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Natural killer (NK) cells are a heterogenous group of cells that are critical during viral pathogenesis and are known to be dysregulated during severe COVID-19 infection. Their role in atherosclerotic cardiovascular disease has recently been described. However, the contribution of their altered phenotypes to atherogenesis following severe COVID-19 infection is unknown. We demonstrate for the first time that during and after severe COVID-19, circulating proinflammatory monocytes and activated NK cells act synergistically to increase uptake of oxidized low-density lipoprotein (Ox-LDL) into vascular tissue with subsequent foam cell generation leading to atherogenesis despite recovery from acute infection. Our data provide new insights, revealing the roles of monocytes\/macrophages, and NK cells in COVID-19-related atherogenesis.<\/jats:p>","DOI":"10.1101\/2023.11.10.23298322","type":"posted-content","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:45:12Z","timestamp":1699843512000},"source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Role of NK Cells and Monocytes in Promoting Atherogenesis in Severe COVID-19 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