{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:30:32Z","timestamp":1768566632967,"version":"3.49.0"},"posted":{"date-parts":[[2023,12,22]]},"group-title":"Epidemiology","reference-count":39,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In observational studies, the association between alcohol consumption and dementia is mixed.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed two-sample Mendelian randomization (MR) using summary statistics from genome-wide association studies of weekly alcohol consumption and late-onset Alzheimer\u2019s disease and one-sample MR in the Health and Retirement Study (HRS), wave 2012. Inverse variance weighted two-stage regression provided odds ratios of association between alcohol exposure and dementia or cognitively impaired, non-dementia relative to cognitively normal.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Alcohol consumption was not associated with late-onset Alzheimer\u2019s disease using two-sample MR (OR=1.15, 95% confidence interval (CI):[0.78, 1.72]). In HRS, doubling weekly alcohol consumption was not associated with dementia (African ancestries, n=1,322, OR=1.00, 95% CI [0.45, 2.25]; European ancestries, n=7,160, OR=1.37, 95% CI [0.53, 3.51]) or cognitively impaired, non-dementia (African ancestries, n=1,322, OR=1.17, 95% CI [0.69, 1.98]; European ancestries, n=7,160, OR=0.75, 95% CI [0.47, 1.22]).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Alcohol consumption was not associated with cognitively impaired, non-dementia or dementia status.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2023.12.22.23300298","type":"posted-content","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T23:45:15Z","timestamp":1703288715000},"source":"Crossref","is-referenced-by-count":0,"title":["Relationship between alcohol consumption and dementia with Mendelian randomization approaches among older adults in the United States"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1836-0341","authenticated-orcid":false,"given":"Kyle A.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhou","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Zawistowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9605-6337","authenticated-orcid":false,"given":"Kelly M.","family":"Bakulski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-8158","authenticated-orcid":false,"given":"Erin B.","family":"Ware","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2023122619450609000_2023.12.22.23300298v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-2667(21)00249-8"},{"key":"2023122619450609000_2023.12.22.23300298v1.2","unstructured":"Section 2 PE Tables \u2013 Results from the 2021 National Survey on Drug Use and Health: Detailed Tables, SAMHSA, CBHSQ. https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/reports\/rpt39441\/NSDUHDetailedTabs2021\/NSDUHDetailedTabs2021\/NSDUHDetTabsSect2pe2021.htm#tab2.25a. Accessed 9 Aug 2023"},{"key":"2023122619450609000_2023.12.22.23300298v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"2023122619450609000_2023.12.22.23300298v1.4","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0225-3"},{"key":"2023122619450609000_2023.12.22.23300298v1.5","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afn095"},{"key":"2023122619450609000_2023.12.22.23300298v1.6","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181a2fd07"},{"key":"2023122619450609000_2023.12.22.23300298v1.7","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2012.742488"},{"key":"2023122619450609000_2023.12.22.23300298v1.8","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0453-0"},{"key":"2023122619450609000_2023.12.22.23300298v1.9","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01605-0"},{"key":"2023122619450609000_2023.12.22.23300298v1.10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k601"},{"key":"2023122619450609000_2023.12.22.23300298v1.11","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr462"},{"key":"2023122619450609000_2023.12.22.23300298v1.12","doi-asserted-by":"publisher","DOI":"10.3390\/nu14173596"},{"key":"2023122619450609000_2023.12.22.23300298v1.13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000255"},{"key":"2023122619450609000_2023.12.22.23300298v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.09.086"},{"key":"2023122619450609000_2023.12.22.23300298v1.15","doi-asserted-by":"publisher","DOI":"10.1002\/ANA.25918"},{"key":"2023122619450609000_2023.12.22.23300298v1.16","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0307-5"},{"key":"2023122619450609000_2023.12.22.23300298v1.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0358-2"},{"key":"2023122619450609000_2023.12.22.23300298v1.18","doi-asserted-by":"crossref","unstructured":"Elsworth B , Lyon M , Alexander T , et al (2020) The MRC IEU OpenGWAS data infrastructur","DOI":"10.1101\/2020.08.10.244293"},{"key":"2023122619450609000_2023.12.22.23300298v1.19","doi-asserted-by":"publisher","DOI":"10.2307\/146277"},{"key":"2023122619450609000_2023.12.22.23300298v1.20","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"2023122619450609000_2023.12.22.23300298v1.21","unstructured":"(2021) Health and Retirement Study - Quality Control Report for Genotypic Data - Phase 4"},{"key":"2023122619450609000_2023.12.22.23300298v1.22","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0353-1"},{"key":"2023122619450609000_2023.12.22.23300298v1.23","unstructured":"Ware, E. , Gard, A. , Schmitz, L. , & Faul, J . (2020). HRS Polygenic Scores \u2013 Release 4. Survey Research Center, Institute for Social Research, University of Michigan."},{"key":"2023122619450609000_2023.12.22.23300298v1.24","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu067"},{"key":"2023122619450609000_2023.12.22.23300298v1.25","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-016-0804-x"},{"key":"2023122619450609000_2023.12.22.23300298v1.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.08.025"},{"key":"2023122619450609000_2023.12.22.23300298v1.27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007081"},{"key":"2023122619450609000_2023.12.22.23300298v1.28","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408"},{"key":"2023122619450609000_2023.12.22.23300298v1.29","doi-asserted-by":"publisher","DOI":"10.1038\/nature09270"},{"key":"2023122619450609000_2023.12.22.23300298v1.30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120758"},{"key":"2023122619450609000_2023.12.22.23300298v1.31","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr036"},{"key":"2023122619450609000_2023.12.22.23300298v1.32","doi-asserted-by":"publisher","DOI":"10.1515\/em-2018-0024"},{"key":"2023122619450609000_2023.12.22.23300298v1.33","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080"},{"key":"2023122619450609000_2023.12.22.23300298v1.34","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15555.3"},{"key":"2023122619450609000_2023.12.22.23300298v1.35","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.22295"},{"key":"2023122619450609000_2023.12.22.23300298v1.36","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy258"},{"key":"2023122619450609000_2023.12.22.23300298v1.37","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.78"},{"key":"2023122619450609000_2023.12.22.23300298v1.38","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg070"},{"key":"2023122619450609000_2023.12.22.23300298v1.39","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy204"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2023.12.22.23300298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:47:17Z","timestamp":1768506437000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2023.12.22.23300298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1101\/2023.12.22.23300298","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1002\/dad2.12598","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2023,12,22]]},"subtype":"preprint"}}