{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:19:35Z","timestamp":1768565975116,"version":"3.49.0"},"posted":{"date-parts":[[2023,12,3]]},"group-title":"Nutrition","reference-count":84,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter the host immune system to promote inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microbial dysbiosis, including gestational diabetes mellitus, preeclampsia, preterm birth, and mood disorders. However, the effects of high inflammatory diets on the gut microbiota during pregnancy have yet to be fully explored.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To use a systems-based approach to characterize associations among dietary inflammatory potential, a measure of diet quality, and the gut microbiome during pregnancy.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Forty-nine pregnant persons were recruited prior to 16 weeks of gestation. Participants completed a food frequency questionnaire (FFQ) and provided fecal samples. Dietary inflammatory potential was assessed using the Dietary Inflammatory Index (DII) from FFQ data. Fecal samples were analyzed using 16S rRNA amplicon sequencing. Differential taxon abundance with respect to DII score were identified, and microbial metabolic potential was predicted using PICRUSt2.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    Inflammatory diets were associated with decreased vitamin and mineral intake and dysbiotic gut microbiota structure and predicted metabolism. Gut microbial compositional differences revealed a decrease in short chain fatty acid producers such as\n                    <jats:italic>Faecalibacterium,<\/jats:italic>\n                    and an increase in predicted vitamin B12 synthesis, methylglyoxal detoxification, galactose metabolism and multi drug efflux systems in pregnant individuals with increased DII scores.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Dietary inflammatory potential was associated with a reduction in the consumption of vitamins &amp; minerals and predicted gut microbiota metabolic dysregulation.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2023.12.02.23299325","type":"posted-content","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T02:25:13Z","timestamp":1701656713000},"source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory dietary potential is associated with vitamin depletion and gut microbial dysbiosis in early pregnancy"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-5537","authenticated-orcid":false,"given":"Suzanne A.","family":"Alvernaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7732-608X","authenticated-orcid":false,"given":"Elizabeth S.","family":"Wenzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Unnathi","family":"Nagelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lacey B.","family":"Pezley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bazil","family":"LaBomascus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-7001","authenticated-orcid":false,"given":"Jack A.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-3430","authenticated-orcid":false,"given":"Pauline M.","family":"Maki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-2961","authenticated-orcid":false,"given":"Lisa","family":"Tussing-Humphreys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-4248","authenticated-orcid":false,"given":"Beatriz Pe\u00f1alver","family":"Bernab\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024011813151356000_2023.12.02.23299325v2.1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1295s"},{"key":"2024011813151356000_2023.12.02.23299325v2.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.03.006"},{"key":"2024011813151356000_2023.12.02.23299325v2.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1560-z"},{"issue":"4","key":"2024011813151356000_2023.12.02.23299325v2.4","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1093\/advances\/nmaa156","article-title":"Associations between maternal dietary patterns and perinatal outcomes: a systematic review and meta-analysis of cohort studies","volume":"12","year":"2021","journal-title":"Advances in nutrition"},{"key":"2024011813151356000_2023.12.02.23299325v2.5","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MR0615-272RR"},{"key":"2024011813151356000_2023.12.02.23299325v2.6","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuv053"},{"key":"2024011813151356000_2023.12.02.23299325v2.7","doi-asserted-by":"crossref","first-page":"100477","DOI":"10.1016\/j.ssmph.2019.100477","article-title":"Income inequality and racial disparities in pregnancy-related mortality in the US","volume":"9","year":"2019","journal-title":"SSM-population health"},{"issue":"2","key":"2024011813151356000_2023.12.02.23299325v2.8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1089\/jwh.2020.8882","article-title":"Social and structural determinants of health inequities in maternal health","volume":"30","year":"2021","journal-title":"Journal of women\u2019s health"},{"key":"2024011813151356000_2023.12.02.23299325v2.