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Nephron formation rate has a clinically meaningful effect on person-to-person variability in nephron endowment\n                  <jats:sup>1\u20135<\/jats:sup>\n                  , while exerting\n                  <jats:italic>in vitro<\/jats:italic>\n                  control could enable sustained waves of nephrogenesis in organoid-derived synthetic kidney tissues\n                  <jats:sup>6,7<\/jats:sup>\n                  . However, how the kidney arrives at an appropriate number and ratio of nephrons to collecting ducts is unclear. Here we show that nephron formation is rhythmic and synchronized with branching of the ureteric bud tree (the future urinary collecting ducts). We correlate human and mouse spatial transcriptomics data with the branching \u2018life-cycle\u2019 to uncover rhythmically alternating signatures of nephron progenitor differentiation and renewal. The nephron progenitor rhythm parallels rhythmic nuclear elongation and other hallmarks of mechanical tension in surrounding stromal cells that we attribute to branching-induced deformation. Stroma-specific knockdown of actomyosin activity leads to a striking loss of synchronization between nephron formation and ureteric bud branching without blocking either. These results suggest that the stroma acts as a mechanically entrained pacemaker for nephron formation. Together, our findings uncover a feedback mechanism for clock-like coordination of organ composition during exponential growth.\n                <\/jats:p>","DOI":"10.1101\/2023.11.21.568157","type":"posted-content","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T23:20:16Z","timestamp":1700608816000},"source":"Crossref","is-referenced-by-count":4,"title":["A mechanical pacemaker sets rhythmic nephron formation in the kidney"],"prefix":"10.64898","author":[{"given":"Samuel H.","family":"Grindel","sequence":"first","affiliation":[{"name":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Bioengineering Graduate Group, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin N.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Bioengineering Graduate Group, 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