{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:59:33Z","timestamp":1768507173118,"version":"3.49.0"},"posted":{"date-parts":[[2023,9,13]]},"group-title":"Neuroscience","reference-count":95,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Epigenetic regulation of neuronal transcriptomic landscape is emerging to be a key coordinator of mammalian neural regeneration. Here we investigated roles of two histone 3 lysine 27 (H3K27) demethylases Kdm6a\/b in controlling neuroprotection and axon regeneration. Deleting either Kdm6a or Kdm6b led to enhanced sensory axon regeneration in the PNS, whereas in the CNS only deleting Kdm6a in retinal ganglion cells (RGCs) significantly enhanced optic nerve regeneration. Moreover, both Kdm6a and Kdm6b functioned to regulate RGC survival but with different mechanisms. Mechanistically, Kdm6a regulates RGC regeneration via distinct pathway from that of Pten and co-deleting Kdm6a and Pten resulted in long distance optic nerve regeneration passing the optic chiasm. In addition, RNA-seq profiling revealed that Kdm6a deletion switched the RGC transcriptomics into a developmental-like state and suppressed several known repressors of neural regeneration. Klf4 was identified as a direct downstream target of Kdm6a-H3K27me3 signaling in both sensory neurons and RGCs to regulate axon regeneration. These findings not only revealed different roles of Kdm6a and Kdm6b in regulation of neural regeneration and their underlying mechanisms, but also identified Kdm6a- mediated histone demethylation signaling as a novel epigenetic target for supporting CNS neural regeneration.<\/jats:p>","DOI":"10.1101\/2023.09.12.557354","type":"posted-content","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T11:55:17Z","timestamp":1694865317000},"source":"Crossref","is-referenced-by-count":0,"title":["Roles of Kdm6a and Kdm6b in regulation of mammalian neural regeneration"],"prefix":"10.64898","author":[{"given":"Shu-Guang","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Rui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Yun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Saijilafu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Mei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1525-9969","authenticated-orcid":false,"given":"Feng-Quan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024100622300756000_2023.09.12.557354v2.1","doi-asserted-by":"crossref","unstructured":"Z. He , Y. Jin , Neuron 2016, 90 (3), 437.","DOI":"10.1016\/j.neuron.2016.04.022"},{"key":"2024100622300756000_2023.09.12.557354v2.2","doi-asserted-by":"crossref","unstructured":"C. Qian , F. Q. Zhou , J Mol Cell Biol 2020, 12 (10), 798.","DOI":"10.1093\/jmcb\/mjaa026"},{"key":"2024100622300756000_2023.09.12.557354v2.3","doi-asserted-by":"crossref","unstructured":"S. G. Yang , C. P. Li , X. Q. Peng , Z. Q. Teng , C. M. Liu , F. Q. Zhou , Front Cell Neurosci 2020, 14, 