{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:35:50Z","timestamp":1786995350164,"version":"build-2736575974"},"posted":{"date-parts":[[2024,1,30]]},"group-title":"Neuroscience","reference-count":84,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["R01NS115716"],"award-info":[{"award-number":["R01NS115716"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["F99NS139545"],"award-info":[{"award-number":["F99NS139545"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]},{"award":["Ben Barres Award"],"award-info":[{"award-number":["Ben Barres Award"]}],"id":[{"id":"https:\/\/ror.org\/02qenvm24","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01MH112766"],"award-info":[{"award-number":["R01MH112766"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]},{"name":"airc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Summary<\/jats:title>\n                <jats:p>\n                  Current models of learning and memory have focused on cell-autonomous regulation of synaptic strength; however, intercellular signaling between cells in the brain is important for normal cognition. The immediate early gene\n                  <jats:italic>Arc<\/jats:italic>\n                  is a repurposed retrotransposon critical for long-term forms of synaptic plasticity and memory. Arc protein forms virus-like capsids released in extracellular vesicles (EVs) that mediate intercellular signaling of unknown function. Here, we find that long-term potentiation stimuli induce the biogenesis of Arc EVs by recruiting the I-BAR protein IRSp53, which facilitates Arc capsid assembly, trafficking, and release from actin-rich filopodial structures in dendrites. Arc EVs transfer Arc protein and mRNA to neighboring dendrites, where translation of transferred\n                  <jats:italic>Arc<\/jats:italic>\n                  mRNA induces a loss of surface AMPA-type glutamate receptors. These results show that Arc EVs mediate an intercellular form of synaptic plasticity that may be critical for memory consolidation and reveals a new neuronal EV biogenesis pathway.\n                <\/jats:p>","DOI":"10.1101\/2024.01.30.578027","type":"posted-content","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T23:25:16Z","timestamp":1706657116000},"source":"Crossref","is-referenced-by-count":6,"title":["Arc mediates intercellular synaptic plasticity via IRSp53-dependent extracellular vesicle biogenesis"],"prefix":"10.64898","author":[{"given":"Kaelan","family":"Sullivan","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Spencer Fox Eccles School of Medicine, University of Utah."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Ravens","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Spencer Fox Eccles School of Medicine, University of 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