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We predicted that while watching a drug-themed movie, where cues for drugs and other stimuli share a continuous narrative context, fMRI responses in individuals with heroin use disorder (iHUD) will preferentially synchronize during drug scenes. Results revealed such drug-biased synchronization in the orbitofrontal cortex (OFC), ventromedial and ventrolateral prefrontal cortex, and insula. After 15 weeks of inpatient treatment, there was a significant reduction in this drug-biased shared response in the OFC, which correlated with a concomitant reduction in dynamically-measured craving, suggesting synchronized OFC responses to a drug-themed movie as a neural marker of craving and recovery in iHUD.<\/jats:p>","DOI":"10.1101\/2023.11.02.23297937","type":"posted-content","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T05:25:22Z","timestamp":1698989122000},"source":"Crossref","is-referenced-by-count":2,"title":["Naturalistic drug cue reactivity in heroin use disorder: orbitofrontal synchronization as a marker of craving and recovery"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6765-3864","authenticated-orcid":false,"given":"Greg","family":"Kronberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4897-3990","authenticated-orcid":false,"given":"Ahmet O.","family":"Ceceli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2978-9087","authenticated-orcid":false,"given":"Yuefeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-4436","authenticated-orcid":false,"given":"Pierre-Olivier","family":"Gaudreault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah G.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"McClain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1876-8133","authenticated-orcid":false,"given":"Nelly","family":"Alia-Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1680-229X","authenticated-orcid":false,"given":"Rita Z.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024042211551168000_2023.11.02.23297937v2.1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(93)90013-P"},{"key":"2024042211551168000_2023.11.02.23297937v2.2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.10.1642"},{"key":"2024042211551168000_2023.11.02.23297937v2.3","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neuron.2018.03.048","article-title":"Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review","volume":"98","year":"2018","journal-title":"Neuron"},{"key":"2024042211551168000_2023.11.02.23297937v2.4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41596-021-00649-4","article-title":"A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus","volume":"17","year":"2022","journal-title":"Nat. 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