119.","DOI":"10.3389\/fncel.2020.00119"},{"key":"2024100622300756000_2023.09.12.557354v2.4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175737"},{"key":"2024100622300756000_2023.09.12.557354v2.5","doi-asserted-by":"crossref","unstructured":"F. Blandini , E. Bazzini , F. Marino , F. Saporiti , M. T. Armentero , C. Pacchetti , R. Zangaglia , E. Martignoni , S. Lecchini , G. Nappi , M. Cosentino , Clin Neuropharmacol 2009, 32 (3), 133.","DOI":"10.1097\/WNF.0B013E3181761466"},{"key":"2024100622300756000_2023.09.12.557354v2.6","doi-asserted-by":"crossref","unstructured":"P. D. Smith , F. Sun , K. K. Park , B. Cai , C. Wang , K. Kuwako , I. Martinez-Carrasco , L. Connolly , Z. He , Neuron 2009, 64 (5), 617.","DOI":"10.1016\/j.neuron.2009.11.021"},{"key":"2024100622300756000_2023.09.12.557354v2.7","doi-asserted-by":"publisher","DOI":"10.1038\/nature10594"},{"key":"2024100622300756000_2023.09.12.557354v2.8","doi-asserted-by":"crossref","unstructured":"K. J. O\u2019Donovan , K. Ma , H. Guo , C. Wang , F. Sun , S. B. Han , H. Kim , J. K. Wong , J. Charron , H. Zou , Y. J. Son , Z. He , J. Zhong , J Exp Med 2014, 211 (5), 801.","DOI":"10.1084\/jem.20131780"},{"key":"2024100622300756000_2023.09.12.557354v2.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.060"},{"key":"2024100622300756000_2023.09.12.557354v2.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.04.010"},{"key":"2024100622300756000_2023.09.12.557354v2.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.105"},{"key":"2024100622300756000_2023.09.12.557354v2.12","doi-asserted-by":"crossref","unstructured":"Y. Zhang , P. R. Williams , A. Jacobi , C. Wang , A. Goel , A. A. Hirano , N. C. Brecha , D. Kerschensteiner , Z. He , Neuron 2019, 103 (1), 39.","DOI":"10.1016\/j.neuron.2019.04.033"},{"key":"2024100622300756000_2023.09.12.557354v2.13","doi-asserted-by":"crossref","unstructured":"J. Minarovits , F. Banati , K. Szenthe , H. H. Niller , Adv Exp Med Biol 2016, 879, 1.","DOI":"10.1007\/978-3-319-24738-0_1"},{"key":"2024100622300756000_2023.09.12.557354v2.14","doi-asserted-by":"crossref","unstructured":"I. T. Strickland , L. Richards , F. E. Holmes , D. Wynick , J. B. Uney , L. F. Wong , PLoS One 2011, 6 (8), e23423.","DOI":"10.1371\/journal.pone.0023423"},{"key":"2024100622300756000_2023.09.12.557354v2.15","doi-asserted-by":"crossref","unstructured":"J. J. Jiang , C. M. Liu , B. Y. Zhang , X. W. Wang , M. Zhang , Saijilafu, S. R. Zhang, P. Hall, Y. W. Hu, F. Q. Zhou, Cell Death Dis 2015, 6e, e1865.","DOI":"10.1038\/cddis.2015.239"},{"key":"2024100622300756000_2023.09.12.557354v2.16","doi-asserted-by":"publisher","DOI":"10.1101\/gad.209619.112"},{"key":"2024100622300756000_2023.09.12.557354v2.17","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9965-4"},{"issue":"14","key":"2024100622300756000_2023.09.12.557354v2.18","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1002\/1873-3468.12718","volume":"591","year":"2017","journal-title":"FEBS Lett"},{"key":"2024100622300756000_2023.09.12.557354v2.19","doi-asserted-by":"publisher","DOI":"10.1101\/gad.193243.112"},{"key":"2024100622300756000_2023.09.12.557354v2.20","doi-asserted-by":"crossref","unstructured":"Y. L. Weng , R. An , J. Cassin , J. Joseph , R. Mi , C. Wang , C. Zhong , S. G. Jin , G. P. Pfeifer , A. Bellacosa , X. Dong , A. Hoke , Z. He , H. Song , G. L. Ming , Neuron 2017, 94 (2), 337.","DOI":"10.1016\/j.neuron.2017.03.034"},{"key":"2024100622300756000_2023.09.12.557354v2.21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40000"},{"key":"2024100622300756000_2023.09.12.557354v2.22","doi-asserted-by":"crossref","unstructured":"Y. E. Loh , A. Koemeter-Cox , M. J. Finelli , L. Shen , R. H. Friedel , H. Zou , Epigenetics 2017, 12 (2), 77.","DOI":"10.1080\/15592294.2016.1264560"},{"key":"2024100622300756000_2023.09.12.557354v2.23","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr142"},{"key":"2024100622300756000_2023.09.12.557354v2.24","doi-asserted-by":"crossref","unstructured":"Y. Cho , R. Sloutsky , K. M. Naegle , V. Cavalli , Cell 2013, 155 (4), 894.","DOI":"10.1016\/j.cell.2013.10.004"},{"key":"2024100622300756000_2023.09.12.557354v2.25","doi-asserted-by":"crossref","unstructured":"M. J. Finelli , J. K. Wong , H. Zou , J Neurosci 2013, 33 (50), 19664.","DOI":"10.1523\/JNEUROSCI.0589-13.2013"},{"key":"2024100622300756000_2023.09.12.557354v2.26","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4527"},{"issue":"11","key":"2024100622300756000_2023.09.12.557354v2.27","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1038\/s41593-019-0490-4","volume":"22","year":"2019","journal-title":"Nat Neurosci"},{"key":"2024100622300756000_2023.09.12.557354v2.28","unstructured":"X. W. Wang , S. G. Yang , M. W. Hu , R. Y. Wang , C. Zhang , A. R. Kosanam , A. J. Ochuba , J. J. Jiang , X. Luo , Y. Guan , J. Qian , C. M. Liu , F. Q. Zhou , J Clin Invest 2024, 134 (3)."},{"key":"2024100622300756000_2023.09.12.557354v2.29","unstructured":"W. L. Tai , K. S. Cho , E. Kriukov , A. Ashok , X. Wang , A. Monavarfeshani , W. Yan , Y. Li , T. Guan , J. R. Sanes , P. Baranov , D. F. Chen , bioRxiv 2023."},{"key":"2024100622300756000_2023.09.12.557354v2.30","unstructured":"M. Zhang , Y. Zhang , Q. Xu , J. Crawford , C. Qian , G. H. Wang , J. Qian , X. Z. Dong , M. V. Pletnikov , C. M. Liu , F. Q. Zhou, Neurosci Bull 2023."},{"key":"2024100622300756000_2023.09.12.557354v2.31","doi-asserted-by":"publisher","DOI":"10.1038\/nature06192"},{"key":"2024100622300756000_2023.09.12.557354v2.32","doi-asserted-by":"publisher","DOI":"10.1038\/nature06145"},{"key":"2024100622300756000_2023.09.12.557354v2.33","doi-asserted-by":"crossref","unstructured":"K. B. Shpargel , T. Sengoku , S. Yokoyama , T. Magnuson , PLoS Genet 2012, 8 (9), e 1002964.","DOI":"10.1371\/journal.pgen.1002964"},{"key":"2024100622300756000_2023.09.12.557354v2.34","doi-asserted-by":"crossref","unstructured":"S. Hong , Y. W. Cho , L. R. Yu , H. Yu , T. D. Veenstra , K. Ge , Proc Natl Acad Sci U S A 2007, 104 (47), 18439.","DOI":"10.1073\/pnas.0707292104"},{"key":"2024100622300756000_2023.09.12.557354v2.35","doi-asserted-by":"crossref","unstructured":"G. G. Welstead , M. P. Creyghton , S. Bilodeau , A. W. Cheng , S. Markoulaki , R. A. Young , R. Jaenisch , Proc Natl Acad Sci U S A 2012, 109 (32), 13004.","DOI":"10.1073\/pnas.1210787109"},{"key":"2024100622300756000_2023.09.12.557354v2.36","doi-asserted-by":"crossref","unstructured":"X. Yang , B. Xu , B. Mulvey , M. Evans , S. Jordan , Y. D. Wang , V. Pagala , J. Peng , Y. Fan , A. Patel , J. C. Peng , Nat Neurosci 2019, 22 (3), 362.","DOI":"10.1038\/s41593-018-0328-5"},{"key":"2024100622300756000_2023.09.12.557354v2.37","doi-asserted-by":"crossref","unstructured":"Y. Shan , Y. Zhang , Y. Zhao , T. Wang , J. Zhang , J. Yao , N. Ma , Z. Liang , W. Huang , K. Huang , T. Zhang , Z. Su , Q. Chen , Y. Zhu , C. Wu , T. Zhou , W. Sun , Y. Wei , C. Zhang , C. Li , S. Su , B. Liao , M. Zhong , X. Zhong , J. Nie , D. Pei , G. Pan , Nat Commun 2020, 11 (1), 382.","DOI":"10.1038\/s41467-019-14028-x"},{"key":"2024100622300756000_2023.09.12.557354v2.38","doi-asserted-by":"crossref","unstructured":"N. Pediconi , D. Salerno , L. Lupacchini , A. Angrisani , G. Peruzzi , E. De Smaele , M. Levrero , L. Belloni , Cell Death Dis 2019, 10 (7), 518.","DOI":"10.1038\/s41419-019-1755-2"},{"key":"2024100622300756000_2023.09.12.557354v2.39","doi-asserted-by":"crossref","unstructured":"E. Cuyas , S. Verdura , L. Llorach-Pares , S. Fernandez-Arroyo , F. Luciano-Mateo , N. Cabre , J. Stursa , L. Werner , B. Martin-Castillo , B. Viollet , J. Neuzil , J. Joven , A. Nonell-Canals , M. Sanchez-Martinez , J. A. Menendez , Aging Cell 2018, 17 (4), e 12772.","DOI":"10.1111\/acel.12772"},{"key":"2024100622300756000_2023.09.12.557354v2.40","doi-asserted-by":"crossref","unstructured":"C. Jin , J. Li , C. D. Green , X. Yu , X. Tang , D. Han , B. Xian , D. Wang , X. Huang , X. Cao , Z. Yan , L. Hou , J. Liu , N. Shukeir , P. Khaitovich , C. D. Chen , H. Zhang , T. Jenuwein , J. D. Han , Cell Metab 2011, 14 (2), 161.","DOI":"10.1016\/j.cmet.2011.07.001"},{"key":"2024100622300756000_2023.09.12.557354v2.41","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.491"},{"key":"2024100622300756000_2023.09.12.557354v2.42","doi-asserted-by":"publisher","DOI":"10.1101\/gad.510809"},{"key":"2024100622300756000_2023.09.12.557354v2.43","doi-asserted-by":"publisher","DOI":"10.1038\/nature11272"},{"key":"2024100622300756000_2023.09.12.557354v2.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.006"},{"key":"2024100622300756000_2023.09.12.557354v2.45","doi-asserted-by":"crossref","unstructured":"X. Li , Q. Zhang , Q. Shi , Y. Liu , K. Zhao , Q. Shen , Y. Shi , X. Liu , C. Wang , N. Li , Y. Ma , X. Cao , J Autoimmun 2017, 80, 85.","DOI":"10.1016\/j.jaut.2017.02.007"},{"key":"2024100622300756000_2023.09.12.557354v2.46","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-014-1182-x"},{"key":"2024100622300756000_2023.09.12.557354v2.47","doi-asserted-by":"crossref","unstructured":"G. van Haaften , G. L. Dalgliesh , H. Davies , L. Chen , G. Bignell , C. Greenman , S. Edkins , C. Hardy , S. O\u2019Meara , J. Teague , A. Butler , J. Hinton , C. Latimer , J. Andrews , S. Barthorpe , D. Beare , G. Buck , P. J. Campbell , J. Cole , S. Forbes , M. Jia , D. Jones , C. Y. Kok , C. Leroy , M. L. Lin , D. J. McBride , M. Maddison , S. Maquire , K. McLay , A. Menzies , T. Mironenko , L. Mulderrig , L. Mudie , E. Pleasance , R. Shepherd , R. Smith , L. Stebbings , P. Stephens , G. Tang , P. S. Tarpey , R. Turner , K. Turrell , J. Varian , S. West , S. Widaa , P. Wray , V. P. Collins , K. Ichimura , S. Law , J. Wong , S. T. Yuen , S. Y. Leung , G. Tonon , R. A. DePinho , Y. T. Tai , K. C. Anderson , R. J. Kahnoski , A. Massie , S. K. Khoo , B. T. Teh , M. R. Stratton , P. A. Futreal , Nat Genet 2009, 41 (5), 521.","DOI":"10.1038\/ng.349"},{"key":"2024100622300756000_2023.09.12.557354v2.48","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu136"},{"key":"2024100622300756000_2023.09.12.557354v2.49","doi-asserted-by":"crossref","unstructured":"Y. Tang , T. Li , J. Li , J. Yang , H. Liu , X. J. Zhang , W. Le , Cell Death Differ 2014, 21 (3), 369.","DOI":"10.1038\/cdd.2013.159"},{"key":"2024100622300756000_2023.09.12.557354v2.50","doi-asserted-by":"crossref","unstructured":"W. Song , N. Zsindely , A. Farago , J. L. Marsh , L. Bodai , Hum Mol Genet 2018, 27 (4), 649.","DOI":"10.1093\/hmg\/ddx432"},{"key":"2024100622300756000_2023.09.12.557354v2.51","doi-asserted-by":"crossref","unstructured":"W. Wang , H. Cho , J. W. Lee , S. K. Lee , Nat Commun 2022, 13 (1), 958.","DOI":"10.1038\/s41467-022-30449-7"},{"key":"2024100622300756000_2023.09.12.557354v2.52","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw1026"},{"key":"2024100622300756000_2023.09.12.557354v2.53","doi-asserted-by":"crossref","unstructured":"Q. Y. Tang , S. F. Zhang , S. K. Dai , C. Liu , Y. Y. Wang , H. Z. Du , Z. Q. Teng , C. M. Liu , Stem Cell Reports 2020, 15 (2), 439.","DOI":"10.1016\/j.stemcr.2020.06.015"},{"key":"2024100622300756000_2023.09.12.557354v2.54","doi-asserted-by":"crossref","unstructured":"R. Wijayatunge , F. Liu , K. B. Shpargel , N. J. Wayne , U. Chan , J. V. Boua , T. Magnuson , A. E. West , Mol Cell Neurosci 2018, 87, 4.","DOI":"10.1016\/j.mcn.2017.11.005"},{"key":"2024100622300756000_2023.09.12.557354v2.55","doi-asserted-by":"crossref","unstructured":"R. Wijayatunge , L. F. Chen , Y. M. Cha , A. S. Zannas , C. L. Frank , A. E. West , Mol Cell Neurosci 2014, 61, 187.","DOI":"10.1016\/j.mcn.2014.06.008"},{"key":"2024100622300756000_2023.09.12.557354v2.56","doi-asserted-by":"crossref","unstructured":"Saijilafu, E. M. Hur, F. Q. Zhou, Nat Commun 2011, 2, 543.","DOI":"10.1038\/ncomms1568"},{"key":"2024100622300756000_2023.09.12.557354v2.