3.3","doi-asserted-by":"crossref","unstructured":"Park, H.J. & Friston, K . Structural and functional brain networks: from connections to cognition. Science 342, 1238411 (2013).","DOI":"10.1126\/science.1238411"},{"key":"2024061301000538000_2023.09.12.557193v3.4","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4502"},{"key":"2024061301000538000_2023.09.12.557193v3.5","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"2024061301000538000_2023.09.12.557193v3.6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tics.2016.10.005","article-title":"Human Connectomics across the Life Span","volume":"21","year":"2017","journal-title":"Trends Cogn Sci"},{"key":"2024061301000538000_2023.09.12.557193v3.7","doi-asserted-by":"publisher","DOI":"10.1177\/1073858416635986"},{"key":"2024061301000538000_2023.09.12.557193v3.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.06.003"},{"key":"2024061301000538000_2023.09.12.557193v3.9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neuroimage.2017.01.047","article-title":"The emergence of functional architecture during early brain development","volume":"160","year":"2017","journal-title":"Neuroimage"},{"key":"2024061301000538000_2023.09.12.557193v3.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.050"},{"key":"2024061301000538000_2023.09.12.557193v3.11","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S1474-4422(15)00050-2","article-title":"Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan","volume":"14","year":"2015","journal-title":"The Lancet Neurology"},{"key":"2024061301000538000_2023.09.12.557193v3.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.02.011"},{"key":"2024061301000538000_2023.09.12.557193v3.13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41582-022-00753-3","article-title":"Functional brain networks in the evaluation of patients with neurodegenerative disorders","volume":"19","year":"2023","journal-title":"Nat Rev Neurol"},{"key":"2024061301000538000_2023.09.12.557193v3.14","doi-asserted-by":"crossref","unstructured":"Chai, Y. , et al. Functional connectomics in depression: insights into therapies. Trends Cogn Sci (2023).","DOI":"10.1016\/j.tics.2023.05.006"},{"key":"2024061301000538000_2023.09.12.557193v3.15","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3901"},{"key":"2024061301000538000_2023.09.12.557193v3.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.08.009"},{"key":"2024061301000538000_2023.09.12.557193v3.17","doi-asserted-by":"publisher","DOI":"10.3109\/03014460.2012.694475"},{"key":"2024061301000538000_2023.09.12.557193v3.18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41586-022-04554-y","article-title":"Brain charts for the human lifespan","volume":"604","year":"2022","journal-title":"Nature"},{"key":"2024061301000538000_2023.09.12.557193v3.19","first-page":"e72904","article-title":"Charting brain growth and aging at high spatial precision","volume":"11","year":"2021","journal-title":"eLife"},{"key":"2024061301000538000_2023.09.12.557193v3.20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/psyrad\/kkab022","article-title":"Neuroimaging brain growth charts: A road to mental health","volume":"1","year":"2021","journal-title":"Psychoradiology"},{"key":"2024061301000538000_2023.09.12.557193v3.21","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.14159"},{"key":"2024061301000538000_2023.09.12.557193v3.22","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24669"},{"key":"2024061301000538000_2023.09.12.557193v3.23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911855107"},{"key":"2024061301000538000_2023.09.12.557193v3.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.07.067"},{"key":"2024061301000538000_2023.09.12.557193v3.