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Supraphysiological apocrine secretion induced during mouse development by maternal administration of a serotonergic 5HT2C receptor agonist dysregulates offspring cerebral cortical development, alters the fate of CSF-contacting neural progenitors, and ultimately changes adult social behaviors. Critically, exposure to maternal illness or to the psychedelic drug LSD during pregnancy also overactivates the ChP, inducing excessive secretion. Collectively, our findings demonstrate a new mechanism by which maternal exposure to diverse stressors disrupts\n                  <jats:italic>in utero<\/jats:italic>\n                  brain development.\n                <\/jats:p>","DOI":"10.1101\/2024.01.08.574486","type":"posted-content","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T12:21:57Z","timestamp":1704802917000},"source":"Crossref","is-referenced-by-count":7,"title":["A choroid plexus apocrine secretion mechanism shapes CSF proteome and embryonic brain development"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4562-500X","authenticated-orcid":false,"given":"Ya\u2019el","family":"Courtney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua P.","family":"Head","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1432-1484","authenticated-orcid":false,"given":"Elizabeth D.","family":"Yimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4597-2201","authenticated-orcid":false,"given":"Neil","family":"Dani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6030-1206","authenticated-orcid":false,"given":"Frederick B.","family":"Shipley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-8179","authenticated-orcid":false,"given":"Towia A.","family":"Libermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-2967","authenticated-orcid":false,"given":"Maria K.","family":"Lehtinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024011906450628000_2024.01.08.574486v2.1","doi-asserted-by":"publisher","DOI":"10.1113\/JP275376"},{"key":"2024011906450628000_2024.01.08.574486v2.2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2013"},{"key":"2024011906450628000_2024.01.08.574486v2.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3921"},{"key":"2024011906450628000_2024.01.08.574486v2.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04722-0"},{"key":"2024011906450628000_2024.01.08.574486v2.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.06.013"},{"key":"2024011906450628000_2024.01.08.574486v2.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.01.023"},{"key":"2024011906450628000_2024.01.08.574486v2.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.11.015"},{"key":"2024011906450628000_2024.01.08.574486v2.8","doi-asserted-by":"crossref","first-page":"e113116","DOI":"10.1371\/journal.pone.0113116","article-title":"Cerebrospinal fluid extracellular vesicles undergo age dependent declines and contain known and novel non-coding RNAs","volume":"9","year":"2014","journal-title":"PloS One"},{"key":"2024011906450628000_2024.01.08.574486v2.9","doi-asserted-by":"crossref","first-page":"e1800257","DOI":"10.1002\/pmic.201800257","article-title":"UFLC-Derived CSF Extracellular Vesicle Origin and Proteome","volume":"18","year":"2018","journal-title":"Proteomics"},{"key":"2024011906450628000_2024.01.08.574486v2.10","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606271"},{"key":"2024011906450628000_2024.01.08.574486v2.11","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3123"},{"key":"2024011906450628000_2024.01.08.574486v2.12","first-page":"S29","article-title":"Calcium dependencies of regulated exocytosis in different endocrine cells","volume":"60","year":"2011","journal-title":"Physiol. 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