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron"},{"key":"2024100622300756000_2023.09.12.557354v2.58","doi-asserted-by":"crossref","unstructured":"X. W. Wang , S. G. Yang , C. Zhang , M. W. Hu , J. Qian , J. J. Ma , Y. Zhang , B. B. Yang , Y. L. Weng , G. L. Ming , A. R. Kosanam , Saijilafu, F. Q. Zhou, Cell Rep 2020, 31 (3), 107537.","DOI":"10.1016\/j.celrep.2020.107537"},{"key":"2024100622300756000_2023.09.12.557354v2.59","doi-asserted-by":"crossref","unstructured":"L. J. Walport , R. J. Hopkinson , M. Vollmar , S. K. Madden , C. Gileadi , U. Oppermann , C. J. Schofield , C. Johansson , J Biol Chem 2014, 289 (26), 18302.","DOI":"10.1074\/jbc.M114.555052"},{"key":"2024100622300756000_2023.09.12.557354v2.60","doi-asserted-by":"crossref","unstructured":"C. Wang , J. E. Lee , Y. W. Cho , Y. Xiao , Q. Jin , C. Liu , K. Ge , Proc Natl Acad Sci U S A 2012, 109 (38), 15324.","DOI":"10.1073\/pnas.1204166109"},{"key":"2024100622300756000_2023.09.12.557354v2.61","doi-asserted-by":"publisher","DOI":"10.1038\/nature11262"},{"key":"2024100622300756000_2023.09.12.557354v2.62","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161566"},{"key":"2024100622300756000_2023.09.12.557354v2.63","doi-asserted-by":"crossref","unstructured":"S. G. Yang , X. W. Wang , C. Qian , F. Q. Zhou , Prog Neurobiol 2022, 214, 102284.","DOI":"10.1016\/j.pneurobio.2022.102284"},{"key":"2024100622300756000_2023.09.12.557354v2.64","doi-asserted-by":"crossref","unstructured":"C. Wilson , L. E. Giono , V. Rozes-Salvador , A. Fiszbein , A. R. Kornblihtt , A. Caceres , Cell Rep 2020, 31 (6), 107639.","DOI":"10.1016\/j.celrep.2020.107639"},{"key":"2024100622300756000_2023.09.12.557354v2.65","doi-asserted-by":"crossref","unstructured":"A. P. Barnes , B. N. Lilley , Y. A. Pan , L. J. Plummer , A. W. Powell , A. N. Raines , J. R. Sanes , F. Polleux , Cell 2007, 129 (3), 549.","DOI":"10.1016\/j.cell.2007.03.025"},{"key":"2024100622300756000_2023.09.12.557354v2.66","doi-asserted-by":"crossref","unstructured":"D. Romaus-Sanjurjo , J. M. Saikia , H. J. Kim , K. M. Tsai , G. Q. Le , B. Zheng , Cell Death Discov 2022, 8 (1), 390.","DOI":"10.1038\/s41420-022-01186-z"},{"key":"2024100622300756000_2023.09.12.557354v2.67","doi-asserted-by":"crossref","unstructured":"P. Y. Wang , G. K. Seabold , R. J. Wenthold , Mol Cell Neurosci 2008, 39 (1), 83.","DOI":"10.1016\/j.mcn.2008.05.019"},{"key":"2024100622300756000_2023.09.12.557354v2.68","doi-asserted-by":"crossref","unstructured":"S. Qin , Y. Zou , C. L. Zhang , Nat Commun 2013, 4, 2633.","DOI":"10.1038\/ncomms3187"},{"key":"2024100622300756000_2023.09.12.557354v2.69","doi-asserted-by":"crossref","unstructured":"E. R. Bray , B. J. Yungher , K. Levay , M. Ribeiro , G. Dvoryanchikov , A. C. Ayupe , K. Thakor , V. Marks , M. Randolph , M. C. Danzi , T. M. Schmidt , N. Chaudhari , V. P. Lemmon , S. Hattar , K. K. Park , Neuron 2019, 103 (4), 642.","DOI":"10.1016\/j.neuron.2019.05.044"},{"key":"2024100622300756000_2023.09.12.557354v2.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.031"},{"key":"2024100622300756000_2023.09.12.557354v2.71","unstructured":"X. W. Wang , S. G. Yang , M. W. Hu , R. Y. Wang , C. Zhang , A. R. Kosanam , A. J. Ochuba , J. J. Jiang , X. M. Luo , Y. Guan , J. Qian , C. M. Liu , F. Q. Zhou , Journal of Clinical Investigation 2024, 134 (3)."