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2013.11.004"},{"key":"2024061301000538000_2023.09.12.557193v3.26","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-017-1973-1"},{"key":"2024061301000538000_2023.09.12.557193v3.27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuroimage.2017.09.025","article-title":"Trajectories of brain system maturation from childhood to older adulthood: Implications for lifespan cognitive functioning","volume":"163","year":"2017","journal-title":"Neuroimage"},{"key":"2024061301000538000_2023.09.12.557193v3.28","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neuroimage.2018.02.066","article-title":"Evolution of spatial and temporal features of functional brain networks across the lifespan","volume":"173","year":"2018","journal-title":"Neuroimage"},{"key":"2024061301000538000_2023.09.12.557193v3.29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044530"},{"key":"2024061301000538000_2023.09.12.557193v3.30","doi-asserted-by":"crossref","first-page":"e85082","DOI":"10.7554\/eLife.85082","article-title":"Evidence for embracing normative modeling","volume":"12","year":"2023","journal-title":"eLife"},{"key":"2024061301000538000_2023.09.12.557193v3.31","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23403"},{"key":"2024061301000538000_2023.09.12.557193v3.32","doi-asserted-by":"crossref","unstructured":"Luo, A.C. , et al. Functional connectivity development along the sensorimotor-association axis enhances the cortical hierarchy. Nature Communications 15 (2024).","DOI":"10.1038\/s41467-024-47748-w"},{"key":"2024061301000538000_2023.09.12.557193v3.33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055347"},{"key":"2024061301000538000_2023.09.12.557193v3.34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502829112"},{"key":"2024061301000538000_2023.09.12.557193v3.35","doi-asserted-by":"crossref","unstructured":"Sanders, A.F.P. , et al. Age-related differences in resting-state functional connectivity from childhood to adolescence. Cereb Cortex (2023).","DOI":"10.1093\/cercor\/bhad011"},{"key":"2024061301000538000_2023.09.12.557193v3.36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.dcn.2014.08.002","article-title":"Development of the Default Mode and Central Executive Networks across early adolescence: A longitudinal study","volume":"10","year":"2014","journal-title":"Developmental Cognitive Neuroscience"},{"key":"2024061301000538000_2023.09.12.557193v3.37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002328"},{"key":"2024061301000538000_2023.09.12.557193v3.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.07.014"},{"key":"2024061301000538000_2023.09.12.557193v3.39","doi-asserted-by":"crossref","unstructured":"Hull, J.V. , et al. Resting-State Functional Connectivity in Autism Spectrum Disorders: A Review. Front Psychiatry 7, 205 (2016).","DOI":"10.3389\/fpsyt.2016.00205"},{"key":"2024061301000538000_2023.09.12.557193v3.40","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41582-021-00529-1","article-title":"The human connectome in Alzheimer disease - relationship to biomarkers and genetics","volume":"17","year":"2021","journal-title":"Nat Rev Neurol"},{"key":"2024061301000538000_2023.09.12.557193v3.41","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2227"},{"key":"2024061301000538000_2023.09.12.557193v3.42","doi-asserted-by":"crossref","unstructured":"D. Mikis Stasinopoulos , R.A.R. Generalized Additive Models for Location Scale and Shape (GAMLSS) in R. Journal of Statistical Software 23 (2007).","DOI":"10.18637\/jss.v023.i07"},{"key":"2024061301000538000_2023.09.12.557193v3.43","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3171\/2021.2.PEDS201006","article-title":"Normal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid","volume":"28","year":"2021","journal-title":"J Neurosurg Pediatr"},{"key":"2024061301000538000_2023.09.12.557193v3.44","doi-asserted-by":"crossref","first-page":"119178","DOI":"10.1016\/j.neuroimage.2022.119178","article-title":"Growth charts of brain morphometry for preschool children","volume":"255","year":"2022","journal-title":"Neuroimage"},{"key":"2024061301000538000_2023.09.12.557193v3.45","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.scib.2020.07.027","article-title":"Charting brain growth in tandem with brain templates at school age","volume":"65","year":"2020","journal-title":"Science Bulletin"},{"key":"2024061301000538000_2023.09.12.557193v3.46","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2017.07.011"},{"key":"2024061301000538000_2023.09.12.557193v3.47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2007032"},{"key":"2024061301000538000_2023.09.12.557193v3.48","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1093\/cercor\/bhy123","article-title":"Spatial Topography of Individual-Specific Cortical Networks Predicts Human Cognition, Personality, and Emotion","volume":"29","year":"2019","journal-title":"Cereb Cortex"},{"key":"2024061301000538000_2023.09.12.557193v3.49","unstructured":"Cui, Z. , et al. Individual Variation in Functional Topography of Association Networks in Youth. Neuron (2020)."