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In this work, we hypothesized that aging also affects the function of motor neurons in the peripheral sympathetic ganglia. To test this hypothesis, we compared the electrophysiological responses and ion-channel activity of neurons isolated from the superior cervical ganglia of young (12 weeks), middle-aged (64 weeks), and old (115 weeks) mice. These approaches showed that aging does impact the intrinsic properties of sympathetic motor neurons, increasing spontaneous and evoked firing responses. A reduction of M current emerged as a major contributor to age-related hyperexcitability. Thus, it is essential to consider the effect of aging on motor components of the sympathetic reflex as a crucial part of the mechanism involved in sympathetic overactivity.<\/jats:p>","DOI":"10.1101\/2023.09.27.559800","type":"posted-content","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:55:21Z","timestamp":1696020921000},"source":"Crossref","is-referenced-by-count":0,"title":["Sympathetic Motor Neuron Dysfunction is a Missing Link in Age-Associated Sympathetic Overactivity"],"prefix":"10.64898","author":[{"given":"Lizbeth","family":"de la Cruz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Bui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8397-3649","authenticated-orcid":false,"given":"Claudia 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