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However, the molecular machinery within CTLs that transduces the mechanical information of tumor cells remains unclear. We find that CTL\u2019s mechanosensitive ability requires the activity of the actin-organizing protein Wiskott-Aldrich Syndrome Protein (WASP). WASP activation is modulated by the mechanical properties of antigen-presenting contexts across a wide range of target cell stiffnesses and activated WASP then mediates mechanosensitive activation of early TCR signaling markers in the CTL. Our results provide a molecular link between antigen mechanosensing and CTL immune response and suggest that CTL-intrinsic cytoskeletal organizing principles enable the processing of mechanical information from diverse target cells.<\/jats:p>","DOI":"10.1101\/2023.10.02.560434","type":"posted-content","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T17:05:31Z","timestamp":1696439131000},"source":"Crossref","is-referenced-by-count":1,"title":["WASP facilitates tumor mechanosensitivity in T 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