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneb.2013.04.268"},{"key":"2024011813151356000_2023.12.02.23299325v2.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-017-3026-5"},{"key":"2024011813151356000_2023.12.02.23299325v2.11","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.008"},{"key":"2024011813151356000_2023.12.02.23299325v2.12","doi-asserted-by":"publisher","DOI":"10.1038\/nature12820"},{"key":"2024011813151356000_2023.12.02.23299325v2.13","doi-asserted-by":"publisher","DOI":"10.1038\/nature06244"},{"key":"2024011813151356000_2023.12.02.23299325v2.14","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314786"},{"key":"2024011813151356000_2023.12.02.23299325v2.15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.042"},{"issue":"10","key":"2024011813151356000_2023.12.02.23299325v2.16","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.12998\/wjcc.v10.i10.2976","article-title":"Gut microbiota in gastrointestinal diseases during pregnancy","volume":"10","year":"2022","journal-title":"World Journal of Clinical Cases"},{"key":"2024011813151356000_2023.12.02.23299325v2.17","first-page":"397","volume-title":"Seminars in immunopathology","volume":"42","year":"2020"},{"key":"2024011813151356000_2023.12.02.23299325v2.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00836.x"},{"key":"2024011813151356000_2023.12.02.23299325v2.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.07.008"},{"issue":"01","key":"2024011813151356000_2023.12.02.23299325v2.20","doi-asserted-by":"crossref","first-page":"024","DOI":"10.1055\/s-0037-1604412","article-title":"Maternal gut microbiome biodiversity in pregnancy","volume":"35","year":"2018","journal-title":"American journal of perinatology"},{"issue":"9","key":"2024011813151356000_2023.12.02.23299325v2.21","doi-asserted-by":"crossref","first-page":"796","DOI":"10.3390\/metabo12090796","article-title":"Gut microbiota across normal gestation and gestational diabetes mellitus: A cohort analysis","volume":"12","year":"2022","journal-title":"Metabolites"},{"key":"2024011813151356000_2023.12.02.23299325v2.22","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179721"},{"issue":"2","key":"2024011813151356000_2023.12.02.23299325v2.23","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.immuni.2023.01.015","article-title":"Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation","volume":"56","year":"2023","journal-title":"Immunity"},{"key":"2024011813151356000_2023.12.02.23299325v2.24","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1086056"},{"key":"2024011813151356000_2023.12.02.23299325v2.25","doi-asserted-by":"publisher","DOI":"10.3390\/nu11020330"},{"key":"2024011813151356000_2023.12.02.23299325v2.26","doi-asserted-by":"crossref","first-page":"549678","DOI":"10.3389\/fcimb.2021.549678","article-title":"Gut Microbiota Signatures in Gestational Anemia","volume":"11","year":"2021","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"issue":"1","key":"2024011813151356000_2023.12.02.23299325v2.27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41398-022-02276-3","article-title":"Interactions between perceived stress and microbial-host immune components: two demographically and geographically distinct pregnancy cohorts","volume":"13","year":"2023","journal-title":"Translational Psychiatry"},{"key":"2024011813151356000_2023.12.02.23299325v2.28","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980013002115"},{"issue":"2","key":"2024011813151356000_2023.12.02.23299325v2.29","first-page":"185","article-title":"Perspective: The Dietary Inflammatory Index (DII)\u2014Lessons Learned, Improvements Made, and Future Directions, Advances in Nutrition","volume":"10","year":"2019","journal-title":"Volume"},{"issue":"1","key":"2024011813151356000_2023.12.02.23299325v2.30","doi-asserted-by":"crossref","first-page":"e13349","DOI":"10.1111\/obr.13349","article-title":"The dietary inflammatory index, obesity, type 2 diabetes, and cardiovascular risk factors and diseases","volume":"23","year":"2022","journal-title":"Obesity Reviews"},{"key":"2024011813151356000_2023.12.02.23299325v2.31","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.225581"},{"key":"2024011813151356000_2023.12.02.23299325v2.32","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2017.1347241"},{"key":"2024011813151356000_2023.12.02.23299325v2.33","doi-asserted-by":"publisher","DOI":"10.3390\/nu14112284"},{"key":"2024011813151356000_2023.12.02.23299325v2.