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Past SARS-CoV-2 infection resulted in increased chromatin accessibility of type I interferon (IFN-I) related transcription factors in airway-resident macrophages. Mechanistically, establishment of this innate immune memory required viral pattern recognition and canonical IFN-I signaling and augmented secondary antiviral responses. Past SARS-CoV-2 infection ameliorated disease caused by the heterologous respiratory pathogen influenza A virus. Insights into innate immune memory and how it affects subsequent infections with heterologous pathogens to influence disease pathology could facilitate the development of broadly effective therapeutic strategies.<\/jats:p>","DOI":"10.1101\/2023.11.24.568354","type":"posted-content","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T22:00:12Z","timestamp":1701122412000},"source":"Crossref","is-referenced-by-count":1,"title":["Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-5304","authenticated-orcid":false,"given":"Alexander","family":"Lercher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Gyu","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Heinrich","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison W.","family":"Ashbrook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue S.","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrine","family":"Quirk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma J.","family":"DeGrace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Chiriboga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5885-1276","authenticated-orcid":false,"given":"Brad R.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-4838","authenticated-orcid":false,"given":"Steven Z.","family":"Josefowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3087-8079","authenticated-orcid":false,"given":"Charles M.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023112817151815000_2023.11.24.568354v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.012"},{"key":"2023112817151815000_2023.11.24.568354v1.2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41586-022-04919-3","article-title":"Inflammatory memory and tissue adaptation in sickness and in health","volume":"607","year":"2022","journal-title":"Nature"},{"key":"2023112817151815000_2023.11.24.568354v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/nature05836"},{"key":"2023112817151815000_2023.11.24.568354v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0285-6"},{"key":"2023112817151815000_2023.11.24.568354v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/nature24271"},{"key":"2023112817151815000_2023.11.24.568354v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.12.031"},{"key":"2023112817151815000_2023.11.24.568354v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.01.017"},{"key":"2023112817151815000_2023.11.24.568354v1.8","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.cell.2018.09.042","article-title":"Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity","volume":"175","year":"2018","journal-title":"Cell"},{"key":"2023112817151815000_2023.11.24.568354v1.9","doi-asserted-by":"publisher","DOI":"10.1159\/000355628"},{"key":"2023112817151815000_2023.11.24.568354v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.05.014"},{"key":"2023112817151815000_2023.11.24.568354v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108387"},{"key":"2023112817151815000_2023.11.24.568354v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00181-6"},{"key":"2023112817151815000_2023.11.24.568354v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"2023112817151815000_2023.11.24.568354v1.14","first-page":"162","article-title":"SARS-CoV-2 variant biology: immune escape, transmission and fitness","volume":"21","year":"2023","journal-title":"Nat. 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