{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:10:12Z","timestamp":1784013012001,"version":"3.55.0"},"posted":{"date-parts":[[2024,1,28]]},"group-title":"Neuroscience","reference-count":35,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Insoluble pathogenic proteins accumulate along blood vessels in conditions of cerebral amyloid angiopathy (CAA), exerting a toxic effect on vascular cells and impacting cerebral homeostasis. In this work we provide new evidence from three-dimensional human brain histology that tau protein, the main component of neurofibrillary tangles, can similarly accumulate along brain vascular segments. We quantitatively assessed n=6 Alzheimer\u2019s disease (AD), and n=6 normal aging control brains and saw that tau-positive blood vessel segments were present in all AD cases. Tau-positive vessels are enriched for tau at levels higher than the surrounding tissue and appear to affect arterioles across cortical layers (I-V). Further, vessels isolated from these AD tissues were enriched for N-terminal tau and tau phosphorylated at T181 and T217. Importantly, tau-positive vessels are associated with local areas of increased tau neurofibrillary tangles. This suggests that accumulation of tau around blood vessels may reflect a local clearance failure. In sum, these data indicate tau, like amyloid beta, accumulates along blood vessels and may exert a significant influence on vasculature in the setting of AD.<\/jats:p>","DOI":"10.1101\/2024.01.27.577088","type":"posted-content","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T22:05:14Z","timestamp":1706479514000},"source":"Crossref","is-referenced-by-count":4,"title":["Brain Vasculature Accumulates Tau and Is Spatially Related to Tau Tangle Pathology in Alzheimer\u2019s Disease"],"prefix":"10.64898","author":[{"given":"Zachary","family":"Hoglund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Ruiz-Uribe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"del Sastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Woost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7959-9401","authenticated-orcid":false,"given":"Bradley T.","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-4482","authenticated-orcid":false,"given":"Theodore","family":"Zwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9640-0575","authenticated-orcid":false,"given":"Rachel E.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024013106050519000_2024.01.27.577088v1.1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.631"},{"key":"2024013106050519000_2024.01.27.577088v1.2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540250089017"},{"key":"2024013106050519000_2024.01.27.577088v1.3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-06-01799.1987"},{"key":"2024013106050519000_2024.01.27.577088v1.4","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.103"},{"key":"2024013106050519000_2024.01.27.577088v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.119"},{"key":"2024013106050519000_2024.01.27.577088v1.6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa179"},{"key":"2024013106050519000_2024.01.27.577088v1.7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3020-14.2014"},{"key":"2024013106050519000_2024.01.27.577088v1.8","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748&lt;\/otherinfo&gt;"},{"key":"2024013106050519000_2024.01.27.577088v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.10.033"},{"key":"2024013106050519000_2024.01.27.577088v1.10","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01014-4"},{"key":"2024013106050519000_2024.01.27.577088v1.11","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.84112"},{"key":"2024013106050519000_2024.01.27.577088v1.12","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad130"},{"key":"2024013106050519000_2024.01.27.577088v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0582-9"},{"key":"2024013106050519000_2024.01.27.577088v1.14","unstructured":"D\u2019Errico J. arclength. 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