},{"key":"2024100622300756000_2023.09.12.557354v2.72","doi-asserted-by":"crossref","unstructured":"J. H. Xu , X. Z. Qin , H. N. Zhang , Y. X. Ma , S. B. Qi , H. C. Zhang , J. J. Ma , X. Y. Fu , J. L. Xie , Saijilafu, Neural Regen Res 2021, 16 (1), 166.","DOI":"10.4103\/1673-5374.286978"},{"key":"2024100622300756000_2023.09.12.557354v2.73","doi-asserted-by":"crossref","unstructured":"W. Renthal , I. Tochitsky , L. T. Yang , Y. C. Cheng , E. Li , R. Kawaguchi , D. H. Geschwind , C. J. Woolf , Neuron 2020, 108 (1), 128.","DOI":"10.1016\/j.neuron.2020.07.026"},{"key":"2024100622300756000_2023.09.12.557354v2.74","doi-asserted-by":"crossref","unstructured":"T. Burgold, F. Spreafico, F. De Santa, M. G. Totaro, E. Prosperini, G. Natoli, G. Testa, PLoS One 2008, 3 (8), e 3034.","DOI":"10.1371\/journal.pone.0003034"},{"key":"2024100622300756000_2023.09.12.557354v2.75","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600642R"},{"key":"2024100622300756000_2023.09.12.557354v2.76","doi-asserted-by":"crossref","unstructured":"L. Yang , L. S. Song , X. F. Liu , Q. Xia , L. G. Bai , L. Gao , G. Q. Gao , Y. Wang , Z. Y. Wei , C. L. Bai , G. P. Li , Sci Rep 2016, 6, 26711.","DOI":"10.1038\/srep26711"},{"key":"2024100622300756000_2023.09.12.557354v2.77","doi-asserted-by":"crossref","unstructured":"M. Shahhoseini , Z. Taghizadeh , M. Hatami , H. Baharvand , Biochem Cell Biol 2013, 91 (2), 116.","DOI":"10.1139\/bcb-2012-0049"},{"issue":"6606","key":"2024100622300756000_2023.09.12.557354v2.78","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.abm9735","volume":"377","year":"2022","journal-title":"Science"},{"key":"2024100622300756000_2023.09.12.557354v2.79","doi-asserted-by":"crossref","unstructured":"A. R. R. Guillermo , K. Chocian , G. Gavriilidis , J. Vandamme , A. E. Salcini , J. Mellor , A. Woollard , BMC Biol 2021, 19 (1), 59.","DOI":"10.1186\/s12915-021-00984-8"},{"key":"2024100622300756000_2023.09.12.557354v2.80","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2100948"},{"key":"2024100622300756000_2023.09.12.557354v2.81","doi-asserted-by":"publisher","DOI":"10.1038\/nature13605"},{"key":"2024100622300756000_2023.09.12.557354v2.82","doi-asserted-by":"crossref","unstructured":"J. Van der Meulen , V. Sanghvi , K. Mavrakis , K. Durinck , F. Fang , F. Matthijssens , P. Rondou , M. Rosen , T. Pieters , P. Vandenberghe , E. Delabesse , T. Lammens , B. De Moerloose , B. Menten , N. Van Roy , B. Verhasselt , B. Poppe , Y. Benoit , T. Taghon , A. M. Melnick , F. Speleman , H. G. Wendel , P. Van Vlierberghe , Blood 2015, 125 (1), 13.","DOI":"10.1182\/blood-2014-05-577270"},{"key":"2024100622300756000_2023.09.12.557354v2.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.006"},{"key":"2024100622300756000_2023.09.12.557354v2.84","doi-asserted-by":"crossref","unstructured":"S. Sol\u00e1 , J. M. Xavier , D. M. Santos , M. M. Aranha , A. L. Morgado , K. Jepsen , C. M. P. Rodrigues , Plos One 2011, 6 (3).","DOI":"10.1371\/journal.pone.0018421"},{"key":"2024100622300756000_2023.09.12.557354v2.85","doi-asserted-by":"crossref","unstructured":"C. I. Ene , L. Edwards , G. Riddick , M. Baysan , K. Woolard , S. Kotliarova , C. Lai , G. Belova , M. Cam , J. Walling , M. Zhou , H. Stevenson , H. S. Kim , K. Killian , T. Veenstra , R. Bailey , H. Song , W. Zhang , H. A. Fine , Plos One 2012, 7 (12).","DOI":"10.1371\/journal.pone.0051407"},{"key":"2024100622300756000_2023.09.12.557354v2.86","doi-asserted-by":"crossref","unstructured":"H. N. Zhang , J. Wang , J. Huang , T. Y. Shi , X. Ma , X. X. Luo , X. Li , M. K. Li , Experimental Neurology 2018, 308, 132.","DOI":"10.1016\/j.expneurol.2018.07.007"},{"key":"2024100622300756000_2023.09.12.557354v2.87","doi-asserted-by":"publisher","DOI":"10.1038\/nature06192"},{"key":"2024100622300756000_2023.09.12.557354v2.88","doi-asserted-by":"publisher","DOI":"10.1038\/nature13605"},{"key":"2024100622300756000_2023.09.12.557354v2.89","unstructured":"C. Z. Gao , F. Yin , R. Li , Q. Ruan , C. Y. Meng , K. C. Zhao , Q. S. Zhu, Oxid Med Cell Longev 2021, 2021."},{"key":"2024100622300756000_2023.09.12.557354v2.90","doi-asserted-by":"crossref","unstructured":"J. Y. Lee , W. H. Na , H. Y. Choi , K. H. Lee , B. G. Ju , T. Y. Yune , Neurobiology of Disease 2016, 95, 66.","DOI":"10.1016\/j.nbd.2016.07.015"},{"key":"2024100622300756000_2023.09.12.557354v2.91","doi-asserted-by":"crossref","unstructured":"E. J. Davis , L. Broestl , S. Abdulai-Saiku , K. Worden , L. W. Bonham , E. Minones-Moyano , A. J. Moreno , D. Wang , K. Chang , G. Williams , B. I. Garay , I. Lobach , N. Devidze , D. Kim , C. Anderson-Bergman , G. Q. Yu , C. C. White , J. A. Harris , B. L. Miller , D. A. Bennett , A. P. Arnold , P. L. De Jager , J. J. Palop , B. Panning , J. S. Yokoyama , L. Mucke , D. B. Dubal, Sci Transl Med 2020, 12 (558).","DOI":"10.1126\/scitranslmed.aaz5677"},{"key":"2024100622300756000_2023.09.12.557354v2.92","doi-asserted-by":"crossref","unstructured":"H. A. Quigley , A. T. Broman , Br J Ophthalmol 2006, 90 (3), 262.","DOI":"10.1136\/bjo.2005.081224"},{"key":"2024100622300756000_2023.09.12.557354v2.93","doi-asserted-by":"crossref","unstructured":"S. L. Chiu , C. L. Chu , C. H. Muo , C. L. Chen , S. J. Lan , J Glaucoma 2016, 25 (5), e 514.","DOI":"10.1097\/IJG.0000000000000381"},{"key":"2024100622300756000_2023.09.12.557354v2.94","doi-asserted-by":"crossref","unstructured":"X. Luo , Y. Salgueiro , S. R. Beckerman , V. P. Lemmon , P. Tsoulfas , K. K. Park , Exp Neurol 2013, 247, 653.","DOI":"10.1016\/j.expneurol.2013.03.001"},{"key":"2024100622300756000_2023.09.12.557354v2.95","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0612-07.2007"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2023.09.12.557354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:13:06Z","timestamp":1768453986000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2023.09.12.557354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":95,"URL":"https:\/\/doi.org\/10.1101\/2023.09.12.557354","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1002\/advs.202405537","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2023,9,13]]},"subtype":"preprint"}}