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.05.003"},{"key":"2024011813151356000_2023.12.02.23299325v2.35","doi-asserted-by":"crossref","first-page":"112352","DOI":"10.1016\/j.biopha.2021.112352","article-title":"Dual role of microbiota-derived short-chain fatty acids on host and pathogen","volume":"145","year":"2022","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"1","key":"2024011813151356000_2023.12.02.23299325v2.36","doi-asserted-by":"crossref","first-page":"R26","DOI":"10.1152\/ajpregu.00020.2020","article-title":"Influences of environmental factors during preeclampsia. American Journal of Physiology-Regulatory","volume":"319","year":"2020","journal-title":"Integrative and Comparative Physiology"},{"key":"2024011813151356000_2023.12.02.23299325v2.37","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1017\/gmb.2021.2","article-title":"The associations of butyrate-producing bacteria of the gut microbiome with diet quality and muscle health","volume":"2","year":"2021","journal-title":"Gut Microbiome"},{"key":"2024011813151356000_2023.12.02.23299325v2.38","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2021-300262"},{"issue":"4","key":"2024011813151356000_2023.12.02.23299325v2.39","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jand.2013.11.017","article-title":"Evaluation of web-based, self-administered, graphical food frequency questionnaire","volume":"114","year":"2014","journal-title":"Journal of the Academy of Nutrition and Dietetics"},{"key":"2024011813151356000_2023.12.02.23299325v2.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(02)90050-7"},{"key":"2024011813151356000_2023.12.02.23299325v2.41","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"2024011813151356000_2023.12.02.23299325v2.42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061217"},{"issue":"D1","key":"2024011813151356000_2023.12.02.23299325v2.43","first-page":"D590","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","year":"2013","journal-title":"Opens external link in new windowNucl. Acids Res"},{"key":"2024011813151356000_2023.12.02.23299325v2.44","doi-asserted-by":"publisher","DOI":"10.1101\/221499"},{"key":"2024011813151356000_2023.12.02.23299325v2.45","unstructured":"Jeffrey T. Leek , W. Evan Johnson , Hilary S. Parker , Elana J. Fertig , Andrew E. Jaffe , Yuqing Zhang , John D. Storey and Leonardo Collado Torres (2021). sva: Surrogate Variable Analysis. R package version 3.42.0."},{"key":"2024011813151356000_2023.12.02.23299325v2.46","doi-asserted-by":"crossref","unstructured":"Weiss, S. J. , Xu, Z. , Amir, A. , Peddada, S. , Bittinger, K. , Gonzalez, A. , \u2026 & Knight, R. (2015). Effects of library size variance, sparsity, and compositionality on the analysis of microbiome data (No. e1408). PeerJ PrePrints.","DOI":"10.7287\/peerj.preprints.1157v1"},{"issue":"6","key":"2024011813151356000_2023.12.02.23299325v2.47","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/ismej.2013.10","article-title":"Robust estimation of microbial diversity in theory and in practice","volume":"7","year":"2013","journal-title":"The ISME journal"},{"key":"2024011813151356000_2023.12.02.23299325v2.48","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1709.09027"},{"issue":"1","key":"2024011813151356000_2023.12.02.23299325v2.49","first-page":"2354","article-title":"Wilcoxon rank sum test","volume":"3","year":"2013","journal-title":"Encyclopedia of systems biology"},{"key":"2024011813151356000_2023.12.02.23299325v2.50","doi-asserted-by":"publisher","DOI":"10.2307\/1942268"},{"key":"2024011813151356000_2023.12.02.23299325v2.51","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.12.8228-8235.2005"},{"issue":"1","key":"2024011813151356000_2023.12.02.23299325v2.52","first-page":"32","article-title":"A new method for non-parametric multivariate analysis of variance","volume":"26","year":"2001","journal-title":"Austral ecology"},{"key":"2024011813151356000_2023.12.02.23299325v2.53","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2658"},{"key":"2024011813151356000_2023.12.02.23299325v2.54","doi-asserted-by":"publisher","DOI":"10.2307\/2346101"},{"key":"2024011813151356000_2023.12.02.23299325v2.55","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0548-6"},{"key":"2024011813151356000_2023.12.02.23299325v2.56","unstructured":"56. Meijun Chen and Guangchuang Yu (2021). MicrobiomeProfiler: An R\/shiny package for microbiome functional enrichment analysis. R package version 1.0.0. https:\/\/github.com\/YuLab-SMU\/MicrobiomeProfiler\/"},{"issue":"1","key":"2024011813151356000_2023.12.02.23299325v2.57","doi-asserted-by":"crossref","first-page":"e2034549","DOI":"10.1001\/jamanetworkopen.2020.34549","article-title":"Insurance coverage and perinatal health care use among low-income women in the US, 2015-2017","volume":"4","year":"2021","journal-title":"JAMA Network Open"},{"key":"2024011813151356000_2023.12.02.23299325v2.