},{"key":"2024061301000538000_2023.09.12.557193v3.50","doi-asserted-by":"crossref","unstructured":"Bijsterbosch, J.D. , et al. The relationship between spatial configuration and functional connectivity of brain regions. Elife 7 (2018).","DOI":"10.7554\/eLife.32992"},{"key":"2024061301000538000_2023.09.12.557193v3.51","doi-asserted-by":"crossref","unstructured":"Molloy, M.F. & Saygin, Z.M . Individual variability in functional organization of the neonatal brain. Neuroimage 253, 119101 (2022).","DOI":"10.1016\/j.neuroimage.2022.119101"},{"key":"2024061301000538000_2023.09.12.557193v3.52","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab118"},{"key":"2024061301000538000_2023.09.12.557193v3.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2014.09.001"},{"key":"2024061301000538000_2023.09.12.557193v3.54","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu088"},{"key":"2024061301000538000_2023.09.12.557193v3.55","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs043"},{"key":"2024061301000538000_2023.09.12.557193v3.56","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1093\/cercor\/bhac202","article-title":"Network-specific selectivity of functional connections in the neonatal brain","volume":"33","year":"2023","journal-title":"Cereb Cortex"},{"key":"2024061301000538000_2023.09.12.557193v3.57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuroimage.2017.01.079","article-title":"Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature","volume":"160","year":"2017","journal-title":"Neuroimage"},{"key":"2024061301000538000_2023.09.12.557193v3.58","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"2024061301000538000_2023.09.12.557193v3.59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068910"},{"key":"2024061301000538000_2023.09.12.557193v3.60","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4164"},{"key":"2024061301000538000_2023.09.12.557193v3.61","first-page":"27","article-title":"Use of an Individual-Level Approach to Identify Cortical Connectivity Biomarkers in Obsessive-Compulsive Disorder","volume":"4","year":"2019","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"2024061301000538000_2023.09.12.557193v3.62","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26303"},{"key":"2024061301000538000_2023.09.12.557193v3.63","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01500-4"},{"key":"2024061301000538000_2023.09.12.557193v3.64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415122111"},{"key":"2024061301000538000_2023.09.12.557193v3.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2017.11.002"},{"key":"2024061301000538000_2023.09.12.557193v3.66","doi-asserted-by":"crossref","unstructured":"Sydnor, V.J. , et al. Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology. Neuron (2021).","DOI":"10.1016\/j.neuron.2021.06.016"},{"key":"2024061301000538000_2023.09.12.557193v3.67","doi-asserted-by":"crossref","unstructured":"Xia, Y. , et al. Development of functional connectome gradients during childhood and adolescence. Science Bulletin (2022).","DOI":"10.1016\/j.scib.2022.01.002"},{"key":"2024061301000538000_2023.09.12.557193v3.68","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1038\/s41467-022-30244-4","article-title":"Dissociable multi-scale patterns of development in personalized brain networks","volume":"13","year":"2022","journal-title":"Nat Commun"},{"key":"2024061301000538000_2023.09.12.557193v3.69","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2018.05.070"},{"key":"2024061301000538000_2023.09.12.557193v3.70","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0111-z"},{"key":"2024061301000538000_2023.09.12.557193v3.71","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1909"},{"key":"2024061301000538000_2023.09.12.557193v3.72","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1089\/brain.2016.0429","article-title":"Sex and Age Effects of Functional Connectivity in Early Adulthood","volume":"6","year":"2016","journal-title":"Brain