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In this study, behavioral and neurophysiologic changes to proactive and reactive control during progressive cognitive-motor demands were compared across older and younger adults to explore the basis for age-differences in cognitive-motor interference (CMI). 19 younger (19 - 29 years old, mean age = 22.84 +\/- 2.75 years, 6 male, 13 female) and 18 older (60 - 77 years old, mean age = 67.89 +\/- 4.60 years, 9 male, 9 female) healthy adults completed cued task-switching while alternating between sitting and walking on a treadmill. Gait kinematics, task performance measures, and brain activity were recorded using electroencephalography (EEG) based Mobile Brain\/Body Imaging (MoBI). Response accuracy on easier trial types improved in younger, but not older adults when they walked while performing the cognitive task. As difficulty increased, walking provoked accuracy costs in older, but not younger adults. Both groups registered faster responses and reduced gait variability during dual-task walking. Older adults exhibited lower amplitude modulations of proactive and reactive neural activity as cognitive-motor demands systematically increased, which may reflect reduced flexibility for progressive preparatory and reactive adjustments over behavioral control.<\/jats:p>","DOI":"10.1101\/2024.01.27.577090","type":"posted-content","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T22:10:16Z","timestamp":1706479816000},"source":"Crossref","is-referenced-by-count":5,"title":["Reduced Proactive and Reactive Cognitive Flexibility in Older Adults Underlies Performance Costs During Dual-Task Walking: A Mobile Brain\/Body Imaging (MoBI) Study"],"prefix":"10.64898","author":[{"given":"David P.","family":"Richardson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4300-3098","authenticated-orcid":false,"given":"John J.","family":"Foxe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8570-6325","authenticated-orcid":false,"given":"Edward G.","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024013103001075000_2024.01.27.577090v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.08.008"},{"key":"2024013103001075000_2024.01.27.577090v1.2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly123"},{"key":"2024013103001075000_2024.01.27.577090v1.3","first-page":"421","article-title":"Shifting Intentional Set - Exploring the Dynamic Control of Tasks","volume":"15","year":"1994","journal-title":"Attention and Performance Xv"},{"key":"2024013103001075000_2024.01.27.577090v1.4","doi-asserted-by":"publisher","DOI":"10.1037\/1076-898X.8.1.6"},{"key":"2024013103001075000_2024.01.27.577090v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2012.02.014"},{"key":"2024013103001075000_2024.01.27.577090v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.12.010"},{"key":"2024013103001075000_2024.01.27.577090v1.7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808187106"},{"key":"2024013103001075000_2024.01.27.577090v1.8","doi-asserted-by":"publisher","DOI":"10.1007\/s00426-015-0686-5"},{"key":"2024013103001075000_2024.01.27.577090v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.05.014"},{"key":"2024013103001075000_2024.01.27.577090v1.10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131556"},{"key":"2024013103001075000_2024.01.27.577090v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.022"},{"key":"2024013103001075000_2024.01.27.577090v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.12.028"},{"key":"2024013103001075000_2024.01.27.577090v1.13","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-008-1338-4"},{"key":"2024013103001075000_2024.01.27.577090v1.14","doi-asserted-by":"crossref","unstructured":"De Sanctis, P. , Butler, J. 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