{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:26:29Z","timestamp":1768566389820,"version":"3.49.0"},"posted":{"date-parts":[[2023,11,8]]},"group-title":"Epidemiology","reference-count":55,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,11,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Social stress experienced in childhood is associated with adverse health later in life. Mitochondrial function has been implicated as a mechanism for how stressful life events \u201cget under the skin\u201d to influence physical wellbeing. Using data from the Study of Muscle, Mobility and Aging (n=879, 59% women), linear models examined whether adverse childhood events (i.e., physical abuse) were associated with two measures of skeletal muscle mitochondrial energetics in older adults: (1) maximal adenosine triphosphate production (ATP\n                  <jats:sub>max<\/jats:sub>\n                  ) and (2) maximal state 3 respiration (Max OXPHOS). Forty-five percent of the sample reported experiencing 1+ adverse childhood event. After adjustment, each additional event was associated with -0.07 SD (95% CI= - 0.12, -0.01) lower ATP\n                  <jats:sub>max<\/jats:sub>\n                  . No association was observed with Max OXPHOS. Adverse childhood events are associated with lower ATP production in later life. Findings indicate that mitochondrial function may be a mechanism in understanding how early social stress influences health in later life.\n                <\/jats:p>","DOI":"10.1101\/2023.11.07.23298177","type":"posted-content","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T14:20:20Z","timestamp":1699453220000},"source":"Crossref","is-referenced-by-count":0,"title":["Childhood adverse life events and skeletal muscle mitochondrial function"],"prefix":"10.64898","author":[{"given":"Kate A.","family":"Duchowny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Mau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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A.","family":"Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023111105401243000_2023.11.07.23298177v1.1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.57.10.778"},{"key":"2023111105401243000_2023.11.07.23298177v1.2","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170300134X"},{"key":"2023111105401243000_2023.11.07.23298177v1.3","doi-asserted-by":"publisher","DOI":"10.1353\/dem.2004.0005"},{"key":"2023111105401243000_2023.11.07.23298177v1.4","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201800077"},{"key":"2023111105401243000_2023.11.07.23298177v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ssmph.2020.100587"},{"key":"2023111105401243000_2023.11.07.23298177v1.6","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez J , Marmisolle I , Tarallo D , Quijano C . Mitochondrial Bioenergetics and Dynamics in Secretion Processes. Front Endocrinol. 2020;11. 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