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.06.010"},{"key":"2024011813151356000_2023.12.02.23299325v2.59","doi-asserted-by":"crossref","first-page":"102309","DOI":"10.1016\/j.mib.2023.102309","article-title":"The maternal gut microbiome during pregnancy and its role in maternal and infant health","volume":"74","year":"2023","journal-title":"Current Opinion in Microbiology"},{"issue":"6","key":"2024011813151356000_2023.12.02.23299325v2.60","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/ANC.0000000000000218","article-title":"The maternal microbiome and pregnancy outcomes that impact infant health: a review","volume":"15","year":"2015","journal-title":"Advances in neonatal care: official journal of the National Association of Neonatal Nurses"},{"issue":"2","key":"2024011813151356000_2023.12.02.23299325v2.61","first-page":"e00893","article-title":"Distinct Diet-Microbiota-Metabolism Interactions in Overweight and Obese Pregnant Women: a Metagenomics Approach","volume":"10","year":"2022","journal-title":"Microbiology Spectrum"},{"issue":"2","key":"2024011813151356000_2023.12.02.23299325v2.62","doi-asserted-by":"crossref","first-page":"E276","DOI":"10.1152\/ajpendo.00265.2019","article-title":"Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet","volume":"318","year":"2020","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"issue":"3","key":"2024011813151356000_2023.12.02.23299325v2.63","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3390\/nu15030689","article-title":"Relationship between Diet Quality and Maternal Stool Microbiota in the MUMS Australian Pregnancy Cohort","volume":"15","year":"2023","journal-title":"Nutrients"},{"key":"2024011813151356000_2023.12.02.23299325v2.64","doi-asserted-by":"crossref","unstructured":"O\u2019Connor, H. , Li, S. , Hodge, A. , Callaway, L. , David Mclntyre, H. , Barrett, H. , \u2026 & Nitert, M. D. (2023). Gut microbiome composition is similar between pregnant women with excess body fat with healthy and less healthy dietary intake patterns. Journal of Human Nutrition and Dietetics.","DOI":"10.1111\/jhn.13123"},{"key":"2024011813151356000_2023.12.02.23299325v2.65","first-page":"10","article-title":"Small, but smelly: the importance of Solobacterium moorei in halitosis and other human infections","volume":"6","year":"2020","journal-title":"Heliyon"},{"key":"2024011813151356000_2023.12.02.23299325v2.66","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu966"},{"issue":"1","key":"2024011813151356000_2023.12.02.23299325v2.67","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12866-021-02207-0","article-title":"Association of gestational diabetes mellitus with changes in gut microbiota composition at the species level","volume":"21","year":"2021","journal-title":"BMC microbiology"},{"issue":"4","key":"2024011813151356000_2023.12.02.23299325v2.68","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.3390\/nu13041244","article-title":"Short-chain fatty acids, maternal microbiota and metabolism in pregnancy","volume":"13","year":"2021","journal-title":"Nutrients"},{"key":"2024011813151356000_2023.12.02.23299325v2.69","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-001-0902-7"},{"issue":"9","key":"2024011813151356000_2023.12.02.23299325v2.70","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3390\/nu8090460","article-title":"Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects","volume":"8","year":"2016","journal-title":"Nutrients"},{"issue":"4","key":"2024011813151356000_2023.12.02.23299325v2.71","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/ejh.13571","article-title":"Review of Vitamin B12 deficiency in pregnancy: a diagnosis not to miss as veganism and vegetarianism become more prevalent","volume":"106","year":"2021","journal-title":"European Journal of Haematology"},{"issue":"2","key":"2024011813151356000_2023.12.02.23299325v2.72","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3390\/nu12020479","article-title":"Methylglyoxal, glycated