{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:09:48Z","timestamp":1789103388884,"version":"build-2803163510"},"posted":{"date-parts":[[2024,2,1]]},"group-title":"Neuroscience","reference-count":106,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>Early life adversity (ELA) can result in increased risk for developing affective disorders, such as anxiety or depression, later in life, with women showing increased risk. Interactions between an individual\u2019s genes and their environment play key roles in producing, as well as mitigating, later life neuropathology. Our current understanding of the underlying epigenomic drivers of ELA associated anxiety and depression are limited, and this stems in part from the complexity of underlying biochemical processes associated with how early experiences shapes later life behavior. Epigenetic alterations, or experience-driven modifications to DNA, can be leveraged to understand the interplay between genes and the environment. The present study characterized DNA methylation patterning, assessed via evaluation of 5-methylcytosine (5-mC), following ELA in a Sprague Dawley rat model of ELA induced by early caregiver deprivation. This study utilized maternal separation to investigate sex- and age-specific outcomes of ELA on epigenetic patterning in parvalbumin (PV)-containing interneurons in the prefrontal cortex (PFC), a subpopulation of inhibitory neurons which are associated with ELA and affective dysfunction. While global analysis of 5-mC methylation and CpG site specific pyrosequencing of the PV promoter, Pvalb, showed no obvious effects of ELA, when analyses were restricted to assessing 5-mC intensity in colocalized PV cells, there were significant sex and age dependent effects. We found that ELA leads sex-specific changes in PV cell counts, and that cell counts can be predicted by 5-mC intensity, with males and females showing distinct patterns of methylation and PV outcomes. ELA also produced sex-specific effects in corticosterone reactivity, with juvenile females showing a blunted stress hormone response compared to controls. Overall, ELA led to a sex-specific developmental shift in PV profile, which is comparable to profiles that are seen at a later developmental timepoint, and this shift may be mediated in part by epigenomic alterations driven by altered DNA methylation.<\/jats:p>","DOI":"10.1101\/2024.01.31.578313","type":"posted-content","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T09:20:19Z","timestamp":1706779219000},"source":"Crossref","is-referenced-by-count":3,"title":["Early life adversity drives sex-dependent changes in 5-mC DNA methylation of parvalbumin cells in the prefrontal cortex in rats"],"prefix":"10.64898","author":[{"given":"Emma S.","family":"Noel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanevith A.","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4879-0203","authenticated-orcid":false,"given":"Jennifer A.","family":"Honeycutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024020507000533000_2024.01.31.578313v1.1","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1997.2318"},{"key":"2024020507000533000_2024.01.31.578313v1.2","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.150205"},{"key":"2024020507000533000_2024.01.31.578313v1.3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.psyneuen.2018.01.020","article-title":"Glucocorticoid receptor gene methylation moderates the association of childhood trauma and cortisol stress reactivity","volume":"90","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"2024020507000533000_2024.01.31.578313v1.4","doi-asserted-by":"crossref","unstructured":"Alshamrani, A.A. , Alshehri, S. , Alqarni, S.S. , Ahmad, S.F. , Alghibiwi, H. , Al-Harbi, N.O. , Alqarni, S.A. , Al-Ayadhi, L.Y. , Attia, S.M. , Alfardan, A.S. , Bakheet, S.A. , Nadeem, A . 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