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By focusing on\n                  <jats:italic>Parabacteroides distasonis<\/jats:italic>\n                  (presumed modern succinate-producing commensal probiotic), recovered from intestinal microfistulous tracts (cavernous fistulous micropathologies CavFT proposed as intermediate between \u2018mucosal fissures\u2019 and \u2018fistulas\u2019) in two patients that required surgery to remove CD-damaged ilea, we demonstrate that such isolates exert pathogenic\/pathobiont roles in mouse models of CD. Our isolates are clonally-related; potentially emerging as transmissible in the community and mice; proinflammatory and adapted to the ileum of germ-free mice prone to CD-like ileitis (SAMP1\/YitFc) but not healthy mice (C57BL\/6J), and cytotoxic\/ATP-depleting to HoxB8-immortalized bone marrow derived myeloid cells from SAMP1\/YitFc mice when concurrently exposed to succinate and extracts from CavFT-derived\n                  <jats:italic>E. coli<\/jats:italic>\n                  , but not to cells from healthy mice. With unique genomic features supporting recent genetic exchange with\n                  <jats:italic>Bacteroides fragilis<\/jats:italic>\n                  -BGF539, evidence of international presence in primarily human metagenome databases, these CavFT\n                  <jats:italic>Pdis<\/jats:italic>\n                  isolates could represent to a new opportunistic\n                  <jats:italic>Parabacteroides<\/jats:italic>\n                  species, or subspecies (\u2018\n                  <jats:italic>cavitamuralis\u2019<\/jats:italic>\n                  ) adapted to microfistulous niches in CD.\n                <\/jats:p>","DOI":"10.1101\/2024.01.09.574896","type":"posted-content","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T23:35:26Z","timestamp":1704929726000},"source":"Crossref","is-referenced-by-count":5,"title":["Clonal\n                  <i>Parabacteroides<\/i>\n                  from Gut Microfistulous Tracts as Transmissible Cytotoxic 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