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We combine optogenetic activation and pharmacology using the cerebellum as a testbed to generate a curated ground-truth library of electrophysiological properties for Purkinje cells, molecular layer interneurons, Golgi cells, and mossy fibers. We train a semi-supervised deep-learning classifier that predicts cell types with greater than 95% accuracy based on waveform, discharge statistics, and layer of the recorded neuron. The classifier\u2019s predictions agree with expert classification on recordings using different probes, in different laboratories, from functionally distinct cerebellar regions, and across animal species. Our classifier extends the power of modern dynamical systems analyses by revealing the unique contributions of simultaneously-recorded cell types during behavior.<\/jats:p>","DOI":"10.1101\/2024.01.30.577845","type":"posted-content","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T08:10:11Z","timestamp":1706688611000},"source":"Crossref","is-referenced-by-count":7,"title":["A deep-learning strategy to identify cell types across species from high-density extracellular recordings"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8907-6612","authenticated-orcid":false,"given":"Maxime","family":"Beau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-0658","authenticated-orcid":false,"given":"David J.","family":"Herzfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-3871","authenticated-orcid":false,"given":"Francisco","family":"Naveros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4071-6084","authenticated-orcid":false,"given":"Marie E.","family":"Hemelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-4370","authenticated-orcid":false,"given":"Federico","family":"D\u2019Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9474-4040","authenticated-orcid":false,"given":"Marlies","family":"Oostland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6253-1064","authenticated-orcid":false,"given":"Alvaro","family":"S\u00e1nchez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Yoon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9949-5463","authenticated-orcid":false,"given":"Michael","family":"Maibach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4237-1996","authenticated-orcid":false,"given":"Stephen","family":"Kyranakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1546-8840","authenticated-orcid":false,"given":"Hannah N.","family":"Stabb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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