albumin, PAF, and TNF-\u03b1: possible inflammatory and metabolic biomarkers for management of gestational diabetes","volume":"12","year":"2020","journal-title":"Nutrients"},{"issue":"5","key":"2024011813151356000_2023.12.02.23299325v2.73","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1017\/S204017442100074X","article-title":"Early postnatal exposure of rat pups to methylglyoxal induces oxidative stress, inflammation and dysmetabolism at adulthood","volume":"13","year":"2022","journal-title":"Journal of Developmental Origins of Health and Disease"},{"issue":"4","key":"2024011813151356000_2023.12.02.23299325v2.74","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0306-3623(95)02054-3","article-title":"Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification-a role in pathogenesis and antiproliferative chemotherapy","volume":"27","year":"1996","journal-title":"General Pharmacology: The Vascular System"},{"key":"2024011813151356000_2023.12.02.23299325v2.75","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3390\/antiox9100939","article-title":"The glyoxalase system\u2014new insights into an ancient metabolism","volume":"9","year":"2020","journal-title":"Antioxidants (Basel"},{"issue":"8","key":"2024011813151356000_2023.12.02.23299325v2.76","doi-asserted-by":"crossref","first-page":"e1009819","DOI":"10.1371\/journal.ppat.1009819","article-title":"Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes","volume":"17","year":"2021","journal-title":"PLoS pathogens"},{"issue":"2","key":"2024011813151356000_2023.12.02.23299325v2.77","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/15376516.2020.1838019","article-title":"Methylglyoxal disturbs DNA repair and glyoxalase I system in Saccharomyces cerevisiae","volume":"31","year":"2021","journal-title":"Toxicology Mechanisms and Methods"},{"issue":"1","key":"2024011813151356000_2023.12.02.23299325v2.78","doi-asserted-by":"crossref","first-page":"12216","DOI":"10.1038\/s41598-018-30735-9","article-title":"Changes in the gut microbiota composition during pregnancy in patients with gestational diabetes mellitus (GDM)","volume":"8","year":"2018","journal-title":"Scientific reports"},{"issue":"11","key":"2024011813151356000_2023.12.02.23299325v2.79","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1210\/jc.2015-2862","article-title":"Maternal early pregnancy serum metabolites and risk of gestational diabetes mellitus","volume":"100","year":"2015","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"2024011813151356000_2023.12.02.23299325v2.80","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3389\/fnins.2019.01004","article-title":"Brain senescence caused by elevated levels of reactive metabolite methylglyoxal on D-galactose-induced aging mice","volume":"13","year":"2019","journal-title":"Frontiers in Neuroscience"},{"key":"2024011813151356000_2023.12.02.23299325v2.81","first-page":"41","article-title":"The bacteriology of Gardnerella vaginalis","volume":"86","year":"1984","journal-title":"Scandinavian journal of urology and nephrology. Supplementum"},{"key":"2024011813151356000_2023.12.02.23299325v2.82","doi-asserted-by":"crossref","first-page":"737288","DOI":"10.3389\/fmicb.2021.737288","article-title":"Function and inhibitory mechanisms of multidrug efflux pumps","volume":"12","year":"2021","journal-title":"Frontiers in Microbiology"},{"issue":"2","key":"2024011813151356000_2023.12.02.23299325v2.83","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/JPN.0000000000000400","article-title":"Obesity and socioeconomic disparities: rethinking causes and perinatal care","volume":"33","year":"2019","journal-title":"The Journal of perinatal & neonatal nursing"},{"issue":"3","key":"2024011813151356000_2023.12.02.23299325v2.84","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1017\/S1368980000000409","article-title":"The choice of a diet quality indicator to evaluate the nutritional health of populations","volume":"3","year":"2000","journal-title":"Public health nutrition"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2023.12.02.23299325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:45:57Z","timestamp":1768506357000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2023.12.02.23299325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,3]]},"references-count":84,"URL":"https:\/\/doi.org\/10.1101\/2023.12.02.23299325","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.3390\/nu16070935","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2023,12,3]]},"subtype":"preprint"}}