{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:38:37Z","timestamp":1768567117911,"version":"3.49.0"},"posted":{"date-parts":[[2023,9,18]]},"group-title":"Neurology","reference-count":43,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate what factors influence naming ability after temporal lobectomy in patients with drug-resistant epilepsy.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>85 participants with drug-resistant epilepsy who underwent temporal lobe (TL) resective surgery were retrospectively identified (49 left TL and 36 right TL). Naming ability was assessed before and &gt;3 months post-surgery using the Boston Naming Test (BNT).<\/jats:p>\n                  <jats:p>Multivariate lesion-symptom mapping was performed to evaluate whether lesion location related to naming deficits. Multiple regression analyses were conducted to examine if other patient characteristics were significantly associated with pre-to post-surgery changes in naming ability.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    Lesion laterality and location were important predictors of post-surgical naming performance. Naming performance significantly improved after right temporal lobectomy (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.015) while a decrement in performance was observed following left temporal lobectomy (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002). Lesion-symptom mapping showed the decline in naming performance was associated with surgical resection of the anterior left middle temporal gyrus (Brodmann area 21,\n                    <jats:italic>r<\/jats:italic>\n                    =0.41,\n                    <jats:italic>p<\/jats:italic>\n                    = &lt;.001). For left hemisphere surgery, later onset of epilepsy was associated with a greater reduction in post-surgical naming performance (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.01).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Significance<\/jats:title>\n                  <jats:p>There is a wide range of variability in outcomes for naming ability after temporal lobectomy, from significant improvements to decrements observed. If future studies support the association of left anterior middle temporal gyrus resection and impaired naming this may help in surgical planning and discussions of prognosis.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2023.09.18.23295718","type":"posted-content","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T01:40:21Z","timestamp":1695087621000},"source":"Crossref","is-referenced-by-count":0,"title":["Anterolateral temporal lobe localization of dysnomia after temporal lobe epilepsy surgery"],"prefix":"10.64898","author":[{"given":"Asmaa","family":"Mhanna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Bruss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa W.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Matthew 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