Connect"},{"key":"2024061301000538000_2023.09.12.557193v3.73","doi-asserted-by":"crossref","first-page":"eabm7825","DOI":"10.1126\/sciadv.abm7825","article-title":"Sexually divergent development of depression-related brain networks during healthy human adolescence","volume":"8","year":"2022","journal-title":"Science Advances"},{"key":"2024061301000538000_2023.09.12.557193v3.74","first-page":"47","article-title":"Different cortical connectivities in human females and males relate to differences in strength and body composition, reward and emotional systems, and memory","volume":"229","year":"2024","journal-title":"Brain Struct Funct"},{"key":"2024061301000538000_2023.09.12.557193v3.75","doi-asserted-by":"crossref","unstructured":"Sun, X. , et al. Mapping Neurophysiological Subtypes of Major Depressive Disorder Using Normative Models of the Functional Connectome. Biol Psychiatry (2023).","DOI":"10.1016\/j.biopsych.2023.05.021"},{"key":"2024061301000538000_2023.09.12.557193v3.76","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1001\/jamapsychiatry.2018.2467","article-title":"Mapping the Heterogeneous Phenotype of Schizophrenia and Bipolar Disorder Using Normative Models","volume":"75","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"2024061301000538000_2023.09.12.557193v3.77","doi-asserted-by":"crossref","first-page":"e85082","DOI":"10.7554\/eLife.85082","article-title":"Evidence for embracing normative modeling","volume":"12","year":"2023","journal-title":"Elife"},{"key":"2024061301000538000_2023.09.12.557193v3.78","doi-asserted-by":"crossref","unstructured":"Segal, A. , et al. Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders. Nat Neurosci (2023).","DOI":"10.1038\/s41593-023-01404-6"},{"key":"2024061301000538000_2023.09.12.557193v3.79","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.12.023"},{"key":"2024061301000538000_2023.09.12.557193v3.80","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1001\/jamapsychiatry.2023.0791","article-title":"Evaluation of Brain-Body Health in Individuals With Common Neuropsychiatric Disorders","volume":"80","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"2024061301000538000_2023.09.12.557193v3.81","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/s41591-023-02296-6","article-title":"Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality","volume":"29","year":"2023","journal-title":"Nat Med"},{"key":"2024061301000538000_2023.09.12.557193v3.82","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/s41596-022-00696-5","article-title":"The normative modeling framework for computational psychiatry","volume":"17","year":"2022","journal-title":"Nat Protoc"},{"key":"2024061301000538000_2023.09.12.557193v3.83","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.tics.2016.10.001","article-title":"Functional Connectivity of the Human Brain in Utero","volume":"20","year":"2016","journal-title":"Trends Cogn Sci"},{"key":"2024061301000538000_2023.09.12.557193v3.84","first-page":"247","article-title":"Learning in Infancy Is Active","volume":"2","year":"2020","journal-title":"Endogenously Motivated, and Depends on the Prefrontal Cortices. Annual Review of Developmental Psychology"},{"key":"2024061301000538000_2023.09.12.557193v3.85","doi-asserted-by":"crossref","unstructured":"Gao, W. Evidence on the emergence of the brain\u2019s default network from 2-week-old to 2-year-old healthy pediatric subjects. PNAS (2009).","DOI":"10.1073\/pnas.0811221106"},{"key":"2024061301000538000_2023.09.12.557193v3.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2014.02.004"},{"key":"2024061301000538000_2023.09.12.557193v3.87","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1038\/s41467-019-10217-w","article-title":"Abeta-induced vulnerability propagates via the brain\u2019s default mode network","volume":"10","year":"2019","journal-title":"Nat Commun"},{"key":"2024061301000538000_2023.09.12.557193v3.88","doi-asserted-by":"crossref","unstructured":"Wales, R.M. & Leung, H.-C.J.B.C . The effects of amyloid and tau on functional network connectivity in older populations. 11, 599\u2013612 (2021).","DOI":"10.1089\/brain.2020.0902"},{"key":"2024061301000538000_2023.09.12.557193v3.89","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41583-018-0067-3","article-title":"Imaging the evolution and pathophysiology of Alzheimer disease","volume":"19","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"2024061301000538000_2023.09.12.557193v3.90","doi-asserted-by":"crossref","first-page":"e960","DOI":"10.1002\/ctm2.960","article-title":"Translational potential of human brain charts","volume":"12","year":"2022","journal-title":"Clin Transl Med"},{"key":"2024061301000538000_2023.09.12.557193v3.91","doi-asserted-by":"crossref","unstructured":"Zhou, Z.X. , Chen, L.Z. , Milham, M.P. , Zuo, X.N. & Lifespan Brain Chart , C. Six cornerstones for translational brain charts. Sci Bull (Beijing) (2023).","DOI":"10.1016\/j.scib.2023.03.047"},{"key":"2024061301000538000_2023.09.12.557193v3.92","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/jamapsychiatry.2020.3794","article-title":"Functional magnetic resonance imaging\u2013guided personalization of transcranial magnetic stimulation treatment for depression","volume":"78","year":"2021","journal-title":"JAMA psychiatry"},{"key":"2024061301000538000_2023.09.12.557193v3.93","unstructured":"Lotter, L.D. , et al. Human cortex development is shaped by molecular and cellular brain systems. bioRxiv (2023)."},{"key":"2024061301000538000_2023.09.12.557193v3.94","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01042-4"},{"key":"2024061301000538000_2023.09.12.557193v3.95","doi-asserted-by":"crossref","unstructured":"Kopal, J. , Uddin, L.Q. & Bzdok, D . The end game: respecting major sources of population diversity. Nat Methods (2023).","DOI":"10.1038\/s41592-023-01812-3"},{"key":"2024061301000538000_2023.09.12.557193v3.96","doi-asserted-by":"crossref","unstructured":"Stenger, V.A. Technical considerations for BOLD fMRI of the orbitofrontal cortex. in The Orbitofrontal Cortex (ed. D. Zald & S. Rauch ) 0 (Oxford University Press, 2006).","DOI":"10.1093\/acprof:oso\/9780198565741.003.0017"},{"key":"2024061301000538000_2023.09.12.557193v3.97","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00073-9"},{"key":"2024061301000538000_2023.09.12.557193v3.98","doi-asserted-by":"crossref","first-page":"e0278776","DOI":"10.1371\/journal.pone.0278776","article-title":"Closing the life-cycle of normative modeling using federated hierarchical Bayesian regression","volume":"17","year":"2022","journal-title":"PLoS One"},{"key":"2024061301000538000_2023.09.12.557193v3.99","doi-asserted-by":"crossref","first-page":"119699","DOI":"10.1016\/j.neuroimage.2022.119699","article-title":"Accommodating site variation in neuroimaging data using normative and hierarchical Bayesian models","volume":"264","year":"2022","journal-title":"Neuroimage"},{"key":"2024061301000538000_2023.09.12.557193v3.100","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2216798120"},{"key":"2024061301000538000_2023.09.12.557193v3.101","doi-asserted-by":"crossref","unstructured":"Elyounssi, S. , et al. Uncovering and mitigating bias in large, automated MRI analyses of brain development. bioRxiv (2023).","DOI":"10.1101\/2023.02.28.530498"},{"key":"2024061301000538000_2023.09.12.557193v3.102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184661."},{"key":"2024061301000538000_2023.09.12.557193v3.103","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.neuroimage.2017.12.059","article-title":"Quantitative assessment of structural image quality","volume":"169","year":"2018","journal-title":"Neuroimage"},{"key":"2024061301000538000_2023.09.12.557193v3.104","doi-asserted-by":"crossref","unstructured":"Wang, L. , et al. Benchmark on Automatic 6-month-old Infant Brain Segmentation Algorithms: The iSeg-2017 Challenge. IEEE Trans Med Imaging (2019).","DOI":"10.1109\/TMI.2019.2901712"},{"key":"2024061301000538000_2023.09.12.557193v3.105","doi-asserted-by":"crossref","unstructured":"Zeng, Z. , et al. 3DlJMASNet: 3D mixedlJscale asymmetric convolutional segmentation network for 6lJmonthlJold infant brain MR images. Human Brain Mapping (2022).","DOI":"10.1101\/2021.05.23.445294"},{"key":"2024061301000538000_2023.09.12.557193v3.106","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.127"},{"key":"2024061301000538000_2023.09.12.557193v3.107","doi-asserted-by":"crossref","unstructured":"Ji, J.L. , et al. QuNex\u2014An integrative platform for reproducible neuroimaging analytics. Frontiers in Neuroinformatics 17 (2023).","DOI":"10.3389\/fninf.2023.1104508"},{"key":"2024061301000538000_2023.09.12.557193v3.108","doi-asserted-by":"crossref","unstructured":"Feczko, E. , et al. Adolescent Brain Cognitive Development (ABCD) Community MRI Collection and Utilities. (2021).","DOI":"10.1101\/2021.07.09.451638"},{"key":"2024061301000538000_2023.09.12.557193v3.109","doi-asserted-by":"publisher","DOI":"10.1101\/125526"},{"key":"2024061301000538000_2023.09.12.557193v3.110","doi-asserted-by":"crossref","unstructured":"Wang, L. , et al. iBEAT V2.0: a multisite-applicable, deep learning-based pipeline for infant cerebral cortical surface reconstruction. Nat Protoc (2023).","DOI":"10.1038\/s41596-023-00806-x"},{"key":"2024061301000538000_2023.09.12.557193v3.111","doi-asserted-by":"crossref","unstructured":"Williams, L.Z.J. , et al. Structural and functional asymmetry of the neonatal cerebral cortex. Nat Hum Behav (2023).","DOI":"10.1038\/s41562-023-01542-8"},{"key":"2024061301000538000_2023.09.12.557193v3.112","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24636"},{"key":"2024061301000538000_2023.09.12.557193v3.113","doi-asserted-by":"crossref","unstructured":"Fitzgibbon, S.P. , et al. The developing Human Connectome Project (dHCP) automated resting-state functional processing framework for newborn infants. Neuroimage 223, 117303 (2020).","DOI":"10.1016\/j.neuroimage.2020.117303"},{"key":"2024061301000538000_2023.09.12.557193v3.114","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.105"},{"key":"2024061301000538000_2023.09.12.557193v3.115","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00339.2011"},{"key":"2024061301000538000_2023.09.12.557193v3.116","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.12.028"},{"key":"2024061301000538000_2023.09.12.557193v3.117","doi-asserted-by":"crossref","unstructured":"Sun, L. , et al. Structural insight into the individual variability architecture of the functional brain connectome. Neuroimage, 119387 (2022).","DOI":"10.1016\/j.neuroimage.2022.119387"},{"key":"2024061301000538000_2023.09.12.557193v3.118","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.006"},{"key":"2024061301000538000_2023.09.12.557193v3.119","first-page":"1914","article-title":"3rd, Hu, X.P. & Mayberg","volume":"33","year":"2012","journal-title":"H.S. A whole brain fMRI atlas generated via spatially constrained spectral clustering. Hum Brain Mapp"},{"key":"2024061301000538000_2023.09.12.557193v3.120","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/10618600.1996.10474708","article-title":"Randomized Quantile Residuals","volume":"5","year":"1996","journal-title":"Journal of Computational and Graphical Statistics"},{"key":"2024061301000538000_2023.09.12.557193v3.121","doi-asserted-by":"crossref","unstructured":"Dinga, R. , et al. Normative modeling of neuroimaging data using generalized additive models of location scale and shape. bioRxiv (2021).","DOI":"10.1101\/2021.06.14.448106"},{"key":"2024061301000538000_2023.09.12.557193v3.122","unstructured":"Flexible Regression and Smoothing Using GAMLSS in R."},{"key":"2024061301000538000_2023.09.12.557193v3.123","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.06.045"},{"key":"2024061301000538000_2023.09.12.557193v3.124","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-&lt;otherinfo&gt;018-0065-y"},{"key":"2024061301000538000_2023.09.12.557193v3.125","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"2024061301000538000_2023.09.12.557193v3.126","doi-asserted-by":"crossref","unstructured":"Charrad, M. , Ghazzali, N. , Boiteau, V. & Niknafs, A.J.J.o.s.s . NbClust: an R package for determining the relevant number of clusters in a data set. 61, 1\u201336 (2014).","DOI":"10.18637\/jss.v061.i06"},{"key":"2024061301000538000_2023.09.12.557193v3.127","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23112"},{"key":"2024061301000538000_2023.09.12.557193v3.128","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.06.001"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2023.09.12.557193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:13:28Z","timestamp":1768454008000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2023.09.12.557193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":128,"URL":"https:\/\/doi.org\/10.1101\/2023.09.12.557193","relation":{},"subject":[],"published":{"date-parts":[[2023,9,13]]},"subtype":"preprint"}}